Leading clinicians and clinical researchers discuss in practical detail the newest treatments used in rheumatic diseases, emphasizing-without neglecting current standard treatments-those experimental therapies now undergoing clinical trials and poised for early introduction into the rheumatology armamentarium. The diseases and therapeutic regimes examined here range from rheumatoid arthritis and its treatment by gene therapy, to osteoarthritis and systemic autoimune diseases. Each chapter is organized so that the busy clinician can quickly obtain all the information needed optimal patient treatment. This includes an analysis of the pathogenic mechanisms that explain the molecular basis of the newer therapeutics, reviews of animal data and the results of clinical trials, and recommendations concerning use, side effects, and precautions.
I. Rheumatoid Arthritis Larry W. Moreland, Section Editor New Treatment Opportunities for Rheumatoid Arthritis Larry W. Moreland Genetic Influences on Treatment Response in Rheumatoid Arthritis S. Louis Bridges, Jr. and Robert P. Kimberly Nonsteroidal Anti-Inflammatory Drugs in the Treatment of Rheumatoid Arthritis John S. Sundy Additional Considerations on the Use of Nonsteroidal Anti-Inflammatory Drugs M. Elaine Husni and Lee S. Simon Glucocorticoid Therapy in Rheumatoid Arthritis Kenneth G. Saag and John R. Kirwan Anti-Tumor Necrosis Factor Agents Alan K. Matsumoto and Joan M. Bathon Interleukin-1 Receptor Antagonist Treatment in Rheumatoid Arthritis Barry Bresnihan Leflunomide: An Immunomodulatory Drug for the Treatment of Rheumatoid Arthritis Paul Emery, David L. Scott, and Vibeke Strand Matrix Metalloproteinase Inhibitors as Therapies for Rheumatoid Arthritis Sean J. Wollaston and Kenneth C. Kalunian Combination Disease-Modifying Anti-Rheumatic Drug (DMARD) Therapy James R. O'Dell Experimental Therapeutics for Rheumatoid Arthritis Mark C. Genovese and William H. Robinson II. Osteoarthritis Jean-Pierre Pelletier and Johanne Martel-Pelletier, Section Editors Slow-Acting Drugs for the Treatment of Osteoarthritis Jean-Yves Reginster and Roy D. Altman Intra-Articular Therapy in Ostheoarthritis Boulos Haraoui and Jean-Pierre Raynauld Promoting Articular Cartilage Repair Joseph A. Buckwalter and James A. Martin Using Molecular Markers to Monitor Osteoarthritis Ivan G. Otterness and Mary J. Saltarelli New Therapeutic Targets for Osteoarthritis: The Rewards of Research Jean-Pierre Pelletier, Johanne Martel-Pelletier, and Pamela Manning Recent Developments in the Therapy of Osteoarthritis Jean-Pierre Pelletier and Johanne Martel-Pelletier III. Systemic Autoimmune Diseases Gary M. Kammer and George C. Tsokos, Section Editors Treatment of Systemic Lupus Erythematosus Peter H. Schur and Gary M. Kammer Treatment of the Antiphospholipid Syndrome Joan T. Merrill Treatment of Systemic Lupus Erythematosus by Blocking T-Cell Costimulation David I. Daikh and David Wofsy Current Management of Systemic Sclerosis Clarence W. Legerton III and Richard M. Silver Sjögren's Syndrome Robert W. Hoffman and Eric L. Greidinger Mixed Connective Tissue Disease Robert W. Hoffman and Eric L. Greidinger Vasculitis Dimitrios Vassilopoulos and Leonard H. Calabrese Treatment of Juvenile Rheumatoid Arthritis Laura J. Mirkinson and Ildy M. Katona Treatment of Inflammatory Myopathies William R. Gilliland Psoriatic Arthritis Dimitrios T. Boumpas and Gabor G. Illei Complement Inhibitors in Rheumatic Diseases Sherry D. Fleming and George C. Tsokos Hematopoietic Stem Cell Transplantation of Autoimmune Disease Richard K. Burt and Ann E. Traynor IV. Gene Therapy in Rheumatic Diseases Steffen Gay, Section Editor Vectors for Gene Delivery Sandro Rusconi and Maurizio Ceppi Gene Targeting of Cytokines and the Mitogen-Activated Protein Kinase Pathways in Human Rheumatoid Synovium Using the Severe Combined Immunodeficiency Mouse Model Jörg Schedel, Thomas Pap, Ulf Müller-Ladner, Renate E. Gray, and Steffen Gay Retroviral Transduction of Antigen-Specific CD4+ T Cells for Local Delivery of Regulatory Molecules Gina L. Costa and C. Garrison Fathman Gene Transfer to Lymphocytes Targeting Cartilagineous Collagen Type II Alexander E. Annenkov and Yuti Chernajovsky Gene Therapy in Murine Arthritis:
The last decade has witnessed enormous progress in our understanding of the molecular and cellular processes that lead to rheumatic diseases and has seen the development and introduction of many novel biologics and drugs. In Modern Therapeutics in Rheumatic Diseases, leading clinicians and clinical researchers discuss in practical detail the newest treatments used in rheumatic diseases, emphasizing-without neglecting currently standard treatments-those experimental therapies now undergoing clinical trials and poised for early introduction into the rheumatology armamentarium. The diseases and therapeutic regimes examined here range from osteoarthritis and systemic autoimmune diseases to rheumatoid arthritis and its treatment by gene therapy. Each chapter is organized so that the busy clinician can quickly obtain all the information needed for optimal patient treatment. This information includes an analysis of the pathogenic mechanisms that explain the molecular basis of the newer therapeutics; reviews of animal data and the results of clinical trials; and recommendations concerning use, side effects, and precautions.
Authoritative and state-of-the-art, Modern Therapeutics in Rheumatic Diseases outlines the rapidly growing body of knowledge emerging from today's cutting-edge research, and shows how these therapeutic breakthroughs are now becoming practical standards of care for the active rheumatologist.
"It is indeed most helpful to those practicing Rheumatology. The author is a credible authority in the subject matter of the book...This book covers an exhaustive list of therapeutic topics. From familiar- such as Non Steroidal Drugs to unusual such as Apoptosis Regulation have been discussed in detail. Subjects such as Gene Therapy are especially well covered. The unique aspect of this book has to be its ability to discuss the latest knowledge in depth without losing sight of its primary objective; examining its clinical applicability...this book will prove to be of incomparable value; especially to practicing rheumatologists. It lays forth clearly what can be offered to the patient and why it may be of benefit when faced with the bewildering choices of therapeutic options available today. There are really no other books quite like it." -Doody's Health Sciences Book Review Journal
"This book could not have been published at a better time from the rheumatology trainee's point of view. It is written in a coherent and concise manner, which serves as an excellent source for all aspects of therapeutics in the rheumatic diseases. Furthermore, the frequent use of diagrams and graphs allowed emphasis of key points. This publication links the basic science of rheumatic diseases to a comprehensive text of therapeutic mechanisms and efficacy." -The Journal of Rheumatology
I. Rheumatoid ArthritisLarry W. Moreland, Section EditorNew Treatment Opportunities for Rheumatoid ArthritisLarry W. MorelandGenetic Influences on Treatment Response in Rheumatoid ArthritisS. Louis Bridges, Jr. and Robert P. KimberlyNonsteroidal Anti-Inflammatory Drugs in the Treatment of Rheumatoid ArthritisJohn S. SundyAdditional Considerations on the Use of Nonsteroidal Anti-Inflammatory DrugsM. Elaine Husni and Lee S. SimonGlucocorticoid Therapy in Rheumatoid ArthritisKenneth G. Saag and John R. KirwanAnti-Tumor Necrosis Factor AgentsAlan K. Matsumoto and Joan M. BathonInterleukin-1 Receptor Antagonist Treatment in Rheumatoid ArthritisBarry BresnihanLeflunomide: An Immunomodulatory Drug for the Treatment of Rheumatoid ArthritisPaul Emery, David L. Scott, and Vibeke StrandMatrix Metalloproteinase Inhibitors as Therapies for Rheumatoid ArthritisSean J. Wollaston and Kenneth C. KalunianCombination Disease-Modifying Anti-Rheumatic Drug (DMARD) TherapyJames R. O'DellExperimental Therapeutics for Rheumatoid ArthritisMark C. Genovese and William H. RobinsonII. OsteoarthritisJean-Pierre Pelletier and Johanne Martel-Pelletier, Section EditorsSlow-Acting Drugs for the Treatment of OsteoarthritisJean-Yves Reginster and Roy D. AltmanIntra-Articular Therapy in OstheoarthritisBoulos Haraoui and Jean-Pierre RaynauldPromoting Articular Cartilage RepairJoseph A. Buckwalter and James A. MartinUsing Molecular Markers to Monitor OsteoarthritisIvan G. Otterness and Mary J. SaltarelliNew Therapeutic Targets for Osteoarthritis: The Rewards of ResearchJean-Pierre Pelletier, Johanne Martel-Pelletier, and Pamela ManningRecent Developments in the Therapy of OsteoarthritisJean-Pierre Pelletier and Johanne Martel-PelletierIII. Systemic Autoimmune DiseasesGary M. Kammer and George C. Tsokos, Section EditorsTreatment of Systemic Lupus ErythematosusPeter H. Schur and Gary M. KammerTreatment of the Antiphospholipid SyndromeJoan T. MerrillTreatment of Systemic Lupus Erythematosus by Blocking T-Cell CostimulationDavid I. Daikh and David WofsyCurrent Management of Systemic SclerosisClarence W. Legerton III and Richard M. SilverSjögren's SyndromeRobert W. Hoffman and Eric L. GreidingerMixed Connective Tissue DiseaseRobert W. Hoffman and Eric L. GreidingerVasculitisDimitrios Vassilopoulos and Leonard H. CalabreseTreatment of Juvenile Rheumatoid ArthritisLaura J. Mirkinson and Ildy M. KatonaTreatment of Inflammatory MyopathiesWilliam R. GillilandPsoriatic ArthritisDimitrios T. Boumpas and Gabor G. IlleiComplement Inhibitors in Rheumatic DiseasesSherry D. Fleming and George C. TsokosHematopoietic Stem Cell Transplantation of Autoimmune DiseaseRichard K. Burt and Ann E. TraynorIV. Gene Therapy in Rheumatic DiseasesSteffen Gay, Section EditorVectors for Gene DeliverySandro Rusconi and Maurizio CeppiGene Targeting of Cytokines and the Mitogen-Activated Protein Kinase Pathways in Human Rheumatoid Synovium Using the Severe Combined Immunodeficiency Mouse ModelJörg Schedel, Thomas Pap, Ulf Müller-Ladner, Renate E. Gray, and Steffen GayRetroviral Transduction of Antigen-Specific CD4+ T Cells for Local Delivery of Regulatory MoleculesGina L. Costa and C. Garrison FathmanGene Transfer to Lymphocytes Targeting Cartilagineous Collagen Type IIAlexander E. Annenkov and Yuti ChernajovskyGene Therapy in Murine Arthritis:
"It is indeed most helpful to those practicing Rheumatology. The author is a credible authority in the subject matter of the book...This book covers an exhaustive list of therapeutic topics. From familiar- such as Non Steroidal Drugs to unusual such as Apoptosis Regulation have been discussed in detail. Subjects such as Gene Therapy are especially well covered. The unique aspect of this book has to be its ability to discuss the latest knowledge in depth without losing sight of its primary objective; examining its clinical applicability...this book will prove to be of incomparable value; especially to practicing rheumatologists. It lays forth clearly what can be offered to the patient and why it may be of benefit when faced with the bewildering choices of therapeutic options available today. There are really no other books quite like it." -Doody's Health Sciences Book Review Journal
"This book could not have been published at a better time from the rheumatology trainee's point of view. It is written in a coherent and concise manner, which serves as an excellent source for all aspects of therapeutics in the rheumatic diseases. Furthermore, the frequent use of diagrams and graphs allowed emphasis of key points. This publication links the basic science of rheumatic diseases to a comprehensive text of therapeutic mechanisms and efficacy." -The Journal of Rheumatology
Inhaltsverzeichnis
I. Rheumatoid Arthritis
Larry W. Moreland, Section Editor
New Treatment Opportunities for Rheumatoid Arthritis
Larry W. Moreland
Genetic Influences on Treatment Response in Rheumatoid Arthritis
S. Louis Bridges, Jr. and Robert P. Kimberly
Nonsteroidal Anti-Inflammatory Drugs in the Treatment of Rheumatoid Arthritis
John S. Sundy
Additional Considerations on the Use of Nonsteroidal Anti-Inflammatory Drugs
M. Elaine Husni and Lee S. Simon
Glucocorticoid Therapy in Rheumatoid Arthritis
Kenneth G. Saag and John R. Kirwan
Anti-Tumor Necrosis Factor Agents
Alan K. Matsumoto and Joan M. Bathon
Interleukin-1 Receptor Antagonist Treatment in Rheumatoid Arthritis
Barry Bresnihan
Leflunomide: An Immunomodulatory Drug for the Treatment of Rheumatoid Arthritis
Paul Emery, David L. Scott, and Vibeke Strand
Matrix Metalloproteinase Inhibitors as Therapies for Rheumatoid Arthritis
Sean J. Wollaston and Kenneth C. Kalunian
Combination Disease-Modifying Anti-Rheumatic Drug (DMARD) Therapy
James R. O'Dell
Experimental Therapeutics for Rheumatoid Arthritis
Mark C. Genovese and William H. Robinson
II. Osteoarthritis
Jean-Pierre Pelletier and Johanne Martel-Pelletier, Section Editors
Slow-Acting Drugs for the Treatment of Osteoarthritis
Jean-Yves Reginster and Roy D. Altman
Intra-Articular Therapy in Ostheoarthritis
Boulos Haraoui and Jean-Pierre Raynauld
Promoting Articular Cartilage Repair
Joseph A. Buckwalter and James A. Martin
Using Molecular Markers to Monitor Osteoarthritis
Ivan G. Otterness and Mary J. Saltarelli
New Therapeutic Targets for Osteoarthritis: The Rewards of Research
Jean-Pierre Pelletier, Johanne Martel-Pelletier, and Pamela Manning
Recent Developments in the Therapy of Osteoarthritis
Jean-Pierre Pelletier and Johanne Martel-Pelletier
III. Systemic Autoimmune Diseases
Gary M. Kammer and George C. Tsokos, Section Editors
Treatment of Systemic Lupus Erythematosus
Peter H. Schur and Gary M. Kammer
Treatment of the Antiphospholipid Syndrome
Joan T. Merrill
Treatment of Systemic Lupus Erythematosus by Blocking T-Cell Costimulation
David I. Daikh and David Wofsy
Current Management of Systemic Sclerosis
Clarence W. Legerton III and Richard M. Silver
Sjögren's Syndrome
Robert W. Hoffman and Eric L. Greidinger
Mixed Connective Tissue Disease
Robert W. Hoffman and Eric L. Greidinger
Vasculitis
Dimitrios Vassilopoulos and Leonard H. Calabrese
Treatment of Juvenile Rheumatoid Arthritis
Laura J. Mirkinson and Ildy M. Katona
Treatment of Inflammatory Myopathies
William R. Gilliland
Psoriatic Arthritis
Dimitrios T. Boumpas and Gabor G. Illei
Complement Inhibitors in Rheumatic Diseases
Sherry D. Fleming and George C. Tsokos
Hematopoietic Stem Cell Transplantation of Autoimmune Disease
Richard K. Burt and Ann E. Traynor
IV. Gene Therapy in Rheumatic Diseases
Steffen Gay, Section Editor
Vectors for Gene Delivery
Sandro Rusconi and Maurizio Ceppi
Gene Targeting of Cytokines and the Mitogen-Activated Protein Kinase Pathways in Human Rheumatoid Synovium Using the Severe Combined Immunodeficiency Mouse Model
Jörg Schedel, Thomas Pap, Ulf Müller-Ladner, Renate E. Gray, and Steffen Gay
Retroviral Transduction of Antigen-Specific CD4+ T Cells for Local Delivery of Regulatory Molecules
Gina L. Costa and C. Garrison Fathman
Gene Transfer to Lymphocytes Targeting Cartilagineous Collagen Type II
Alexander E. Annenkov and Yuti Chernajovsky
Gene Therapy in Murine Arthritis:
Klappentext
Leading clinicians and clinical researchers discuss in practical detail the newest treatments used in rheumatic diseases, emphasizing-without neglecting current standard treatments-those experimental therapies now undergoing clinical trials and poised for early introduction into the rheumatology armamentarium. The diseases and therapeutic regimes examined here range from rheumatoid arthritis and its treatment by gene therapy, to osteoarthritis and systemic autoimune diseases. Each chapter is organized so that the busy clinician can quickly obtain all the information needed optimal patient treatment. This includes an analysis of the pathogenic mechanisms that explain the molecular basis of the newer therapeutics, reviews of animal data and the results of clinical trials, and recommendations concerning use, side effects, and precautions.
Includes supplementary material: sn.pub/extras
