Session 1 Bone Marrow, B Cell Differentiation, and the B Cell System.- Chairman's Introduction: Bone Marrow and B Cell Differentiation.- Migration of Erythropoietic and Prebursal Stem Cells from the Early Chicken Embryo to the Yolk Sac.- Antigens Associated with Bursal and Thymic Reticular Epithelial Cells.- The Development of B Lymphocytes and Their Reactivity in Pig Fetuses.- Regulation of B Cell Development in Mouse Bone Marrow.- Distribution and Functional Properties of PNA+ and PNA- Cells in Central and Peripheral Lymphoid Organs of the Chicken.- Peanut Agglutinin (PNA) Binding as a Marker for Immature Human B Lymphocytes. Is Bone Marrow Not the Complete Bursa-Equivalent?.- Functional Studies on Subpopulations of B-Lymphocytes and Bone Marrow Cells.- Human Sessile B Lymphocyte Marker Defined by a Monoclonal Antibody.- Marginal Zones: The Largest B Cell Compartment of the Rat Spleen.- The Proliferative Activity of Antibody Forming Cells in the Mouse Bone Marrow.- The Origin of Marginal-Zone Cells.- Functional Antigen Binding by the Defective B Cells of CBA/N Mice.- The Role of Bursal Microenvironment in the Maturation of B Cells.- Fluorescence Activated Cell Sorter Analysis of Murine B Cell Development.- Pre B Cell Leukaemia in the Rat.- Differences in In Vivo Functional Capacities of Avian Precursor B and T Cells Following In Vitro Incubation.- Lymphoid Antigens on Non-lymphoid Factor-Dependent Haemopoietic Cell Lines.- Session 2 Lymphocyte Migration.- Chairman's Introduction: Experimental Approaches to Lymphocyte Traffic: Pitfalls of the Tracer Sample Method.- Two Populations of Murine LPS-Responsive B Lymphocytes Differing in Recirculatory Capacity.- A Method for Studying the Dynamics of the Primary Migration of Human Lymphocytes Using Indium-III Oxine Cell Labelling.- LYT Phenotype and Lectin Binding Properties of Mouse Lymphocytes Which Enter Lymph Nodes.- Unilateral Localization of Hapten-Specific B Memory Cells in Lymph Node Draining A Footpad Injection of Antigen.- Organ-Specific Homing of B Cell Hybridomas.- Isolation of Factors Causing Enhanced Lymphocyte Adherence to High Endothelial Venules In Vitro.- Lymphocyte-Endothelial Interactions and Histocompatibility Restriction.- Selective Migration of Murine Lymphocytes and Lymphoblast Populations and the Role of Endothelial Cell Recognition.- The Effect of Stimulated Macrophages on High Endothelial Venules and Germinal Centres in Lymph Nodes of Rat.- Homing Pattern of Newly Formed Splenic Lymphocytes.- The Efficiency of Entry of Lymphoid Cells into Lymphoid and Non-lymphoid Tissues.- Morphological Aspects of the Local Immune Response to Influenza in Rats.- Session 3 Thymus, T Cell Differentiation, and the T Cell System.- Chairman's Introduction: Thymus, T Cell Differentiation and the T Cell System.- Detection of MHC, THY-1, LYT-1 and LYT-2 Antigens in the Developing Mouse Thymus.- Role of Thymic Medullary Lymphocytes in the Intra-Thymic Maturation Process.- Sequential Development of THY-1+ Subpopulations in Regenerating Thymus After Bone Marrow Transplantation.- "Thymic Nurse Cells" Contain the First Virus Producing Cells After Inoculation of the Radiation Leukemia Virus in C57BL/Ka Mice.- Studies on the Maturity of Cells Migrating From the Thymus to the Periphery in Mice.- Lymphocytes in Mice with Membrane Antigens Common to Human Thymocytes.- Cloned T Cell Progenitors From Mouse Bone Marrow Give Rise to Lymphocytes with Multiple Anti-H-2 Reactivities.- Frequency and Restriction of Cytotoxic T Lymphocyte Precursors in Neonatally Thymectomized Mice.- Accumulation of Mature T and B Cells and Abnormalities of Lymphocyte Traffic in the Thymus of Aged NZB × SJL F1 Female Mice.- Structural and Functional Alterations of the Aging Human Thymus.- Study of Beta Adrenoceptors on Subpopulations of Thymocytes Separated on Ficoll-Hypaque Density Gradients.- Lymphocyte Differentiation in the Rabbit Thymus.- Monoclonal Antibodies Against Rat T Cells.- Ontogeny of the Immune Sy
In 1966, the first Germinal Centre Conference was held in Bern, Switzerland, as a result of an initiative from C. C. Longdon of Oak Ridge, Tennessee and H. Cottier of Bern. Fifteen years later, in June of 1981, the 7th conference in this series was held in Groningen, the Netherlands. At this "International Conference on Lymphatic Tissues and Germinal Centers in Immune Reactions," instead of focusing on germinal centres only, the intricate relationships between various constituents of the lympho-myeloid complex consti tuted the theme of the meeting. As Yoffee stated in 1966, "Perhaps we should consider not only the germinal centre itself but the surrounding tissue as well. " Over the years, these conferences have brought together a small but dedicated group of scientists, sharing (1) a fundamental interest in the physiology of the lymphoid system proper, and (2) the recognition that, only in the in vivo situation can the final answers be obtained, however ingeniously in vitro experiments may mimic reality. In 1966, the conference lasted three days and included 57 contributions "which were discussed at length. " The present conference accomodated 62 free papers and 64 poster presentations as well as some 24 additional abstracts selected from more than 200 submissions. Prominent among the selection criteria was the adage "in vivo veritas. " This volume represents the presentations from the 1981 Germinal Centre Conference.
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