I. Urinary Tract Infection; Infectious and Non-Infectious Tubulointerstitial Nephritis.- Identification and Documentation of Urinary Tract Infection.- Bacteriology of Urinary Tract Infection.- Highlights Pathology and Interstitial Nephritis.- Acute and Chronic Urinary Tract Infection.- Panel Discussion.- Reflux Nephropathy.- Highlights Role of Reflux in Renal Damage.- Highlights Segmental Hypoplasia with Hypertension (Ask-Upmark Kidney).- Highlights Glomerular Involvement Secondary to Vesico-ureteral Reflux (VUR).- Treatment of Bacterial Urinary Tract Infection in Childhood.- Panel Discussion.- Immunologically Mediated Tubular and Interstitial Nephritis.- Highlights Immunologically Mediated Tubulointerstitial Nephritis in Children.- Highlights Acute Non-bacterial Tubulointerstitial Nephritis (TIN).- Newer Nephrotoxic Agents.- Case Report Renal Failure Associated with Hydantoins Administration in Nutritional Rickets.- Panel Discussion.- Workshop: Clinicopathologic Correlations.- II. Nutritional Aspects of Renal Disease.- Highlights Relation of Cell Metabolism to Nutritional State.- Water and Electrolytes in Malnourished and Uremic Children.- Serum Nutrient Alterations in Chronic Renal Disease.- Highlights Plasma and Muscle Free Amino Acid Alteration in Uremic Children.- Panel Discussion.- Nutritional Aspects of Chronic Renal Disease in Children.- Nutrient Requirements.- Hyperlipidemia Secondary to Renal Disease.- Aluminum in Chronic Renal Failure: A Pediatric Perspective.- Highlights Long Term Constant Rate Enteral Nutrition in Children with Renal Disease.- Highlights Cell Metabolic Responses to Amino Acid Infusions in Chronic Uremia.- Panel Discussion.- III. Systemic Aspects of Renal Disease.- Renal Osteodystrophy: Pathogenesis, Prevention and Treatment.- Hypertension of Renal Origin in Childhood.- Usage of Antibiotics in Children with Renal Insufficiency.- Panel Discussion.- Principles of Diuretic Therapy in Edematous Conditions.- Peritoneal Dialysis Kinetics: A Pediatric Perspective.- Panel Discussion.- Workshop: Immuno-Clinico-Pathological Correlations.- Participants.- Author Index.
Infectious and non-infectious tubulointerstitial nephropathies are old subjects but there is enough confusion and disagreement on terminology and etiopathogenesis to warrant a new look at these problems. We were fortunate in having at the Pediatric Nephrology Seminar 6 and as contributors to this volume, the representative- or shall I say "originators"? - of each of the three most identifi able positions: Dr. Renee Habib - congenital anomalies, Dr. John Hodson - reflux, and Dr. Robert Heptinstall - infection. Although some tend to hold onto one position and exclude others, in this case there was overlapping of perception. Dr. Habib accepts a role for infection in reflux and for infection in the presence of obstruc tion; Dr. Hodson accepts infection and congenital anomalies as modi fiers; and Dr. Heptinstall takes an overall position whicm encompas ses the three. Thus the first part of the book emphasizes the complexity of something as seemingly simple as UTI and demonstrates awareness of disagreement even among the pros about meanings, interpretations, and treatment. Drs. Gustavo Gordillo, Jorge de la Cruz and their associates emphasize the importance of predisposing factors for UTI; Dr. Materson focuses on the workup of the patient, Dr. Zillerueloon bacteriological aspects, and Dr. Gorman on treatment approaches. Dr. Vaamonde reviews nephrotoxic agents. Finally, Drs. Andres and Noble review the immunological aspects of various tubulointer stitial nephritides.
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