Developmental and Phylogenetic Aspects of the Cholinergic Neurone.- Acetylcholine Biosynthesis in Developing Cholinergic Synapses.- Aging of Cholinergic Synapses in the Peripheral Autonomic Nervous System.- The Chemical Embryology of the Electromotor System of Torpedo Marmorata.- The Regional Distribution of Acetylcholine,Cholin-Acetyltransferase, and Acetylcholinesterase in Vertebrate Brains of Different Phylogenetic Levels.- Choline Uptake and Choline Acetyltransferase in Brain of Developing Rats Made Hypothyroid With Propylthiouracil.- Morphological Analysis of Chick Embryo Heart Development.- Placental Choline Acetyltransferase Purification and Properties.- Peripheral Cholinergic Synapses: Ganglia.- The Relationship Between Choline Uptake and Acetylcholine Synthesis in a Sympathetic Ganglion.- Multiple Mechanisms In Ganglionic Transmission.- PGE1-Induced Camp Biosynthesis in the Superior Cervical Ganglion of Different Animal Species.- Questions Raised by the Electron Microcopic Localization of Acetylcholinesterase and Butyrylcholinesterase in Normal and Denervated Superior Cervical Ganglia in the Cat.- Acetylcholine Metabolism in PCl2, A Clonal Cell Line on Secretory Cells.- Regulation of Cholinergic Transmission in Adrenal Medulla.- Effect of Latrodectus Mactans Tredecimguttatus Venom on Synaptic Transmission of Chicken Ciliary Ganglion In Vitro.- Peripheral Cholinergic Synapses: Heart, Myenteric Plexus and Neuromuscular Function.- Regulation of Acetylcholine Synthesis and Release in the Isolated Heart.- Modulation by Scopolamine, Acetylcholine and Choline of the Evoked Release of Acetylcholine from the Guinea Pig Myenteric Plexus: Evidence for a Muscarinic Feedback Inhibition of Acetylcholine Secretion.- Kinetic Studies on the Release of [3H]-Acetylcholine from Guinea Pig Myenteric Plexus: Difference in the Effects of Morphine and Reduced Calcium Influx.- Na+-K+-Activated ATPase and Non-Quantal/Cytoplasmic Release of Acetylcholine.- Hydrolysis of Acetylcholine by Frog Skeletal Muscle.- Early Effects of Denervation on Acetylcholine and Choline Acetyltransferase in Skeletal Muscle.- Release of Acetylcholine Triggered by the Venom of Glycera Convoluta.- Electrophysiological and Morphological Correlates of the Re-Innervation of Rat Neuromuscular Junction: Implications on the Role of Membrane Components such as Gangliosides in the Motor Nerve Sprouting.- Isolation of Synaptic Vesicles from the Myenteric Plexus of Guinea Pig.- Peripheral Cholinergic Synapse: Presynaptic Mechanisms.- The Structure of Cholinergic Synaptic Vesicles.- Inhibition of Membrane Transport Systems in Synaptosomes from Torpedo Electric Organ by Snake Neurotoxins.- Biochemical and Biophysical Aspects of Stimulation Induced Vesicle Heterogeneity in Cholinergic Synaptic Vesicles.- Acetylcholine Storage and Calcium Clearance by Synaptic Vesicles.- Acetylcholine Changes During Transmission of a Single Nerve Impulse.- Uptake of Acetylcholine into Torpedo Synaptic Vesicles in Vitro.- A Vesicular Site of Origin for the Release of a Cholinergic False Transmitter at the Torpedo Synapse.- Transmembrane Potential and Cation Diffusion Gradients in Isolated Cholinergic Synaptic Vesicles: Possible Model for Energization of Vesicular Acetylcholine Uptake.- Incorporation of Acetate into Acetylcholine and Other Compounds in the Torpedo Electric Organ.- Peripheral Cholinergic Synapse: Postsynaptic Aspects.- Cholinergic Receptor Isolation.- New Evidence for True Immunopharmacologic Blockade in Myasthenia Gravis.- Immunohistochemical Demonstration of IgG and Fab Fragments at Motor Endplates of Passively Transferred Mice.- On the Effects of Anticholinergic Agents on Muscarinic Receptors of Different Localization.- Peripheral Cholinergic Synapse: Axonal Aspects.- Ligand Interactions of Axonal Membranes.- Axonal Transport of Phosphoglycerides To Cholinergic Synapses.- Acetylcholinesterase and Butyrylcholinesterase: Similarities in Normal and Denervated Muscles, Differences
Every three years early Spring witnesses the convening of a small group of neuroscientists from many parts of the world. They are devoted to the study of acetylcholine, the oldest of the known neurotransmitters. To assess the level of knowledge, to take stock of the still unsolved problems, to evaluate the practical meaning of their findings, the cholinologists first met in 1969 in the eerie atmosphere of a snow-covered Swedish forest, the second in the Swiss Alps, the third facing the surf and foam of the Paci fic waves. Finally in March 1980 Florence, her trees burgeoning in the mild rain of March, confronted them with the temptation of her monuments and museums. But the cholinologists bravely dismis sed the temptations and went on with the presentations and discus sions of the many papers which form the present book. The papers describe the most recent development of investiga tions on acetylcholine. They open with an extensive coverage of the developmental and phylogenetic aspects of the cholinergic neurons. The regulation of acetylcholine synthesis, release, post synaptic, electrical and trophic effects in the peripheral chol inergic synapses including ganglia, neuromuscular junction, myen theric plexus and heart is then covered. Special emphasis is given to the cholinergic mechanisms in the eye.
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