Morphology.- Three Types of Granule Formed in Guinea Pig and Rat Heterophil Granulocytes.- Locomotion of Phagocytes.- Leucocyte Activation and the Assessment of Leucocyte Locomotion and Chemotaxis.- Distribution of Actin-Binding Protein and Myosin in Neutrophils During Chemotaxis and Phagocytosis.- Interaction Between Neutrophils and Mediators of Inflammation.- A Short Transient Increase in Cyclic Adenosine 3?, 5?-Monophosphate Levels of Neutrophil Granulocytes Following Exposure to Chemotactic Factors.- Neutrophil Migration and Orientation Under Agarose: Findings in Patients With the Immotile Cilia Syndrome and Effects of Cytochalasin B and Vinblastine.- Cytotoxic Activity of Phagocytes.- A Differential Responsiveness of In Vitro Differentiating Mononuclear Phagocytes From Bone Marrows of Normal and Inflamed Mice to Lymphokines and Poly I · Poly C.- The Oxygen-Dependent Antibody-Dependent Cell-Mediated Cytotoxicity of Human Monocytes and Neutrophils.- Macrophage Activation for Tumor Cytotoxicity: Reactivity of Peritoneal and Bone Marrow Macrophages.- Cytotoxicity on Tumor Cells of Human Macrophages: Functional Status of Tumor-Associated Effector Cells.- Studies on the Recognition of Xenogeneic Cells by Nonimmune Macrophages. II. Separate Signals Triggered by Cytostasis and Cytolysis.- Genetic Aspects of Macrophage Activation for Tumor Cytotoxicity.- Microbicidal Activity of Phagocytes.- O2-Independent Killing of Gram-Negative Bacteria by Intact Granulocytes. The Role of a Potent Bactericidal Membrane-Perturbing Protein.- The Extracellular Stimulation of Intracellular Killing by Phagocytes.- Molecular Mechanism of the Bactericidal Action of Myeloperoxidase-H2O2 -Chloride.- The Role of the Cell Membrane in the Killing Mechanism of Polymorphonuclear Leucoctyes (PMN).- Leptospires Macrophage Interactions.- Relationship Between the Enchanced Oxidative Metabolism and the Enhanced Microbicidal Activity of Activated Macrophages.- Release of Superoxide Anion and Enhanced Candidacidal Activity as a Manifestation of Macrophage Activation: Studies with Muramyl Dipeptide.- Killing of Leishmania donovani Amastigotes by Murine Macrophages.- Selective Depression of Phagocytes Intracellular Killing Activity.- Secretory Activity of Phagocytes.- Modulation of the Inflammatory Response by the Neutrophil Myeloperoxidase System.- Elastase Secretion by Mouse Peritoneal Macrophages: Effects of Rifampin and Corticosteroids.- Synthesis and Release of Factor Increasing Monocytopoiesis (FIM) by Macrophages.- Biochemical and Biological Characteristics of Leucocyte Proteinase Inhibitors.- Oxidative Damage to Lysosomal Enzymes in Human Phagocytosing Neutrophils.- The Release of Platelet-Activating Factor During Phagocytosis by Polymorphonuclear Neutrophils and Monocytes.- The Secretion of Lysosomal Enzymes by Human Polymorphonuclear Leucocytes (PMN) and Its Modulation by Serum Complement.- The Bovine Neutrophil: Separation and Partial Characterization of Plasma Membrane and Cytoplasmic Granules.- Biochemistry of Phagocytes.- The Respiratory Burst of Phagocytic Cells: Facts and Problems.- Discrepancies in the Oxygen Balance of Whole Human Neutrophils and Neutrophil Homogenates.- Neutrophil Activation Studied Using Two Indirect Probes of Membrane Potential Which Respond by Different Fluorescence Mechanisms.- Apparent Km of Leukocyte O2? and H2O2 Forming Enzyme for Oxygen.- Formation of Superoxide Anions and Hydrogen Peroxide by Polymorphonuclear Leukocytes Stimulated With Cytochalasin.- Hydrogen Peroxide Production in a Cell-Free System: Evidence for the Involvement of a Chain Reaction.- The Respiratory Burst in Human Polymorphonuclear Leucocytes Stimulated by Particles.- Stimulation of the Hexose Monophosphate Shunt Activity in Human Polymorphonuclear Leukocytes.- The Nature and Function of the Microbicidal Oxidase System of Neutrophils.- Chemiluminescence and the Study of Phagocyte Redox Metabolism.- An Alternative Mechanism for the Production of Hydroxyl Radicals by Stimulated Neutrophils.- Superoxide Dismutases and the Oxidative Burst in Human Blood Polymorphonuclear Leukocytes.- Role of Serine Proteases in Superoxide Production by Human Neutrophils, Monocytes and Basophils.- Release of the Membrane-Calcium and its Relation to the Superoxide Formation by Polymorphonuclear Leukocytes.- ATP-Driven Ca2+ Pump Activity of Macrophage and Neutrophil Plasma Membrane.- Ca2+ Transport and Surface Membrane ATPase in Macrophages.- Effect of Ionophores on Lymphocyte Cellular Metabolism.- Peroxidatic Activity Distinct from Myeloperoxidase in Human Monocytes Cultured in Vitro and in Alveolar Macrophages.- Characterization of the Peroxidase in Human Eosinophils.- Stimulation or Activation of Eosinophils in Vivo During Eosinophilia: Possible Role of Arachidonic Acid Metabolism.- Factors Affecting Phagocyte Functions.- Platelet Leukocyte Interactions II In-Vivo Correction of Chediak-Higashi Leukocyte Function with Serotonin or Normal Platelets.- Physicochemical Surface Changes on Phagocytic Cells During Differentiation in Relation to Chemotaxis and Phagocytosis.- Mechanism of Hexose Transport in Human Polymorphonuclear Leukocytes.- Tuftsin and Substance P as Modulators of Phagocyte Functions.- The Effect of Hyaluronic Acid on Neutrophil Function in Vitro and in Vivo.- Expression of Fc and C3b Receptors and Intracellular Distribution of Bacteria in Rat Macrophages.- Monocyte Activation by Immune Complexes of Patients with SLE.- Clinical Aspects of Phagocyte Functions.- Nucleotide Concentrations in Leucocytes and Their Use in Controlling the Quality of Cell Preparations.- Resting and Stimulated Chemiluminescence of Polymorphonuclear Leukocytes: A Clinical Approach.- Deficient Phagocytosis Secondary to Breakdown of Opsonic Factors in Infected Exudates.- Congenital and Acquired Lactoferrín Deficiencies in Neutrophils.- Functional and Metabolic Abnormalities of Diabetic Monocytes.- Enzymatic Deficiency in Monocytes from Patients with Chronic Granulomatous Disease.- Use and Results of Neutrophil Function Testing in Pediatric Immunology.- The Effect of Influenza Virus on Oxygen-Dependent Metabolism of Human Neutrophils.- Chronic Granulomatous Disease, Kx Negative Neutrophils and Linkage with Xg.- Round Table on the Clinical Application of Leucocyte Function Tests.- Contributors.
This volume collects the papers presented at the "Second Euro pean Conference on Phagocytic Leucocytes" which was held in Trieste, September 15-18, 1980. The Conference was the continuation of the thread of a discourse initiated with the "First European Conference on Phagocytic Leucocytes," which was held also in Trieste in 1976. In fact, in both Conferences the biochemical aspects of the basic functions of phagocytes--that is movement, metabolism, secretion, and bactericidal activity--were mainly emphasized. In the Second Confer ence, two additional subjects were also dealt with, and those are the tumoricidal activity of phagocytes and the clinical aspects of phagocyte functions. In connection with the latter subject a "Round Table on the Clinical Application of Leucocyte Function Tests" was held during the Conference, and the proceedings are reported in this book in the hope that they may be useful to those who are interested in the relationship between phagocytes and diseases. The number of papers which are being published concerning the phagocytic process is such that one wonders whether publication of a new book in this field is necessary. However, the philosophy which inspired the edi ting of this book differs from that underlying publication of origi nal articles in scientific journals. We started from the common notion that the real progress of our knowledge is not necessarily proportional to the amount of published material in that specific field.
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