1 Workshop Overview.- 2 Quantitating Atherosclerosis: Problems of Definition.- 1 Critical Review of Current and Prospective Quantitative Methods for Evaluating Atherosclerosis.- 3 Atherosclerosis Quantitation by Computer Image Analysis.- Discussion.- 4 Morphology: Morphometric Analysis of Pathology Specimens.- 5 Physical Biochemistry of the Lesions of Man, Subhuman Primates, and Rabbits.- Discussion.- 6 Angiography in Experimental Atherosclerosis: Advantages and Limitations.- Discussion.- 7 Digital Intravenous Subtraction Angiography.- Discussion.- 8 Quantitative Evaluation of Atherosclerosis Using Doppler Ultrasound.- Discussion.- 9 B-Mode Ultrasound Interrogation of Arteries.- Discussion.- 10 Radionuclide and Nuclear Magnetic Resonance Methods of Evaluating Atherosclerosis.- Discussion.- 2 Critical Review of Correlation and Validation Studies for Evaluating Atherosclerosis.- 11 Correlation of Lesion Configuration with Functional Significance.- Discussion.- 12 Correlation of Antemortem Angiography with Pathology.- Discussion.- 13 Correlation of Postmortem Angiography with Pathologic Anatomy: Quantitation of Atherosclerotic Lesions.- Discussion.- 14 Correlation of Doppler Ultrasound with Arteriography in the Quantitative Evaluation of Atherosclerosis.- Discussion.- 15 Correlation of B-Mode Ultrasound of the Carotid Artery with Arteriography and Pathology.- Discussion.- 16 Correlation of Morphological and Biochemical Components of Atherosclerotic Plaques.- Discussion.- 17 Multicenter Trial for Assessment of B-Mode Ultrasound Imaging.- Discussion.- 3 Critical Review of Measurements of Change in Atherosclerosis Progression and Regression.- 18 Pathobiology of Atherosclerosis.- Discussion.- 19 Animal Studies of Atherosclerosis Progression and Regression.- Discussion.- 20 Human Studies of Progression and Regression.- Discussion.- 21 Coronary Angiography Quality Control in the CASS Study.- Discussion.- 22 Vessel Injury, Thrombosis, and the Progression and Regression of Atherosclerotic Lesions.- A Discussion of Platelet Thrombi in Atherogenesis: M. Dania Haust.- 23 Review of Clinical Studies on the Quantification and Progression of Atherosclerosis.- Discussion.- 24 Experimental Design Problems: Interpretation of Statistical Arithmetic.- Discussion.- 4 Summary.- 25 Universal Reference Standards for Measuring Atherosclerotic Lesions: The Quest for the "Gold Standard".- 26 Recommendations.
This volume is the product of a February 1982 conference, cosponsored by the American Heart Association, the National Institutes of Health, and the Bowman Gray School of Medicine, which examined techniques for delineating quantitatively the natural history of atherosclerosis. Against the background of current pathologic and clinical knowledge of atherosclerosis, invasive and noninvasive evaluative methods now in use and under development are surveyed in depth. Correlative clinicopathologic studies of atherosclerosis pose special questions with respect to both luminal and plaque characteristics that are addressed in this volume. An old observa tion, based on the examination of arterial casts, suggested that the so-called nodose lesion of atherosclerosis may be at first flattened into the wall of a weakened, dilated artery, rather than raised into the lumen. This is now fully confirmed in vivo by ultrasonic and other imaging techniques. The morbid anatomist is challenged anew to describe lesions as they are likely to occur in vivo. To achieve closer correlation with natural conditions, perfu sion fixation of arteries under arterial pressure is becoming more widely used and has already demonstrated more valid quantita tion of the composition and configuration of lesions. While the noninvasive methods of B-mode and Doppler ultrasound are suitable only for the clinical study of superficial arteries, such as the carotid or femoral, the new and relatively noninvasive procedure of intravenous digital subtraction angio graphy can be effectively used for the examination of deep systems, such as cerebral vessels.
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