Session I. Tryptophan and its Metabolites: Chemical and Analytical Issues.- Retro-, Intro- and Perspectives of Trypto-Fun.- Tryptophan and Related Alkaloids.- Stability of Tryptophan in Peptides Against Oxidation and Irradiation.- Mass Spectrometric Determinations of Tryptophan and its Metabolites.- Signal-to-Noise Optimization of HPLC-Fluorometric Systems and their Application to the Analysis of Indoles.- Brain Indole Metabolism Assessed Using in vivo Dialysis.- Sub-Picogram Determination of Serotonin Using HPLC with Electrochemical Detection for Microdialysis Studies of Serotonin Release.- Session II. Tryptophan Metabolism: Serotonin and Melatonin.- Autoradiographic Measurement of the Rate of Serotonin Synthesis in the Rat Brain.- Autoradiographic Studies of 5HT2 Receptors.- Ambivalence on the Multiplicity of Mammalian Aromatic L-Amino Acid Decarboxylase.- Interrationships of DNA Cycles and Melatonin Synthesis.- Regulation of Melatonin Synthesis in the Ovine Pineal Gland.- Melatonin Synthesis: Multiplicity of Regulation.- Session III. Tryptophan Metabolism: Kynurenines.- The Role of Tryptophan and Kynurenine Transport in the Catabolism of Tryptophan Through Indoleamine 2,3-Dioxygenase.- Kynureninase and Kynurenine 3-Hydroxylase in Mammalian Tissues.- Relationships Between Pteridine Synthesis and Tryptophan Degradation.- Quinolinic acid and Kynurenic acid in the Mammalian Brain.- Kynurenate Forming Enzymes in Liver, Kidney and Brain.- Regulation of Pyridine Nucleotide Coenzyme Metabolism.- Session IV. Biological Effects: Serotonin and Melatonin.- Serotonin: Its Role and Receptors in Enteric Neurotransmission.- Mechanisms of Serotonergic Affect Control.- Neuroendocrine Responses to L-Tryptophan as an Index of Brain Serotonin Function: Effect of Weight Loss.- Melatonin Receptors in the Central Nervous System.- Melatonin Interaction With the Benzodiazepine-GABA Receptor Complex in the CNS.- Session V. Biological Effects: Tryptophan and Kynurenines.- Effects of Tryptophan 2,3-Dioxygenase Inhibitors in the Rat.- Bidirectional Relationships Between Tryptophan and Social Behavior in Vervet Monkeys.- The Regulation of Brain Kynurenic Acid Content: Focus on Indole-3-Pyruvic Acid.- Physiological Role of 3-Hydroxykynurenine and Xanthurenic Acid Upon Crustacean Molting.- Kynurenines in the Regulation of Behavior in Insects.- Effects of Quinolinic and Kynurenic Acids on Central Neurons.- Behavioral Abnormalities in Rats After Single Treatment with Quinolinic Acid During Early Ontogenesis.- Tryptophan Nutrition and Metabolism: An Overview.- Comparison of Tryptophan Metabolism In Vivo and in Isolated Hepatocytes from Vitamin B6 Deficient Mice.- Effects of the Diet and other Metabolic Phenomena on Brain Tryptophan Uptake and Serotonin Synthesis.- Effects of Tryptophan and of 5-Hydroxytryptamine Receptor Subtype Agonists of Feeding.- The Role of Serotonin (5-HT) in Feeding Responses to Amino Acids.- Session VII. Clinical Aspects.- Cardiovascular and Endocrine Properties of L-Tryptophan in Combination With Various Diets.- Acute Effects of Meals on Brain Tryptophan and Serotonin in Humans.- Implications of Interferon-induced Tryptophan Catabolism in Cancer, Autoimmune Diseases and AIDS.- Induction of Indoleamine 2,3-Dioxygenase in Tumor Cells Transplanted into Allogeneic Mouse: Interferon-? is the Inducer.- Short Communications.- Plasma Free 5HT, Plasma 5HIAA and Whole Blood 5HT in the Rat.- Effects of Clomipramine on Extracellular Serotonin in the Rat Frontal Cortex.- Tryptophan Metabolism in Senile Cataract Assessed Patients by High-Performance Liquid Chromatography.- The Effect of Aluminum on Rat Brain and Liver Quinolinic Acid Concentrations.- Kynurenine and Lipid Metabolism.- Content of Tryptophan in Human Hair.- Detection of a New Intermediate Product of Indolealkylamine Metabolism in the Brain.- The Excretion of N1-Methyl-2-pyridone-5-carboxylic Acid and Related Compounds in Human Subjects After Oral Administration of Nicotinic Acid,
The 6th triennial meeting of the International Study Group for Tryp tophan Research (ISTRY) was held May 9-12, 1989 in Baltimore, Maryland (USA). From the wide variety of topics and disciplines represented, as documented in this volume, it is clear that tryptophan research and ISTRY are alive and well. ISTRY traces its or1g1ns to at a tryptophan symposium organized in 1971 by H. Schievelbein at Hohenried near Munich (Germany). Up to that time there had been occasional international tryptophan conferences at irregular inter vals. A number of participants at the Hohenried meeting felt that an inter national tryptophan organization should be formed to organize regular meet ings and to foster collaboration and information exchange on tryptophan-re lated topics. Thanks mainly to the founding work of H. Schievelbein and W. Kochen, an executive committee was elected and ISTRY was born. The inaugural meeting in 1974 was held in Padova (Italy) to honor L. Musajo, one of the foremost pioneers in tryptophan studies. This first ISTRY meeting was suc cessfully organized by L. Musajo, G. Allegri, A. De Antoni, and C. Costa, and was critical in assuring the viability of the new organization. Subsequent meetings were held in 1977 in Madison, Wisconsin (USA), organized by R.R. Brown, D.P. Rose, and W.E. Knox, honoring C.P. Berg; 1980 in Kyoto (Japan), organized by O. Hayaishi, R. Kido, Y. Ishimura, T. Deguchi, T. Hino, T.
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