Signal Transduction and Protein Kinase C.- Molecular pharmacology of protein kinase C.- Protein kinase C in cell growth and differentiation.- Roles of protein kinase C isozymes in cellular regulation.- Activation of protein kinase C by short chain phospholipid micelles.- Inositol Phosphatides and Calcium Ion.- Inositol phosphate metabolism and cellular signal transduction.- Role of calcium released from the sarcoplasmic reticulum of smooth muscle cells as induced by inositol phosphatides.- Molecular Properties of the Calcium Pump.- The Calcium pump of the plasma membrane: structure-function relationships.- Identification of a synaptic membrane-localized isoform of the calcium-pumping ATPase.- Molecular structure and function of phospholamban: the regulatory protein of calcium pump in cardiac sarcoplasmic reticulum.- Sarcolemmal (Ca2+ + Mg2+)-ATPase of vascular smooth muscle.- Molecular Regulation of Calcium Channels.- Molecular properties of voltage-sensitive calcium channels.- Intracellular mechanisms involved in "run-down" of calcium channels.- A comparative study about voltage-dependent Ca currents in smooth muscle cells isolated from several tissues.- Two types of Ca channels in smooth muscle cells isolated from guineapig taenia coli.- Molecular Mechanisms Involved in Calcium Protein Signaling.- Molecular analysis of calmodulin and smooth muscle myosin light chain kinase.- Interaction between calmodulin and target proteins.- Activation of rabbit skeletal muscle myosin light chain kinase by calmodulin - A mechanistic overview.- Calcium signaling of calcium-binding proteins and drug actions.- Analysis of calcium-binding sites in calcium-activated neutral protease.- Neutralization of surface charges markedly affects the properties of bovine calbindin D9k.- Conformation of a troponin-I peptide bound to troponin-C as determined by 1H NMR.- Cooperativity in calcium binding and calcium dependent reactions.- Structure and function of parvalbumin.- Genes of Calcium-Binding Proteins.- Structural organization of calmodulin genes in the rat genome.- The human calbindins: cDNA and gene cloning.- Structure of the rat vitamin D-induced calbindin-D9k gene and evolution of the EF-hand calcium-binding protein family.- Structural organization of the human parvalbumin gene.- Gene expression of a rat cerebellar Ca-binding protein, spot 35 protein.- Calspermin is a testis specific calmodulin-binding protein closely related to Ca2+/calmodulin-dependent protein kinases.- Regulation of Muscle Contraction.- Myosin and contractile activity in smooth muscle.- Second messenger effects on the myosin phosphorylation system in smooth muscle.- In situ phosphorylation of human platelet and rat basophilic leukemia cell (RBL-2H3) myosin heavy chain and light chain.- Effect of multiple phosphorylations on movement of smooth muscle and cytoplasmic myosin.- Regulation of embryonic smooth muscle myosin by myosin light chain kinase and by protein kinase C.- Cytoskeleton and Calcium Signaling.- Calcium and polyphosphoinositide regulation of actin network structure by gelsolin.- Significances of two different Mr caldesmons.- A model for caldesmon in latch-bridge formation in smooth muscle.- Protein Phosphatase and Calcium Signaling.- Characterization of the calmodulin-binding domain of calcineurin deduced from a complementary DNA clone.- The role of brain protein phosphatases 1 and 2A in the regulation of microtubule assembly.- Demonstration of different regional distribution of calcineurin subunits using monoclonal antibodies.- Stimulation by inositol trisphosphate and tetrakisphosphate of a protein phosphatase.- Calcium Ion and Cyclic Nucleotide Phosphodiesterases.- The domain structure of the calmodulin-dependent phosphodiesterase isozymes.- Regulation of the 63-kDa subunit-containing calmodulin-dependent cyclic nucleotide phosphodiesterase isozyme.- Molecular properties of cyclic nucleotide phosphodiesterase isozymes.- Calcium Signaling in Molecular Cell Biology.- Roles of calcium in the regulation of tyrosine hydroxylase.- Calbindin-D28 in mammalian brain, retina, and endocrine pancreas: immunohistochemical comparison with calretinin.- The calpain-calpastatin system in hematopoietic cells.- Role of anions in platelet intracellular calcium ion rise and arachidonic acid release induced by thrombin.- Frequency-dependent inhibition of the intracellular calcium transients by calmodulin antagonists in the aequorin-injected rabbit papillary muscle.- Calcium in mitosis: role of 51-kD protein in the centrosome of sea urchin egg in aster formation.- Conditional-lethal mutant of calmodulin in yeast.- Molecular Pathophysiology of Calcium Metabolism.- Human vitamin D receptor mutations: identification of molecular defects in hypocalcemic vitamin D resistant rickets.- Disregulation of cell calcium and calcium-binding proteins in experimental hypertension.- A possible mechanism for increments of calcium and protein kinase C activity in kidney of experimental acute fluorosis.- Author Index.
The Sixth International Symposium on Calcium-Binding Proteins in Health and Disease was held in Nagoya, Japan, July 24-28, 1988. Four hundred and seventy-two persons participated in this symposium. This large attendance is proof indeed of the growing interest in this field of research. Previous meetings were held in Jablonna, Poland in 1973; Ithaca, New York in 1977, Madison, Wisconsin in 1980; Trieste, Italy in 1983 and in Asilomar, California in 1986. The scientific program of this 1988 meeting included forty-one oral presentations given by invited specialists, ten round table presentations and one hundred and eighty-seven poster presentations. The program was set-up by the Organizing Committee and the members were Hidaka, H. (Japan), Forsen, S. (Sweden), Klee, C. B. (U. S. A. ), Means, A. R. (U. S. A. ), Norman, A. W. (U. S. A. ) and Sykes, B. D. (Canada). The members of the Advisory Committee, Carafoli, E. (Switzerland), Gergeley, J. (U. S. A. ), Kretsinger, R. H. (U. S. A. ), MacLennan, D. H. (Canada), Siegel, F. L. (U. S. A. ), Vanaman, T. C. (U. S. A. ), Wasserman, R. H. (U. S. A. ) and Williams, R. J. P. (England) provided important suggestions and advice to the Committee. This volume includes contents of the talks given by the invited speakers and some, but not all of the free communications. The contributions are grouped according to subject and based on the classification made by the editor.
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