Neuropharmacology of Movement Disorders: Comparison of Spontaneous and Drug-Induced Movement Disorders.- I. Parkinson's Disease.- 1. Parkinsonism: Physiology and Pharmacology.- 2. Role of B-Type Monoamine Oxidase Inhibition in the Treatment of Parkinson's Disease: An Update.- 3. Parkinson's Disease: Current Concepts.- 4. The Clinical Evaluation of Drug Therapy in Parkinsonism and Models of Dysfunction of Brain Dopamine Systems in Animals: A Review.- II. Tardive Dyskinesia.- 5. Tardive Dyskinesia: Epidemiology, Pathophysiology, and Pharmacology.- 6. Tardive Dyskinesia and Subtyping of Schizophrenia.- 7. Brain Peptides, Neuroleptic-Induced Tolerance, and Dopamine Receptor Supersensitivity: Implications in Tardive Dyskinesia.- 8. Prevention of Tardive Dyskinesia.- 9. Clinical Aspects of Tardive Dyskinesia; Epidemiology, Natural History, and Management.- 10. Treatments for Tardive Dyskinesia: An Overview of Noncatecholaminergic/Noncholinergic Treatments.- III. Tourette Syndrome and Tic.- 11. Tourette Syndrome.- 12. Clinical Management of Tourette Syndrome with Clonidine.- 13. The Pathogenesis of Tourette Syndrome: A Review of Data and Hypotheses.- IV. Huntington's Disease.- 14. Biochemical and Pharmacological Aspects of Movement Disorders in Huntington's Disease.- 15. The Effects of Neuroleptics on Longevity in Huntington's Disease.- V. Neuroleptic Drugs in the Production of Movement Disorders.- 16. Movement Disorders Induced by Neuroleptic Drugs.- 17. Movement Disorders and Neuroleptic Medication.- 18. Drug-Induced Movement Disorders.- 19. Movement Disorders Induced by Psychotherapeutic Agents: Clinical Features, Pathophysiology, and Management.- 20. Pharmacotherapy of Movement Disorders in Children and Adolescents.
The human nervous system-that most complex organization of energy and matter-has yielded a few glimmers of understanding of its operational me chanics during the last two decades. These have mostly been at the biochemical level of structure and function. Throughout history, as one of the mysteries of nature begins to yield some insights into its function, it has been beneficial to look at it from different points of view. We have developed a volume on movement disorders that is primarily directed toward the biochemical understanding of these disorders and their treatment. Each disorder is presented from several points of view. Although this approach leads to some repetition, it is our aim that the final outcome be a more complete understanding. Much has been written about movement: the beauty of the prima ballerina, the strength of the olympic athlete, and the agility of the surgeon. Seldom do we stop to look beneath the surface-the coordination of muscle groups, the finely tuned balance allowing rapid response in either direction, the individual muscle fibers coordinated to maximize strength and agility, and the nerve fibers connecting muscle with nerve centers. Some of these communicate sensory input of position to the centers while others communicate directions of move ment to muscles. We encourage our readers to be constantly alert to the possibility of in creasing their understanding of other nervous system functions, including thought disorder, through an understanding of movement, either in general principle or by specific chemical interaction.
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