I: Techniques to Study Myocardial Injury.- Propagation Mechanisms in Normal and Injured Myocardium.- The Possibility of Propagation Between Myocardial Cells not Connected by Low-resistance Pathways.- Effects of Injury on the Structure of Intercellular Junctions in Cardiac Muscle.- Modulation of Junctional Permeability in Cardiac Fibers.- The Role of Cell-to-Cell Coupling in Cardiac Conduction Disturbances.- A Model Study of the Effect of the Intercalated Discs on Discontinuous Propagation in Cardiac Muscle.- Adrenergic and Cholinergic Receptors.- Beta-adrenergic Stimulation of Adenylate Cyclase and Alpha-adrenergic Inhibition of Adenylate Cyclase: GTP-binding Proteins as Macromolecular Messengers.- Agonist Regulation of the Muscarinic Cholinergic Receptor in Embryonic Chick Heart.- Development and Regulation of Cardiac Muscarinic Acetylcholine Receptor Number, Function and Guanyl Nucleotide Sensitivity.- Regional Distribution of Choline Acetyltransferase Activity and Multiple Affinity Forms of the Muscarinic Receptor in Heart.- Neurochemical Indices of Autonomic Innervation of Heart in Different Experimental Models of Heart Failure.- Isolated Myocardial Cells and Cell Cultures.- Mechanical and Contractile Properties of Isolated Single Intact Cardiac Cells.- Studies of Substrate Metabolism in Isolated Myocytes.- Ion Movements in Adult Rat Heart Myocytes.- Cardiac Muscle Cell Proliferation and Cell Differentiation In Vivo and In Vitro.- Miscellaneous Methods.- Radionuclide Ventriculography to Evaluate Myocardial Function.- Energy Production and Utilization in Contractile Failure Due to Intracellular Calcium Overload.- Aortic Perfusion Pressure and Protein Synthesis.- The Effect of 5-Hydroxytryptamine and Arterial Blood Withdrawal on Cerebral Microcirculation in the Cat, Arterial Permeability in the Rabbit.- II: Different Types of Myocardial Injury.- Free Radicals and The Pathogenesis of Myocardial Ischemia.- Lipid Peroxidation and Acute Myocardial Ischemia.- Oxygen Radicals and Vascular Damage.- Mediation of Sarcoplasmic Reticulum Disruption in the Ischemic Myocardium: Proposed Mechanism by the Interaction of Hydrogen Ions and Oxygen Free Radicals.- Potential Oxidative Pathways of Catecholamines in the Formation of Lipid Peroxides and Genesis of Heart Disease.- Ischemic Injury.- High Energy Phosphates, Anaerobic Glycolysis, and Irreversibility in Ischemia.- Membrane Damage in Ischemia.- Intercellular Calcium Homeostasis with Extrapolations to Cardiac Ischemia.- Immunologic Insults to the Heart.- The Role of Heart Binding Antibodies in Rheumatic Fever.- Humoral Immunity and Heart Disease: Postpericardiotomy Syndrome.- Cell-mediated Immune Injury to the Heart.- Cellular Immune Mechanisms in Coxsackievirus Group B, Type 3 Induced Myocarditis in BALB/C Mice.- Chemically Induced Toxic Injuries to the Myocardium.- A Molecular Biologic Approach to Cardiac Toxicity.- Anthracycline Cardiotoxicity.- Allylamine Cardiotoxicity: Methabolism and Mechanism.- Cardiovascular Toxicity of Ionophores Used as Feed Additives.- Sensitivity and Resistance of the Myocardium to the Toxicity of Isoproterenol in Rats.- Electrocardiographic Monitoring in Toxicological Studies: Principles and Interpretations.
The chapters of this book represent contributions by plenary lecturers and invited symposium speakers of the Fourth Annual Meet ing of the American Section of the International Society for Heart Research, held on May 26-29, 1982 in New Orleans, Louisiana. The aim of the Organizing Committee was to present an up-to-date picture of our knowledge of myocardial injury which would be equally useful to basic scientists and clinicians. The papers of this volume are divided into two groups: a) those dealing primarily with techniques to study myocardial injury, and b) those that discuss the different types of myocardial lnJury. The grouping of the papers within each of these headings roughly corresponds to the symposia presented at the meeting. I wish to acknowledge the financial support of the National Institutes of Health. Without grant HL 29149, the program could not have been financed. Contributions from the following companies were also gratefully received: Ayerst Laboratories, Ciba-Geigy, Merck Sharp and Dome, Pfizer Laboratories Division, A.H. Robbin Co., Smith-Kline Corporation, U.S.V. Pharmaceutical Co., and The Upjohn Co. My thanks are due to the members of The Organizing Committee (Drs. Gregory J. Bagby, Gerald S. Berenson, Alastair H. Burns, Harvey I. Miller, Robert Roskoski, Jr., and Judy A. Spitzer) for their help and support, and to the Secretary of the Meeting, Ms. L. Beatrice Abene for her excellent assistance. John J. Spitzer, M.D.
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