Session I - Oxygen Measurements in Blood and Tissue.- A Method for Simultaneous Measurements of Bioelectric Activity and Local Tissue PO2 in the CNS.- Oxygen Fields Induced by Recessed and Needle Oxygen Microelectrodes in Homogeneous Media.- The Application of Histological Analysis for the Localization of Tissue PO2 and Local Blood Flow with the Example of the Glomus Caroticum of the Rabbit (Oryctolagus cuniculus).- A Method for Measuring Oxygen Uptake Rate Distributions Over the Surface Zone of Excised Tissues Using a 91-Cathode Electrode.- Monitoring of PO2 in Human Blood.- A New Approach to the Experimental Measurement of Mean Tissue PO2.- Pyrene Butyric Acid: A Non-Invasive Probe for In Situ Intracellular Oxygen Concentration.- Kryomicrophotometry as a Method for Analyzing the Intracapillary HbO2 Saturation of Organs Under Different O2 Supply Conditions.- Quantitative Fluorescence Photometry with Biological Fluids and Gases.- Control of Electrode Aging by a Periodic Anodization Technique.- Session II - Blood Oxygenation.- Effects of 2,3-Diphosphoglycerate on Functional Properties of Hemoglobin and on Glycolysis of Human Erythrocytes.- The Effect of Red Cell 2,3-DPG Changes Induced by Diabetic Ketoacidosis on Parameters of the Oxygen Dissociation Curve in Man.- The Influence of MgCl2 on the O2-Hb-Binding Curve of Human Hemoglobin Under Intracellular Conditions.- Oxygen Transport and Hemodynamics of Stroma-Free Hemoglobin Solutions.- Oxygen Transport on Mount Everest: The Effects of Increased Hematocrit on Maximal O2 Transport.- Measurement of Oxygenation and Deoxygenation of a Single Red Cell of Chicken Embryo by Means of a Microphotometer.- Session III - Tissue Respiration.- Cellular Control of Mitochondrial Respiration.- Influence of Hemoglobin Oxygen Affinity on Oxidation Reduction State of Cytochrome aa3 in Perfused Liver.- Problems in Determination of Oxygen Dissociation of Avian Blood.- Metabolic and Electron Microscopic Studies Post Mortem in Brain Mitochondria.- Early Structural Changes in Mitochondria in Response to Acute Reductions in Capillary Flow.- The Induction of Cytochrome P-450 by Hypoxia.- Session IV - Oxygen Diffusion in Blood and Tissue.- Diffusion of Oxygen in Plasma and Blood.- Facilitated Diffusion of Oxygen in Red Blood Cell Suspensions.- Measurement of Diffusivity and Metabolic Rate of O2 and CO2 in Respiring Tissue.- Facilitated Diffusion of CO and Oxygen in the Presence of Hemoglobin or Myoglobin.- The Measurement of the Fraction of Oxygen Carried by Facilitated Diffusion.- Measurement of Diffusion Parameters with Noble Metal Electrodes.- Session V - Mathematical Models to Describe Oxygen Transport in Blood and Tissue.- A Generalized Advancing Front Model Describing the Oxygen Transfer in Flowing Blood.- A Theoretical Model of the Respiratory Function of Blood.- Some Model Results on Hemoglobin Kinetics and Its Relationship to Oxygen Transport in Blood.- The Mechanical Basis for Fick's Law and Its Generalizations.- A Stochastic Model for the Transport of Oxygen to Brain Tissue.- Models for O2 and CO2 Transfer in Macroscopic Flow Channels and Their Physiological Implications.- Session VI - Oxygen Supply of the Central Nervous System.- Correlation Between the Redox State, Electrical Activity and Blood Flow in Cat Brain Cortex During Hemorrhagic Shock.- Cortical NADH, pO2, Electrical Activity and Arterial Blood Pressure Oscillations in Hypoxaemia.- The Effect of Decapitation on the Oxidation-Reduction State of NADH and ECoG in the Brain of the Awake Rat.- Cerebral Oxygen Supply in Brain Edema and During Ventriculo-Cisternal Perfusion.- Tissue Responses to Hypoxia, Shock and Stroke.- Cerebral Oxygenation in Arterial Hypoxia.- Theoretical and Experimental Aspects of Brain Tissue Oxygenation Dynamics.- Session VII - Oxygen Supply of the Central Nervous System.- Local Tissue PO2 and Microflow of the Brain Cortex Under Varying Arterial Oxygen Pressure.- An Analysis of Ion Distribution in Brain Followi
This volume contains those papers which were presented at the Second International Symposium on Oxygen Transport to Tissue, to gether with the discussions which followed. These discussions were generously summarized by the chairmen of the various sessions. This symposium in Mainz was the third international meeting, after those held in Dortmund in 1971 and Charleston-Clemson in 1973, which dealt primarily with problems relating to oxygen transport to tissue under physiological and pathophysiological conditions. It was the second symposium conducted by the International Society on Oxygen Transport to Tissue which was founded in 1973. We dedicate this volume to the memory of the first president of the International Society on Oxygen Transport to Tissue, Dr. Mel vin H. Knisely. July, 1975 JUrgen Grote Daniel D. Reneau Gerhard Thews Contents Welcome xxi G. Thews Session I - OXYGEN MEASUREMENTS IN BLOOD AND TISSUE A Method for Simultaneous Measurements of Bioelectric Activity and Local Tissue P02 in the CNS . . . . . . . . . . . . 3 A. Lehmenkuhler, H. Caspers, and E. -J. Speckmann Oxygen Fields Induced by Recessed and Needle Oxygen Microelectrodes in Ho- geneous Media . . . . . 9 G. Schneiderman and T. K. Goldstick The Application of Histological Analysis for the Localization of Tissue P02 and Local Blood Flow with the Example of the Glomus Caroticum of the Rabbit (Oryctolagus cuniculus) . . . . . . . . . . . . . . . . . . . 17 H. Weigelt, E. Seidl, H. Acker, and D. W.
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