Bilirubin Chemistry.- An Overview of Bilirubin Chemistry.- The Conjugates of Bilirubin.- Discussion Period R.Schmid, Chariman.- Bilirubin Production.- Bilirubin Metabolism: An Overview.- Bilirubin Production from Non-Erythroid Sources.- Bilirubin Production from Erythroid Sources.- Induction Mechanisms for Bile Pigment Formation.- Carbon Monoxide Production as a Measurement of Heme Catabolism.- Discussion Period R.Lester, Chairman.- Bilirubin Throughput.- Total Body Handling of Bilirubin.- The Hepatic Uptake Process: Its Implications for Bilirubin Transport.- Protein Binding and Conjugation of Bilirubin in the Liver Cell.- Discussion Period H. O. Wheeler, Chairman.- Biliary Secretion.- Principles of Biliary Secretion.- Physiological Considerations in the Planning of Studies of Cholestasis.- Canalicular Anion Transport, Pathogenetic Mechanisms and a Steady State Distributed Model for Measuring Kinetics.- Discussion Period A. Sass-Kortsak, Chairman.- Disorders of Bilirubin Metabolism.- Hemolysis, Jaundice and Liver Disease.- The Functional Basis of Physiologic Jaundice of the Newborn.- Photopharmacology and Bilirubin.- Discussion Period A. Sass-Kortsak, Chairman.- Extrahepatic Biliary Obstruction.- The Future of Endoscopic Retrograde Cholangiopancreatography (ERCP) as a Clinical and Research Tool.- The Advantages of Pre-operative Umbilicoportal Catheterization and Venography in Extrahepatic Biliary Obstruction.- Biliary Excretory Function and Excretory Patterns in Infantile Cryptogenic Cholestasis.- Discussion Period N. B. Javitt Chairman.- Intrahepatic Cholestasis.- Causation and Consequences of Cholestasis: An Overview.- Non-Steroid Drug Induced Cholestasis and Experimental Cholestasis.- Bile Canalicular Structure and Function.- An Ultrastructural Look at Intrahepatic Cholestasis.- Current Status of Cholestasis Induced by Monohydroxy Bile Acids.- Discussion Period J. W. Steiner M. M. Fisher, Chairmen.- Contributors.
Jaundice is much more than a clinical sign of liver disease. It is also a pathophysiological disorder. Through studying it we have come to a much better understanding of how the liver functions under normal and abnormal circumstances. In spite of several important advances in this field, it has not recently been the subject of a comprehensive and interdisciplinary review. This Symposium was held in Montreal on May 31 and June 1, 1974, and the experts who participated in it came together for the purpose of reviewing the current status of Jaundice. The Editors sincerely appreciate the outstanding contribution which these experts made to the Second International Symposium of the Canadian Hepatic Foundation. They are also particularly indebted to Valerie M. Price, Executive Director, Canadian Hepatic Foundation, for her invaluable role in the preparation of this publication. Carl A. Goresky Murray M. Fisher v Contents BILIRUBIN CHEMISTRY An Overview of Bilirubin Chemistry 1 A. F. McDonagh The Conjugates of Bilirubin 19 E. R. Gordon Discussion Period. . . 39 R. Schmid, Char:imm BILIRUBIN PRODUCITON 43 Bilirubin Metabolism: An Overview . . . R. Schmid Bilirubin Production fram Non-Erythroid SoUI"Ces . . . . . . . . . . . . . . . . 57 S. H. Robinson Bilirubin Production fram Erythroid Sources 69 U. Muller-Eberhard and E. F. Johnson Induction Mechanisms for Bile Pigment Formation 85 B. A.
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