This is the proceedings of the International Conference on AIDS Associated Syndromes held at Irvine on December 7-8, 1984. The purpose of this conference was to bring together investigators who are actively engaged in AIDS research to present their most recent data with regard to etiological agent(s) of AIDS, immunological characteristics of some of the patients in early stages of AIDS and various therapeutical modalities that are available for the treatment of AIDS, early AIDS (persistent generalized lymphadnopathy) or for those who demonstrate asymptomatic acquired immunodeficiency. In the area of etiological agents, the discussions are presented dealing with the questions of whether HTLV III/LAV alone or with other co-factor(s) like EBV or CMV are responsible for AIDS. What is the relationship of these viruses to Kaposi's sarcoma, since Kaposi's sarcoma in AIDS cannot be simply explained on the basis of the underlying immune deficiency? Data are presented for HTLV III/LAV interactions with the T4 molecule on the surface of helper T cells. A paper is presented with epidemiologicai evidence for AIDS being an African disease which perhaps was brought to the United States and then to Haiti.
AIDS-An African Disease?.- Etiology of AIDS: Biological and Biochemical Characteristics of HTLV III.- Lymphadenopathy Associated Virus (L.A.V.): Its Association with AIDS or Prodromes.- Expression of HTLV III Infection in a Pediatric Population.- Role of Epstein-Barr Virus in Acquired Immune Deficiency Syndrome.- Longitudinal Immunological Studies on a Cohort of Initially Symptom-Free Homosexual Men in London with Respect to HTLV III Serology.- Lymphadenopathy: End Point or Prodrome? Update of a 36-Month Prospective Study.- The Syndrome of Persistent Generalized Lymphadenopathy: Experience with 101 Patients.- Longitudinal Assessment of Persistent Generalized Lymphadenopathy (PGL) in Homosexual Men.- Cytotoxic Effector Mechanisms in AIDS.- Expression of Beta 2 Microglobulin on the Surface of Mononuclear Cells in Patients with Acquired Immune Deficiency Syndrome (AIDS) and AIDS-Related Complex (ARC) Ill.- Isolated Thrombocytopenia in Homosexual Men-Longitudinal Follow-Up.- Oral Viral Leukoplakia-A New AIDS-Associated Condition.- Thymosin in the Staging and Treatment of HTLV III Positive Homosexuals and Hemophiliacs with AIDS-Related Immune Dysfunction.- The Mechanism and Modulation of Immune Dysfunction in AIDS-Associated Syndromes.- Interferon and Interleukin-2 Therapy of Kaposi's Sarcoma.- Cytotoxic Chemotherapy in Kaposi's Sarcoma.- Conference Summation.- Contributors.
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