Enzymes Metabolizing Phospholipids: From Infancy to Middle Age (Plenary Lecture).- Enzymes of The Metabolism of Fatty Acids and Neutral Glycerides.- Fatty Acid Biosynthesis during Brain Development.- The Role of Soluble Acyl-Thioester Hydrolase in Fatty Acid Chain-Length Termination in Rabbit Mammary Gland and Liver.- Stereochemical Studies of Hydrogen Incorporation from Nucleotides with Fatty Acid Synthetase from Brevibacterium ammoniagenes.- Cholesterol Oxidase as a Probe for Studying Membrane Composition and Organization.- Adsorption and Activation of Pancreatic Lipase at Interfaces.- Mode of Action of Pancreatic Colipase.- Studies of Lipase and Phospholipase A2 Acting on Lipid Monolayers.- Inhibition of Lipase Adsorption at Interfaces Role of Bile Salts Micelles and Colipase.- Lipases of Rat Brain Microsomes.- Identification and Some Characteristics of the Enzyme Protein of the Hormone-Sensitive Lipase from Rat Adipose Tissue.- Affinity Chromatography on Heparin-Sepharose of Rat Adipose Tissue Triglyceride Lipase from Cytosol.- Enzymes of the Metabolism of Glycerophospholipids.- A) Phospholipases.- Relationship between Structure and Activity of Pancreatic Phospholipase A2.- Kinetic Anomalies Associated with Phospholipase A2 Hydrolysis of Micellar Substrates.- Mechanism of Phospholipase A2 Action Towards Mixed Micelles of Detergent and Phospholipids.- Chemical Modification of Crotalus atrox Phospholipase A2 by Means of a Photolabile Phosphatidylethanolamine Analog.- Phospholipases A of Krebs II Ascites Cells: Specificity, Release and Subcellular Localization.- Phospholipases of Plasmic Membranes of Adipose Tissue. Possible Intermediaries for Insulin Action.- Calcium-Activated Hydrolysis of Triphosphoinositide in Synaptosomes.- The Activity of Phospholipase D on Aggregates of Phosphatidylcholine, Dodecylsulfate and Ca2+.- The Preparation of Phospholipids by Phospholipase.- The Effects of Amphiphilic Compounds on Phosphatidate Metabolism.- B) Biosynthesis.- Choline and Ethanolamine Kinase Activity in the Cytoplasm of Nerve Endings from Rat Forebrain.- The Release of Free Ethanolamine in Rat Brain Homogenates Incubated in Krebs Ringer.- Ethanolamine and Choline Phosphotransferases of Chicken Brain.- Studies of Rat Brain Choline Ethanolamine Phosphotransferases Using Labeled Alkylacylglycerol as Substrate with Evidence for Reversibility of the Reactions.- The Role of Phosphatidylglycerol as a Donor of Phosphatidyl and of sn-Glycerol-l-Phosphate Groups in Biosynthetic Reactions.- Membrane-Bound Base-Exchange Reactions in Animal Tissues.- The "Base-Exchange" Reaction: The Serine Enzyme.- A Study on the Possible Occurrence of Base-Exchange Reactions in Vivo.- The Biosynthesis and Hormonal Regulation of Surfactant Formation.- Properties of a Lysophospholipase-Transacylase from Rat Lung: Its Possible Involvement in the Synthesis of Lung Surfactant.- A Study on the Turnover of Rat Brain Phosphatidic Acid through the Glycerol-Phosphate Pathway.- C) Ether Lipids.- Studies on the Biosynthesis of the O-Alkyl Bond in Glycerol Ether Lipids.- Asymmetric Localization of Alkyldihydroxyacetone-P Synthase and Acyldihydroxyacetone-P Acyltransferase in Microsomal Vesicles.- Studies on Soluble Proteins Stimulating Plamalogen Biosynthesis.- Pathway for Hydrolysis of Plasmalogens in Brain.- Turnover of Molecular Species of Diacyl and Alkyl Ether Phospholipids in Ehrlich Ascites Tumor Cells.- Enzymes of the Metabolism of Sphingolipids.- A) Neuraminidases.- Neuraminidase Gangliosides Interactions.- Action of Rat Brain Sialidase on Synaptic Membrane Components in situ.- Interaction of Human Brain Neuraminidase with Tritium-Labelled Gangliosides.- Studies on Bovine Brain Membrane-Bound Neuraminidase (Sialidase).- Intraneuronal Distribution of Cytosoluble Neuraminidase in Pig Brain.- B) Sphingomyelinases.- Effect of Detergents on the Utilization of Sphingomyelin by Brain Sphingomyelinases.- Sphingomyelinase of Human Tissues.- C) Glycolipid Hydrolases
Klappentext
This book presents the proceedings of the meeting on "Enzymes of Lipid Metabolism" which took place April 18-22, 1977, at the Mont Ste. Odile convent in Alsace, France. The meeting was convened and co-ehaired by P. Mandel and S. Gatt. L. Freysz was general seeretary. They were assisted by an international advisory commit tee and a loeal organizing committee. The purpose of the meeting was to bring together scientists involved in research on a wide variety of aspeets of lipid metabo lism and who have a direct interest in the problematies on inter acting enzymes with lipid substrates. The aim was to emphasize the latter aspect rather than common enzymologieal aspects such as extraetion, purification, and protein strueture. The rpeoeedings included several symposia and four "round-table" discussions. There was also a presentation of posters, whieh were exhibited during the entire duration of the meeting. All partieipants who presented leetures or posters were requested to summarize their findings, whieh were ineluded in the book. Regretfully, the very fruitful discus sions of the "round-tables" were not included, nor were those held in the informal atmosphere of the court yards of the eonvent, the hiking paths in the Vosges mountains, and the bar. For the purpose of coherence, the editors decided not to adhere to the original order of the lectures. The papers in the book are grouped ae eording to the classes of enzymes and the types of reaction which they catalyze.
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