Preface.- Section 1: Cell Biology.- Stem Cells in the Normal and Malignant Prostate.- Role of Reactive Stroma in Prostate Cancer.- The Role of Cholesterol in Prostate Cancer.- Section 2: Genetics: PTEN in Prostate Cancer.- ETS fusion genes in prostate cancer.- Section 3: Cell Signaling.- Signaling Mechanisms of Vav3, a Guanine Nucleotide Exchange Factor and Androgen Receptor Coactivator, in Physiology and Prostate Cancer Progression.- Transforming Growth Factor-beta (TGF-b) in Prostate Cancer.- The p38 MAPK Pathway in Prostate Cancer.- NF-kappaB2/p52 in Prostate Cancer.- The functional role of DAB2IP, a homeostatic factor, in prostate cancer.- Tyrosine Kinases in Prostate Cancer.- Human prostatic acid phosphatase in prostate carcinogenesis.- Section 4: Hormonal.- Truncated Androgen Receptor Splice Variants in Prostate Cancer.- Biology and Clinical Relevance of Estrogen Receptors in Prostate Cancer.- Vitamin D and Prostate Cancer.- HDAC6 regulation of androgen signaling in prostate cancer.- Beyond the cell cycle: Implications of D-type cyclin deregulation in Pca.- Section 5: Cell Death.- Role of Par- in Prostate Cancer.- Autophagy and Prostate Cancer Therapeutics.- Index.
Prostate Cancer provides an up-to-date review of the biochemistry, molecular biology, and genetic changes in prostate cells that are the driving forces in the initiation and progression of cancer. It includes an overview by experts in the field of cell-cell interactions, including stem cells, reactive Stromal cells and membrane lipid rafts that are instrumental in the initiation and progression of prostate cancer.
Gives the reader a comprehensive conceptual framework of the cellular mechanism that are critical for the initiation and progression of prostate cancer
Geared toward basic scientists, instead of largely clinically oriented
Includes an overview by experts in the field of cell-cell interactions, including stem cells, reactive Stromal cells, and membrane lipid rafts that are instrumental in the initiation and progression of prostate cancer