Über den Autor
Please see attached CV for details.
The volume editor has received millions of dollars in grants from the NIH and NCI for projects on prostate cancer stem cells.
Preface.- Stem Cells and Prostate Development.- Isolation and Characterization of Prostate Stem Cells.- Prostate tumor initiating cells.- TIC Markers and methods of characterization.- Genetic Control of Self Renewal of the TIC.- Therapeutic targeting of the prostate TIC.- The prostate stem cell niche.- Tumor stroma control of the prostate TIC.- Targeting the prostate stem cell for chemoprevention.- Stem cell models for functional validation of prostate cancer genes.- Index¿.
¿¿¿¿Recent evidence demonstrates that normal prostate tissue contains stem cells. There is also accumulating evidence that prostate cancer contains a population of cells with stem cell-like characteristics referred to as cancer stem cells, or tumor initiating cells. Both the normal prostate stem cell and cancer stem cell populations have important implications for the generation, therapeutic targeting, and prevention of prostate cancer. The purpose of this book is to explore the role of stem cells in prostate cancer, which is becoming an increasingly hot trend in cancer research. ¿
Explores the role of the stem cell in prostate cancer research
Discusses the role of the prostate cancer microenvironment in the regulation of the stem cell niche
Examines the use of stem cells to model prostate cancer genetics