Foreword.- Modeling Mycobacterium tuberculosis H37Rv in silico.- Software Platform for Metabolic Network Reconstruction of Mycobacterium tuberculosis.- Probing Gene Regulatory Networks to Decipher Host-Pathogen Interactions.- Metabolism of Mycobacterium tuberculosis.- Protein-protein interaction in the -omics era: Understanding Mycobacterium tuberculosis function.- A systems biology approach for understanding granuloma formation and function in tuberculosis.- Stochastic gene expression in bacterial pathogens: a mechanism for persistence?.- Drug Discovery.- Diagnosis.- Index.
The book starts with a general introduction into the relevance of systems biology for understanding tuberculosis. This will be followed by several chapters which describe the application of systems biology to various aspects of the study of the pathogen, Mycobacterium tuberculosis, and its interaction with the host. The book provides the reader with an account of how the new science of systems biology is providing novel insights into the ancient scourge of tuberculosis. It will also describe how systems biology can be applied to the control of tuberculosis, including the development of new treatments, vaccines and diagnostics.