Introduction to germ cell development in C. elegans.- Germ cell specification.- Sex determination in the C. elegans germline.- Stem cell proliferation versus meiotic fate decision in C. elegans.- Physiological control of germline development.- Meiotic development in C. elegans.- Spermatogenesis.- Translational control in the C. elegans germ line.- Germ cell apoptosis and DNA damage responses.- Control of Oocyte Growth and Meiotic Maturation in C. elegans.- Fertilization.- The oocyte-to-embryo transition.- Epigenetic Control of Germline Development.- Using Caenorhabditis to explore the evolution of the germ line.- Index.
Germ cells in sexually reproducing metazoa, through the germline lineage, are the route by which genetic material and cytoplasmic constituents are passed from one generation to the next in the continuum of life. Chapters in this book review germ cell development in the model organism Caenorhabditis elegans, discussing the biology, the genetics and the molecular mechanisms for various processes, as well as drawing comparisons with other organisms. Processes discussed include specification of germ cell fate, meiosis, gametogenesis, environmental/ physiological controls, epigenetics and translational control, fertilization and the oocyte-to-embryo transition. This book thus provides a comprehensive picture of the germline lineage and the continuum of life for the worm.
This book will cover all aspects of C. elegans germ cell development
A distinct perspective will be given through a large range of authors
The audience for this book are researchers in the field and advanced graduate students working on specific chapter areas