Chapter 1, Isoprenoid ModificationsnUyen T.T. Nguyen, Andrew Goodall, Kirill Alexandrov, and Daniel AbankwannChapter 2, GPI-Anchored Proteins in Health and DiseasenDavid R. Taylor and Nigel HoopernnChapter 3, Protein OxidationnC. Quiney, S. Finnegan, G. Groeger, and Tom G. CotternnChapter 4, Involvement of S-Nitrosylation in NeurodegenerationnYihang Li and Kenny K. K. ChungnnChapter 5, Protein Glycosylation, and Congenital Disorders of GlycosylationnEva Morava, Dirk J. Lefeber, and Ron A. WeversnnChapter 6, Defective Glycosylation of Dystroglycan in Muscular Dystrophy and CancernFederica Montanaro and Paul T. MartinnnChapter 7, Protein kinase A: The Enzyme and Cyclic AMP SignalingnMaria Nesterova and Constantine A. StratakisnnChapter 8, The Protein Kinase C Family: Key Regulators Bridging Signaling Pathways in Skin and Tumor EpithelianDirk Breitkreutz, Liora Braiman-Wiksman, Nicole Daum, and Tamar TennebaumnnChapter 9, Maintaining Energy Balance in Health and Disease: Role of AMP-activated Protein KinasenJohn W. ScottnnChapter 10, Protein Phosphatases in the Brain: Regulation, Function and DiseasenRy Y. Tweedie-Cullen, C. Sehwan Park, and Isabelle M. MansuynnChapter 11, Covalent Protein Modification as a Mechanism for Dynamic Recruitment of Specific InteractorsnNicholas R. Bertos, Veena Sangwan, Xiang-Jiao Yang, Morag ParknnChapter 12, Regulation of Gene Expression by the Ubiquitin-Proteasome System and Implications for Neurological DiseasenLisa Lukaesko and Robert MellernnChapter 13, Small Ubiquitin-like Modifiers and other Ubiquitin-like ProteinsnMartijn van Hagen and Alfred VertegaalnnChapter 14, ER-associated Degradation and its Involvement in Human Disease: Insights from YeastnNathalie Campagnolo and Michel GhislainnnChapter 15, Regulation of Chromatin Structure and Transcription via Histone ModificationsnKajan Ratnakumar, Avnish Kapoor, and Emily BernsteinnnChapter 16, Chromatin: the Entry to and Exit from DNA RepairnAnastas Gospodinov and Zdenko Herceg nnChapter 17, Poly(ADP-rybosyl)ation of Chromosomal Proteins: Epigenetic Regulation and Human Genomic Integrity in Health and DiseasenRafael Alvarez-GonzaleznnChapter 18, Post-translational Proteolytic Processing on Intracellular Proteins by Cathepsins and CystatinsnNobuhiko Katunuma, Masae Takahashi, and Tadashi TezukannChapter 19, Metalloproteases and Proteolytic ProcessingnAnthony J. Turner and Natalia N. Nalivaeva
Post-translational modifications serve many different purposes in several cellular processes such as gene expression, protein folding and transport to appropriate cell compartment, protein-lipid and protein-protein interactions, enzyme regulation, signal transduction, cell proliferation and differentiation, protein stability, recycling and degradation. Although several-hundred different modifications are known, the significance of many of them remains unknown. The enormous versatility of the modifications which frequently alter the physico-chemical properties of the respective proteins represents an extraordinary challenge in understanding their physiological role. Since essential cellular functions are regulated by protein modifications, an improvement of current understanding of their meaning might allow new avenues to prevent and/or alleviate human and animal diseases.
1. Over 40 color figures
2. Contains 19 updated reviews that stimulate further investigations in the proteomic field
3. Improves current understanding of protein modifications, allowing new avenues to prevent and/or alleviate human and animal diseases