Über den Autor
Dr. Vassilis Cutsuridis is a Research Fellow in the Department of Computing Science and Mathematics at the University of Stirling, Scotland, UK.Bruce P. Graham is a Reader in Computing Science in the Department of Computing Science and Mathematics at the University of Stirling.Stuart Cobb is a Senior Lecturer in the Neuroscience and Molecular Pharmacology Department at the University of Glasgow, Scotland, UK.Imre Vida is a Senior Lecturer in the Neuroscience and Molecular Pharmacology Department at the University of Glasgow.
PrefacenPart In1. Introduction-Experimental backgroundn2. Connectivity of the hippocampusn3. Cell morphologies n4. Physiological properties of hippocampal neurons n5. Glutamatergic neurotransmission in the hippocampus n6. Fast and slow GABAergic transmission in hippocampal circuitsn7. Synaptic plasticity at hippocampal synapses n8. Neuromodulation of hippocampal cells and circuits n9. Neuronal Activity Patterns during Hippocampal Network Oscillations in Vitro n10. Neuronal Activity Patterns of Anaesthetized Animalsn11. Spatial and behavioral correlates of hippocampal neuronal activity: A primer for computational analysisnPart IIn12. Introduction-Computational Analysisn13. The making of a detailed CA1 pyramidal neuron modeln14. CA3 cells: Detailed and simplified pyramidal cell modelsn15. Entorhinal cortex cellsn16. Single Neuron Models: Interneuronsn17. Gamma and Theta Rhythms in Biophysical Models of Hippocampal Circuitsn18. Associative memory modelsn19. Microcircuit model of the dentate gyrus in epilepsyn20. Multi-level modelsn21. Biophysics-based models of LTP/LTDn22. A phenomenological calcium-based model of STDPn23. Computer simulation environments
Rich in detail, Hippocampal Microcircuits: A Computational Modeler's Resource Book provides succinct and focused reviews of experimental results. It is an unparalleled resource of data and methodology that will be invaluable to anyone wishing to develop computational models of the microcircuits of the hippocampus. The editors have divided the material into two thematic areas. Covering the subject's experimental background, leading neuroscientists discuss the morphological, physiological and molecular characteristics as well as the connectivity and synaptic properties of the various cell types found in the hippocampus. Here, ensemble activity, related to behavior, on the part of morphologically identified neurons in anesthetized and freely moving animals, lead to insights into the functions of hippocampal areas. In the second section, on computational analysis, computational neuroscientists present models of hippocampal microcircuits at various levels of detail, including single-cell and network levels. A full chapter is devoted to the single-neuron and network simulation environments currently used by computational neuroscientists in developing their models.
In addition to the above, the chapters also identify outstanding questions and areas in need of further clarification that will guide future research by computational neuroscientists.
Microcircuits, excitatory, inhibitory, hippocampus