INTRODUCTION.- What are the machines in the life cycle of a virus?.-MOLECULAR MACHINES.- Beef F0 proton pump ATPase.- Flagella.- VIRUS ARCHETECTURE AND STRUCTURE.- Principles.-METHODS OF VIRAL ENTRY.- Polioviruses.- Alphaviruses.- Fusion type 1.- Flu.- HIV.- corona.- Fusion type 2.- Function of the tails for bacteriophages.- contractile (Petr Leiman.- non-contractile-long.- non-contractile-short.- GENOME REPLICATION.- Bunyaviruses.- Reoviruses.- DNA dependent, RNA dependent DNA and RNA polymerases.- CAPSID ASSEMBLY AND MATURATION.- Protein folding: chaperones.- Scaffolding proteins.- pH, proteolysis, metal ions, temperature as driving forces for assembly.- HK97 head maturation.- PRD1 assembly.- Herpes.- Adenovirus.- Large dsDNA viruses.- GENOME PACKAGING.- genome organization.- dsRNA viruses.- dsDNA packaging.- phi29 DNA packaging.- RNA packaging.- helical viruses.-
Viruses: Sophistiated Biological Machines.- F1-Atpase: A Prototypical Molecular Motor.- Reconstructing Virus Structures From Nanometer To Near-Atomic Resolutions With Cryo-Electron Microscropy And Tomography.- Principles Of Virus Structural Organization.- Viral Entry Machines.- Genome Replication Machines.- Capsid Assembly And Maturation.- Genome Packaging Machines.
This book will contain a series of solicited chapters that concern with the molecular machines required by viruses to perform various essential functions of virus life cycle. The first three chapters (Introduction, Molecular Machines and Virus Architecture) introduce the reader to the best known molecular machines and to the structure of viruses. The remainder of the book will examine in detail various stages of the viral life cycle. Beginning with the viral entry into a host cell, the book takes the reader through replication of the genome, synthesis and assembly of viral structural components, genome packaging and maturation into an infectious virion.
Each chapter will describe the components of the respective machine in molecular or atomic detail, genetic and biochemical analyses, and mechanism. Topics are carefully selected so that the reader is exposed to systems where there is a substantial infusion of new knowledge in recent years, which greatly elevated the fundamental mechanistic understanding of the respective molecular machine. The authors will be encouraged to simplify the detailed knowledge to basic concepts, include provocative new ideas, as well as design colorful graphics, thus making the cutting-edge information accessible to broad audience.
Written by leaders in their respective fields
Uses the best examples from bacteriophages and animal viruses, many causing infectious diseases of public health importance
Conveys state of the art knowledge of the topic generated by combining X-ray crystallography, high resolution electron microscopy, molecular genetics, biochemistry, and single molecule biophysics