Introduction to Network Biology.- Topological Characteristics of Molecular Networks.- Functional Annotation in Gene Networks.- Proteome Network Emulating Models.- Biological Network Alignment.- Pattern Mining across many Massive Biological Networks.- Molecular Networks and Complex Diseases.- Moving Towards Genome-Scale Kinetic Models: The Mass Action Stoichiometric Simulation Approach.- Index.
Molecular networks provide descriptions of the organization of various biological processes, including cellular signaling, metabolism, and genetic regulation. Knowledge on molecular networks is commonly used for systems level analysis of biological function; research and method development in this area has grown tremendously in the past few years. This book will provide a detailed review of existing knowledge on the functional characterization of biological networks. In 15 chapters authored by an international group of prolific systems biology and bioinformatics researchers, it will organize, conceptualize, and summarize the existing core of research results and computational methods on understanding biological function from a network perspective.
Intersects broad sub-disciplines within biology, statistics and computer sciences
Motivates a number of open problems, which provide excellent avenues for continuing efforts in the area
Focuses on the computational challenges associated with systems-level modeling of biological function