1. Pressure induced and metabolic alterations in the glomerulus: Role in cytokine activity and progressive sclerosis.- 2. Definition of diabetic renal disease in insulin-dependent diabetes mellitus based on renal function tests.- 3. Retinopathy in relation to albuminuria and blood pressure in IDDM.- 4. Microalbuminuria and cardiovascular disease.- 5. The heart in diabetes: results of trials.- 6. Albuminuria in non-insulin-dependent diabetes - renal or "extra" renal disease?.- 7. The clinical course of renal disease in Caucasian NIDDM-patients.- 8. Serum creatinine and other measures of GFR in diabetes.- 9. Familial factors in diabetic nephropathy.- 10. Genetics and diabetic nephropathy.- 11. Birth, Barker and Brenner: The concept of low birth weight and renal disease.- 12. Effect of insulin on the kidney and the cardiovascular system.- 13 Value of screening for microalbuminuria in people with diabetes as well as in the general population.- 14. Incidence of nephropathy in IDDM as related to mortality. Cost and benefits of early intervention..- 15. Dysfunction of the vascular endothelium and the development of renal and vascular complications in diabetes.- 16. Urinary tract infections in patients with diabetes mellitus.- 17. Light microscopy of diabetic glomerulopathy: the classic lesions.- 18. Renal structural changes in patients with type 1 diabetes and microalbuminuria.- 19. Renal structure in type 2 diabetic patients with microalbuminuria.- 20. Nephropathy in NIDDM patients, predictors of outcome.- 21. Advanced glycation end-products and diabetic renal disease.- 22. Protein kinase C in diabetic renal involvement, the perspective of inhibition.- 23. Biochemical aspects of diabetic nephropathy.- 24. Pathogenesis of diabetic glomerulopathy: the role of glomerular hemodynamic factors.- 25. An update on the role of growth factors in the development of diabetic kidney disease.- 26. Transforming growth factor-? and other cytokines in experimental and human diabetic nephropathy.- 27. Blood pressure elevation in diabetes: the results from 24-h ambulatory blood pressure recordings.- 28. Microalbuminuria in young patients with type 1 diabetes.- 29. Early renal hyperfunction and hypertrophy in IDDM patients including comments on early intervention.- 30. Diabetes, hypertension, and kidney disease in the Pima Indians.- 31. Autoregulation of glomerular filtration rate in patients with diabetes.- 32. ACE-inhibition, angiotensin II receptor blockade, and diabetic nephropathy.- 33. The concept of incipient diabetic nephropathy and effect of early antihypertensive intervention.- 34. Reversibility of diabetic nephropathy lesions: A new concept.- 35. Antihypertensive treatment in NIDDM, with special reference to abnormal albuminuria..- 36. The course of incipient and overt diabetic nephropathy: the perspective of more optimal treatment, including UKPDS-perspective.- 37. Non-glycaemic intervention in diabetic nephropathy: the role of dietary protein intake.- 38. Diabetic nephropathy and pregnancy.- 39. Evolution worldwide of renal replacement therapy in diabetes.- 40. Haemodialysis and CAPD in type 1 and type 2 diabetic patients with endstage renal failure.- 41. Renal transplantation for diabetic nephropathy.- 42. Combination therapy for hypertension and renal disease in diabetes.- 43. Microalbuminuria in essential hypertension. Significance for the cardiovascular and renal systems.- 44. A comparison of progression in diabetic and non-diabetic renal disease: similarity of progression promoters.- 45. Update of the latest intervention trials in hypertension and type 2 diabetes.- 46. Scientific basis for the new guidelines for the treatment of hypertension in type 2 diabetes.- 47. Regulatory considerations in the development of therapies for diabetic nephropathy and related conditions.- 48. The renin angiotensin system in the pathogenesis of diabetic complications.- 49. Microalbuminuria, blood pressure and diabetic renal disease: Origin and development of ideas.
Few complications of systemic diseases are better understood than diabetic nephropathy. In large part, progress in this area is due to Carl Erik Mogensen's steadfast preoccupation over more than three decades with the disorder's epidemiology, pathogenesis, pathophysiology, clinical diagnosis and evolving strategies of management. Though he sparked progress in each of these areas, he generously opens the forum of discussion to many expert contributors to this latest and most comprehensive edition of this exemplary textbook. In eliciting all relevant and up-to-date views, the reader, whether internist, pediatrician or specialist in endocrinology or nephrology, is assured a thorough review of the entire subject and in a format which is exceptionally well-written, well-illustrated and easy to read.
Each of the prior editions have been an essential resource for my own work in this field and the 5th edition will no doubt continue to provide the information I and others will require to move forward in the years ahead. If only the other renal diseases were as masterfully synthesized, how much easier our task would be of achieving a comprehensive vision of all else in clinical nephrology.
Barry M. Brenner, M.D., Samuel A. Levine Professor of Medicine, Harvard Medical School
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