Can the physician predict the neuropathologist? M.N. Rossor. The Molecular Parameters of Tau Pathology, Tau as a killer and a witness; A. Delacourte . Tau Gene Mutations and Tau Pathology in Frontotemporal Dementia and Parkinsonism Linked to Chromosome 17; M.G. Spillantini, M. Goedert . Argyrophilic Grain Disease, a Frequent Dementing Disorder in Aged Patients; M. Tolnay, et al. Tau Pathology in Neurons and Glial Cells of Aged Baboons; C. Schultz, et al. Human Tau Transgenic Mice, Towards an animal model for neuro- and glialfibrillary lesion formation; E. Götz, et al. Regulation of Alzheimer beta-Amyloid Precursor Trafficking and Metabolism; S. Gandy, S. Petanceska . Role of Type 10 17beta-Hydroxysteroid Dehydrogenase In the Pathogenesis of Alzheimer's Disease; Song-Yu Yang, Xue-Ying He. The Spectrum of Vascular Disease in Dementia, From ischemia to amyloid angiopathy; R.O. Weller, S.D. Preston. Transgenic Mouse Models of Cerebral Amyloid Angiopathy; M.C. Herzig, et al. Alpha-Synuclein, Axonal transport, ligand interaction and neurodegeneration; P. Henning Jensen, Wei Ping Gai . Dementia with Lewy Bodies; P. Ince. Mouse Models of alpha-Synucleinopathy and Lewy Pathology, alpha-synuclein expression in transgenic mice; S. Barbieri, et al. Ubiquitin and the Molecular Pathology of Neurodegenerative Diseases; J. Lowe, et al. Perisomatic Granules Of Hippocampal CA1 Neurons in Alzheimer's disease, pre-Alzheimer Stage and Pick's Disease: An Overlooked Pathological Entity; A. Probst, et al. Pathological Mechanisms in Polyglutamine Expansion Diseases; D. Devys, et al. Dementia in the Neuronal Ceroid-Lipofuscinoses; H.H. Goebel, A. Kohlschütter. Neurodegeneration-Associated Proteins and Inflammation in Sporadic Inclusion-Body Myositis; J.B. Lampe, et al. MitochondrialDysfunction in Neurodegenerative Disorders and Ageing; C. Turner, A.H.V. Schapira. Index.
these "tauopathies" are reviewed by Delacourte. Therecentdiscoverythatmutationsofthetaugenearecausativeforfamilial formsoffrontotemporaldementiaandParkinsonism(FTDP-17)broughtthe "taupathway"and the"tauopathies"tothecentrestage.Thisextraordinary breakthroughwillbecoveredbySpillantiniandGoedert.Thereisincreasing evidence that argyrophilic grain disease is much more frequent in older patients than previously thought. Tolnay et al. are reviewing recent contributionstothepathologyofthislate-onsetdementingdisorderinwhich ofamyloidbetadeposits,isalmost taupathology,inthealmosttotalabsence exclusivelyrestricted to the limbic lobe and the amygdala. Schultzet al. report an intriguing age-related progression of neuronal and glial tau pathologyinbaboonsthusrenderingthe baboonapotentialprimatemodel forage-relatedhuman"tauopathies". Gotzetal. introducetransgenicmice expressingmutated human tau as valuable animal models for reproducing formationofneuro-andglialfibrillarylesions.
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