Preface. Basic Mechanisms. Delineation of the Pathogenesis of Systemic Lupus Erythematosus by Using Murine Models; K. Liu, E.K. Wakeland. Factors Contributing to Autoimmune Disease; K.M. Garza, et al. Control of Autoimmunity by Regulatory T Cells; E.M. Shevach, et al. Autoimmunity, Self-Tolerance, and Immune Homeostasis: From Whole Animal Phenotypes to Molecular Pathways; C.C. Goodnow, et al. Peripheral Tolerance and Organ Specific Autoimmunity; H. von Boehmer, E. Jaeckel. Autoimmune Lymphoproliferative Syndrome: Types I, II, and Beyond; H.J. Chun, M.J. Lenardo. Pathogenesis. The Role of MHC Class II Molecules in the Pathogenesis and Prevention of Type I Diabetes; H. McDevitt. Control of Autoreactive T Cell Activation by Immunoregulatory T Cells; J.-F. Bach. Immune Tolerance and The Nervous System; D.E. Anderson, D.A. Hafler. Functional Role of Epitope Spreading in the Chronic Pathogenesis of Autoimmune and Virus-Induced Demyelinating Diseases; S.D. Miller, T.N. Eager. Therapy. Multiple Sclerosis and Gene Expression Profiling; L. Steinman. Treatment of Autoimmunity by Inhibition of T Cell Costimulation; D.I. Daikh, D. Wofsy. Cytokine Blockade in Rheumatoid Arthritis; M. Feldmann, et al. Index.
Advances in biochemistry, cell biology, genome-wide mutagenesis - coupled with molecular technology, including gene microarray and transgenic and knock-out animals - have been instrumental in understanding the cellular processes and molecular pathways of self-tolerance and autoimmune diseases. The molecular definition of these pathways and processes has led to novel treatments for certain auto-immune diseases that are based on the pathogenesis of diseases rather than on broad-spectrum immunosuppression. This book reviews many of these current developments and proposes future novel approaches for understanding the pathogenesis of auto-immune diseases and designing novel therapy. This book covers three major areas of auto-immunity: the basic mechanisms of immunological tolerance, pathogenesis of auto-immune diseases, and some novel therapies.
This book should be useful for immunologists, molecular biologists, rheumatologists, and clinical scientists.
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