Lymphocyte Development and Lymphocyte Traffic. 1. Lymphocyte Development in Neonatal and Adult C-KIT-Deficient (C-KITw/w) Mice; C. Waskow, H.-R. Rodewald. 2. Development of Antigen-Specific Helper T Cell Responses in Vivo; L. McHeyzer-Williams, et al. 3. BCL-6 Uncouples B Lymphocyte Proliferation from Differentiation; D.T. Fearon, et al. 4. The Role of VAV Proteins in B Cell Responses; M. Turner. 5. Traffic Patterns of B Cells and Plasma Cells; J.G. Cyster, et al. 6. Lymphocyte Traffic in Lymphoid Organ Neogenesis Differential Roles of LTalpha and LTalphabeta; D.L. Drayton, et al. 7. Regulation of Spleen White Pulp Structure and Function by Lymphotoxin; D.D. Chaplin. 8. Enzymatic Control of Leukocyte Trafficking Role of VAP-1; M. Salmi, S. Jalkanen. 9. Homeostatic Chemokines and the Targeting of Regional Immunity; E.J. Kunkel, E. Butcher. Naïve and Memory T Cells. 10. Factors Regulating Naïve T Cells Homeostasis; C.D. Surh, et al. 11. IL-7, The Thymus, and Naïve T Cells; Y. Okamoto, et al. 12. Neonates Support "Homeostatic" Proliferation; B. Min, et al. 13. Self-Recognition and the Regulation of CD4+ T Cell Survival; R.N. Germain, et al. 14. TCR-Independent Proliferation and Differentiation of Human CD44 Cell Subsets Induced by Cytokines; J. Geginat, et al. 15. Regulation of Memory CD4 T Cells: Generation, Localization and Persistence; S.L. Swain, et al. 16. Some Properties of T Cells in Animals; A.R. de Souza, et al. 17. Generation and Characterization of Memory CD4 T Cells; S.Z. Ben-Sasson, et al. 18. T Cell Proliferation, Differentiation, and Restoration in Lymphopenic Individuals; J. Chen, et al. 19. Migration of Primary and Memory CD8 T Cells; L. Lefrançois, et al. 20. Cytokines and Memory-Phenotype CD8+ Cells; J. Sprent, et al. 21. Antiviral Memory T Cell Responses: Correlation With Protective Immunity and Implication for Vaccine Development; A. Harari, et al. 22. Homeostatic Proliferation but not the Generation of Virus Specific Memory CD8 T Cells is Impaired in the Absence of IL-15 or IL-15R&agr;; E.J. Wherry, et al. Tracking Immune Cells. 23. Irreversible Marking of Dendritic Cells in Vivo; S. Garg, et al. 24. Tracking Arterial Smooth Muscle Specific T Cells in the Inflamed Vasculature; B. Ludewig. 25. Regulation of T Cell Migration through Formation of Immunological Synapses: the Stop Signal Hypothesis; M. Dustin. 26. Two-Photon Imaging in Intact Lymphoid Tissue; S.H. Wei, et al. Index.
This volume is divided into three sections. Section I deals with factors that regulate the development and maturation of T cells and B cells and lymphocyte traffic. The significance of C-kit, Bcl-6, IL-7, and Vav in the development of T and B lymphocytes is discussed. A role of lymphotoxins and VAP-I in trafficking of leucocytes is reviewed. Finally, the trafficking and homing characteristics of T cell and B cell subsets, and the regulation of these processes during the immune response, is presented.
Section II discusses various aspects of naive and memory T cell biology, including clonal expansion, reprogramming of genes including those encoding cytokines and cytotoxic granules, changes in the expression of cell surface proteins involved in cell-cell adhesion, homing of naive and memory T cells, the role of MHC and cytokines in the maintenance of naive and memory T cells, and the characterization and differentiation of virus-specific memory T cell heterogeneity in mice and humans.
Novel methods of visualization of immune cells and immune systems are reviewed in Section III.
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