An Overview of Heme Oxygenase; N.G. Abraham. Section I: Physiology/Pathology of Heme Oxygenase and its Products, Carbon Monoxide and Bilirubin. I. Development of Heme Oxygenase Inhibitors for the Prevention of Severe Jaundice in Infants: Studies from Laboratory Bench to New Nursery; A. Kappas. 2. Carbon Monoxide: A Potential Anti-inflammatory Agent and Mediator of Lung Anti-Oxidant Defenses; S.W. Ryter, et al. 3. Correlation of the Altered Vascular Effects of Carbon Monoxide and the Cardiovascular Complications of Diabetes; Rui Wang, et al. 4. Endogenous Carbon Monoxide Has Protective Roles in Neointimal Development Elicited by Arterial Injury; T. Morita, et al. 5. End Tidal Breath Carbon Monoxide (ETCO) Levels in Pregnant Women; D.S. Seidman, et al. 6. The Role of Heme Oxygenase in Pregnancy; P. Hewett, A. Ahmed. 7. Increased Carbon Monoxide in Exhaled Air in Patients with Inflammatory Respiratory Diseases; M. Yamaya, et al. 8. Carbon Monoxide and Iron, by-Products of Heme Oxygenase, Modulate Vascular Endothelial Growth Factor Synthesis in Vascular Smooth Muscle Cells; J. Dulak, et al. Section II: Physiological Function of Heme Oxygenase and the Central Nervous System. 9. CO and Neonatal Cerebral Circulation; C.W. Leffler, et al. 10. Differential Expression of Heme Oxygenase-1 in Rat Brain by Endotoxin (LPS); G. Scapagnini, et al. 11. Role of Heme Catabolism in Neurodegenerative Diseases; A. Takeda, et al. 12. Heme Oxygenase-1 and Alzheimer Disease; Y. Mawal, et al. 13. Early Molecular Mechanisms for the Induction of Neuronal Membrane Asymmetry and Genomic DNA Cleavage; K. Maiese, et al. 14. Heme Oxygenase (HO)-1 Expressing Macrophages/Microglial Cells Accumulate During Oligodendroglioma Progression; M.H. Deininger, et al. Section III: Clinical Implications of Heme Oxygenase System in Inflammation. 15. Heme Oxygenase and Ocular Surface Inflammation; M.W. Dunn, M. Laniado-Schwartzman. 16. Targeted Expression of Heme Oxygenase-1 and Pulmonary Responses to Hypoxia; S. Kourembanas, et al. 17. Heme Oxygenase in Skeletal Muscle: Role in Septic Diaphragmatic Failure; C. Taille, et al. 18. Heme Oxygenase-1 (HO-1): Multiple Effects of a Protective Gene That Prevents Graft Rejection; P.O. Berberat, et al. 19. Thioredoxin Facilitates The Induction of Heme Oxygenase-1 in Response to Inflammatory Mediators; M.A. Perrella, Shaw-Fang Yet. Section IV: Heme Oxygenase and Cardiovascular System. 20. Induction of Heme Oxygenase-1 as a Protective Response Against Heme Protein-Induced Renal Injury; K. Nath. 21. Regulation and Role of Heme Oxygenase-1 in Glomerulonephritis; P.K. Datta, E.A. Lianos. 22. Heme Oxygenase-1 Mediates Atrial Natriuretic Peptide Induced Protection of Renal Cells From Cyclosporin Toxicity; T. Polte, et al. 23. Heme Oxygenase and Atherosclerosis; J. Araujo, et al. 24. Atherogenicity of Hypercholesterolemia in the Presence of Hemolysis in Spite of Heme Oxygenase-1 Induction: A Possible Consequence of its Interaction with Plasma Lipoproteins; G. Camejo, et al. 25. Anti-Atherogenic Properties of Heme Oxygenase; K. Ishikawa. 26. Heme Oxygenase and the Novel Tumour-Specific Anti-Vascular Com
Heme oxygenase is rapidly taking its place as the centerpiece of multiple inter acting metabolic systems. Only 25 years ago heme oxygenase and its metabolic prod ucts appeared to be merely a simple metabolic system-one substrate, heme; one enzyme, heme oxygenase; and one set of products, iron to be recycled, and bilirubin and carbon monoxide to be disposed. From a group of about 25 people in 1974, as judged by attendance at various Gordon conferences, heme oxygenase has, in the year 2000, attracted working scientists-and clinicians I might add-by the hundreds and has produced referenced publications by the thousands. It is well-deserved attention. Heme oxygenase system is now similar to the metabolic networks surrounding glucose in those complex maps of glycolytic and non-glycolytic metabolic pathways, which we had to memorize as students. The relevance of heme oxygenase to regulatory biology was recognized many years ago, but the work conducted over the past five years has created a new wave of emphasis focusing on genetic manipulation to alter heme oxygenase gene expression, the regulatory actions of heme oxygenase products including carbon monoxide, and the significance of changes in the heme oxygenase system. The physiological and pathological relevance of heme oxygenase in the brain, heart, liver, bone marrow, organ transplant, lung and kidney, opens many areas of investigation in various dis ciplines. Advances in the pharmacology of bilirubin and its ability as an antioxidant have provided a new avenue in clinical research.
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