Given the very limited capacity of regeneration in the brain, protecting neurons that are on the brink of death is a major challenge for basic and clinical neuroscience, with implications for a broad spectrum of acute and chronic neurological and psychiatric diseases. This book brings together leading experts from neurobiology, neurophysiology, neuropharmacology, neuroimmunology and clinical neuroscience to highlight the most recent milestones in this rapidly evolving field. The book will serve as a reference for both basic neuroscientists and clinicians interested in an authoritative update on the molecular and cellular biology of neuroprotection and its promises for new therapeutic strategies.
I: Neuronal Cell Death - Overview of Basic Mechanisms. 1. Excitatory amino acid neurotoxicity; T. Gillessen, et al. 2. Neuronal survival and cell death signaling pathways; R.S. Morrison, et al. 3. Detrimental and beneficial effects of injury-induced inflammation and cytokine expression in the nervous system; G. Stoll. 4. Cellular and molecular determinants of glial scar formation; A. Logan, M. Berry. II: Ion Channels, Receptors and Signaling Pathways. 5. Na+ channels and Ca2+ channels of the cell membrane as targets of neuroprotective substances; C. Alzheimer. 6. Intracellular Ca2+ handling; R.J. Sayer. 7. Neuroprotective activity of metabotropic glutamate receptor ligands; P.J. Flor, et al. 8. A role for glutamate transporters in neurodegenerative diseases; D. Trotti. 9. Purines and neuroprotection; T.W. Stone. 10. Heat shock proteins and neuroprotection; M.A. Yenari. III: Neurotrophic Factors as Neuroprotective Agents. 11. Neurotrophins; G. Dechantl, H. Neumann. 12. Fibroblast growth factors and neuroprotection; C. Alzheimer, S. Werner. 13. TGF-betas and their roles in the regulation of neuron survival; K. Unsicker, K. Krieglstein. 14. Vascular endothelial growth factor; H.H. Marti. IV: Advances in Drug Delivery to CNS Neurons. 15. Blood-brain barrier drug targeting enables neuroprotection in brain ischemia following delayed intravenous administration of neurotrophins; W.M. Pardridge. 16. Invasive drug delivery; U. Blömer, et al. V: Neuroprotective strategies in animal and in vitro models of neuronal damage. 17. Ischemia and stroke; M. Endres, U. Dirnagl. 18. Neuroprotective strategies in Alzheimer's disease; C. Behl. Index.
I. Neuronal Cell Death Overview of Basic Mechanisms.- 1. Excitatory Amino Acid Neurotoxicity.- 2. Neuronal Survival and Cell Death Signaling Pathways.- 3. Detrimental and Beneficial Effects of Injury-Induced Inflammation and Cytokine Expression in the Nervous System.- 4. Cellular and Molecular Determinants of Glial Scar Formation.- II. Ion Channels, Receptors and Signaling Pathways.- 5. Na+ Channels and Ca 2+ Channels of the Cell Membrane As Targets of Neuroprotective Substances.- 6. Intracellular Ca2+ Handling.- 7. Neuroprotective Activity of Metabotropic Glutamate Receptor Ligands.- 8. A Role for Glutamate Transporters in Neurodegenerative Diseases.- 9. Purines and Neuroprotection.- 10. Heat Shock Proteins and Neuroprotection.- III. Neurotrophic Factors as Neuroprotective Agents.- 11. Neurotrophins.- 12. Fibroblast Growth Factors and Neuroprotection.- 13. TGF-ßS and Their Roles in the Regulation of Neuron Survival.- 14. Vascular Endothelial Growth Factor.- IV. Advances in Drug Delivery to CNS Neurons.- 15. Blood-Brain Barrier Drug Targeting Enables Neuroprotection in Brain Ischemia Following Delayed Intravenous Administration of Neurotrophins.- 16. Invasive Drug Delivery.- V. Neuroprotective Strategies in Animal and in Vitro Models of Neuronal Damage.- 17. Ischemia and Stroke.- 18. Neuroprotective Strategies in Alzheimer's Disease.
Inhaltsverzeichnis
I. Neuronal Cell Death Overview of Basic Mechanisms.- 1. Excitatory Amino Acid Neurotoxicity.- 2. Neuronal Survival and Cell Death Signaling Pathways.- 3. Detrimental and Beneficial Effects of Injury-Induced Inflammation and Cytokine Expression in the Nervous System.- 4. Cellular and Molecular Determinants of Glial Scar Formation.- II. Ion Channels, Receptors and Signaling Pathways.- 5. Na+ Channels and Ca 2+ Channels of the Cell Membrane As Targets of Neuroprotective Substances.- 6. Intracellular Ca2+ Handling.- 7. Neuroprotective Activity of Metabotropic Glutamate Receptor Ligands.- 8. A Role for Glutamate Transporters in Neurodegenerative Diseases.- 9. Purines and Neuroprotection.- 10. Heat Shock Proteins and Neuroprotection.- III. Neurotrophic Factors as Neuroprotective Agents.- 11. Neurotrophins.- 12. Fibroblast Growth Factors and Neuroprotection.- 13. TGF-ßS and Their Roles in the Regulation of Neuron Survival.- 14. Vascular Endothelial Growth Factor.- IV. Advances in Drug Delivery to CNS Neurons.- 15. Blood-Brain Barrier Drug Targeting Enables Neuroprotection in Brain Ischemia Following Delayed Intravenous Administration of Neurotrophins.- 16. Invasive Drug Delivery.- V. Neuroprotective Strategies in Animal and in Vitro Models of Neuronal Damage.- 17. Ischemia and Stroke.- 18. Neuroprotective Strategies in Alzheimer's Disease.
Klappentext
Given the very limited capacity of regeneration in the brain, protecting neurons that are on the brink of death is a major challenge for basic and clinical neuroscience, with implications for a broad spectrum of acute and chronic neurological and psychiatric diseases. This book brings together leading experts from neurobiology, neurophysiology, neuropharmacology, neuroimmunology and clinical neuroscience to highlight the most recent milestones in this rapidly evolving field. The book will serve as a reference for both basic neuroscientists and clinicians interested in an authoritative update on the molecular and cellular biology of neuroprotection and its promises for new therapeutic strategies.
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