Since 1966, at ro~ghly three-yearly intervals, an internation al group of immunologists has met somewhere in Europe to discuss the latest developments in our understanding of the mechanisms governing the functioning of the immune system in vivo. These meetings have become known as the International C,mferences on Lymphatic Tissues and Germinal Centers in Immune Reactions, or for the regular devotees, simply as the Germinal Cent'~r Conferences (GCC). This volume represents the proceedings of the 8th GCC, which was held in Babraham, near Cambridge, UK, between the 14th and 17th August, 1984. When one considers how cellular immunology has become increas ingly dominated by in vitro methodology over the past twenty years, it may seem remarkable that these conferences·hav~ survived at all, let alone prospered. However, I for one do not find this surprising, since I suspect that the exquisitely :omplex architect ure and microenvironments of the lymphoid system will never be fully understood through in vitro studies. If "tae proper study of mankind is ~an", then surely ultimately the proper study of all the interacting elements which comprise the immune system has to be in vivo. This belief is shared by a substantial number of immunol ogists, as the contents of this volume will attest. Although the GCC were originally devoted to unravelling the mysteries of the germinal center response (and these are still not fully resolved), over the years the scope of the meetings has inevitably broadened.
B-Cell Differentiation, Subpopulations, the Role of Germinal Centers.- Prospects for Understanding the Role of Lymphoid Microenvironments in B Cell Differentiation in Vivo.- Pre-B Cells in Rat Bone Marrow: Identification, Surface Markers and Isolation.- T Cell Markers on Pre-B cells in the Rat.- Ig Light Chain Gene Rearrangement and Chromosomal Abnormality in the LAMA Early B-Lineage Tumour of the Rat.- In Vivo Regulation of B Lymphocyte Production in the Bone Marrow: Effects and Mechanism of Action of Exogenous Stimuli on Pre-B Cell Proliferation and Lymphocyte Turnover.- Influence of the Xid Mutation on B Lymphocyte Development in Adult Mice.- In Vitro Growth and Differentiation of Rat B Cell Subpopulations.- B Cell Production in Adult Rats.- The Paradox of High Rates of B Cell Production in Bone Marrow and the Longevity of Most Mature B cells.- Monoclonal Antibodies to Rat B Lymphocyte (Sub-)Populations.- Effect of Early Embryonic Bursectomy on Lymphocyte Differentiation and Maturation.- Evidence for the Existence of Two Distinct Types of Peyer's Patches in Sheep.- Evidence of Differences Between Peyer's Patches and Germinal Centers.- Differentiation of B Lymphocytes in Sheep. II. Surface Phenotype of B Cells leaving the 'Bursa-Equivalent' Lymphoid Tissue of Sheep, Ileal Peyer's Patches.- Origin and Fate of IgE-Bearing Lymphocytes: Modulation of IgE Isotype Expression on Peyer's Patch Cells.- Immunoglobulin Isotypes and Antibody Specificity Repertoire of "Spontaneously" Occurring Ig-Secreting Cells in Germfree Mice Fed Chemically Defined UltraFiltered, Antigen-Free Diet.- Comparative Analysis of the Development of B Cells in Marginal Zones and Follicles.- Germinal Center Cells: Antigen Specificity, Heavy Chain Class Expression and Evidence of Memory.- The Development of Specific Antibody Producing Cells in the Spleen of Rabbits During the Primary and Secondary Immune Response.- The Ontogenetic Development of the Follicular Dendritic Cell in Rat Spleen.- Origin and Turnover of Follicular Dendritic Cells and Marginal Zone Macrophages in the Mouse Spleen.- Mouse Lymph Node Follicular Dendritic Cells: Quantitative Analysis and Isolation.- Antigen/Antibody Retention by Follicular Dendritic Cells.- Antigenic Phenotype of Rodent Follicular Dendritic Cells in Vitro and in Situ.- B Cell Differentiation: B Cell Subsets and Factors, Organs or Structures involved in B Lymphocyte Genesis.- Thymus and T Cell Differentiation.- Precursors of T-Cell Mitogen Reactive Cells and Their Suppressors in the Mouse Fetal Liver.- Thymus Homing Clonogenic Bone Marrow Cells.- The Role of the Thymic Cortex and Medulla in T Cell Differentiation.- Intrathymic Differentiation in the Rat.- Stromal Cell Populations in the Developing Thymus of Normal and Nude Mice.- New Surface Antigens on Cells in the Early Phase of T-Cell Differentiation, Detected by Monoclonal Antibodies.- Studies on the Role of the Thymus in the Selection and Clonal Expansion of T-Cell Precursors.- Culture of Mouse Thymic Epithelial Cells and Studies of Age-Related Changes.- Heterogeneity of Human Thymus Epithelial Cells Revealed by Monoclonal Anti-Epithelial Cell Antibodies.- Heterogeneity of the Human Thymus Epithelial Microenviroilment at the Utrastructural Level.- T Cell Differentiation Within TNC Related Lympho-Epithelial Complexes in the Thymus Cortex.- The Relation Between Thymic Interdigitating Cells and Dendritic Cells.- "T-Cells" in Nude Rats.- T-Cells and T-Cell Subsets in Rat Bronchus-Associated Lymphoid Tissue (BALT) in Situ and in Suspension.- K Cell Activity is Independent of Both Thymus and Spleen.- Use of Transgenic Mice with Human MHC Class 1 Gene (HLA-A2).- Effect of Sympathectomy on the Maturation of Fetal Thymocytes Grown Within the Anterior Eye Chambers in Mice.- The Effect of Dioctyltin Dichloride on the Thymus and T Cell Differentiation in the Rat.- Structural Astpect of Immune Induction.- Antibody Responses to T-Dependent Antigens: Contributions of Dendritic C
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