Foreword, Shirley Ebbe. Part I: Introduction. Megakaryocyte Biology, Carl W. Jackson, Julie T. Arnold, Tamara I. Pestina, and Paula E. Stenberg. Platelet Structure and Function, Dorothea Zucker-Franklin. The Evolution of Mammalian Platelets, Jack Levin. Potential Clinical Applications of Thrombopoietic Growth Factors, Charles A. Schiffer. Part II: The Search for the Physiologic Regulator of Platelet Production. Historical Perspective and Overview, Eric M. Mazur. The Murine Myeloproliferative Leukemia Virus MPLV, v-mpl Oncogene, and c-mpl, Françoise Wendling and Sylvie Gisselbrecht. Mpl Expression and Functional Role in Human Megakaryocytopoiesis, Françoise Wendling, Najet Debili, and William Vainchenker. The Purification and Cloning of Human Thrombopoietin, Dan Eaton. The Purification of Thrombopoietin from Thrombocytopenic Plasma, David J. Kuter, Hiroshi Miyazaki, and Takashi Kato. The Role of Other Hemopoietic Growth Factors and the Marrow Microenvironment in Megakaryocytopoiesis, Ronald Hoffman. Part III: Molecular Biology. Structure of Thrombopoietin and the Thrombopoietin Gene, Austin L. Gurney and Frederic J. de Sauvage. Transcription Factors in Megakaryocyte Differentiation and Gene Expression, Ramesh A. Shivdasani. The Biological Significance of Truncated and Full-Length Forms of Mpl Ligands, Donald Foster and Pamela Hunt. Part IV: Cellular Biology. In Vitro Effects of Mpl Ligand on Human Hemopoietic Progenitor Cells, Najet Debili, Elisabeth Cramer, Françoise Wendling, and William Vainchenker. Effect of Cytokines on the Development of Megakaryocytes and Platelets: An Ultrastructural Analysis, Dorothea Zucker-Franklin. The Thrombopoietin Receptor, Mpl, and Signal Transduction, Kenneth Kaushansky, Virginia C. Broudy, and Jonathan G. Drachman. Regulation of Proplatelet and Platelet Formation In Vitro, Esther Choi. In Vitro Effects of Mpl Ligands on Platelet Function, Laurence A. Harker, Ulla M. Marzec, and Christopher F. Toombs. Part V: Preclinical Biology.In Vivo Dose-Response Effects of Mpl Ligands and Platelet Production and Function, Laurence A. Harker, Christopher F. Toombs, and Richard B. Stead. Efficacy of Mpl Ligands and other Thrombopoietic Cytokines in Animal Models, Ann M. Farese and Thomas J. MacVittie. Genetic Manipulation of Mpl Ligand and Thrombopoietin In Vivo, Frederic J. de Sauvage and Mark W. Moore. Part VI: Clinical Biology. Serum Levels of Thrombopoietin in Health and Disease, Janet Lee Nichol. The Regulation of Platelet Production In Vivo, David J. Kuter. Glossary. Index.
David Kuter and a host of leading international researchers summarize in one volume all the knowledge of thrombopoietins (TPO) available today. The distinguished experts review the history of the search to discover TPO, describe the molecular and biological characteristics of this new molecule, and present the results of the preclinical animal experiments that will guide clinical use of this new hormone. Along the way they provide the most recent and comprehensive guide to the biology of megakaryocytes and platelets.
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