1. Cardiovascular Function.- 1. Cardiovascular Concepts in Antiquity.- 2. A New Approach to the Analysis of Cardiovascular Function: Allometry.- 2. Cardiac Muscle.- 3. Muscle Contraction Mechanics from Ultrastructural Dynamics.- 4. Crossbridge Cycling and Cooperative Recruitment Can Account for Oscillatory Dynamics of Constantly Activated Heart.- 5. Modeling Reversible Mechanical Dysfunction in the Stunned Myocardium.- 6. Computer-Based Myocardial Tissue Characterization Using Quantitative Description of Texture.- 3. Coronary Circulation.- 7. Interpretation of Coronary Vascular Perfusion.- 8. New-Age Rapid Diagnosis of Acute Myocardial Injury.- 4. Ventricular Dynamics.- 9. Modeling of the Effects of Aortic Valve Stenosis and Arterial System Afterload on Left Ventricular Hypertrophy.- 10. Ventricular Shape: Spherical or Cylindrical?.- 11. Pathophysiology of Diastole and Left Ventricular Filling in Humans: Noninvasive Evaluation.- 12. Echocardiographic Evaluation of Thrombolytic Intervention After Acute Myocardial Infarction.- 5. Arterial/Ventricular Circulation.- 13. Modeling of Noninvasive Arterial Blood Pressure Methods.- 14. Measurement and Applications of Arterial and Ventricular Pressure-Dimension Relationships in Animals and Humans.- 6. Microcirculation.- 15. Quantitative Analysis of the Lee Method for Determination of the Capillary Filtration Coefficient.- 16. Assessment of Human Microvascular Function.- 7. Venous System.- 17. Dynamic Response of the Collapsible Blood Vessel.- 8. Electrophysiology.- 18. Microvolt-Level T Wave Alternans as a Marker of Vulnerability to Cardiac Arrhythmias: Principles and Detection Methods.- 19. Quantification of Heart Rate Variability Using Methods Derived from Nonlinear Dynamics.- 20. Transesophageal Electrophysiology.- 21. Occurrence and Diagnostic Importance of Postural ST-Segment Depression in Ambulatory Holter Monitoring in Male Patients After Myocardial Infarction.
The objective of this book is to provide the researcher and clinician with the recent developments in the analysis and assessment of cardiovascular func tion. The chapters are organized into sections that correspond with the various anatomical levels of the cardiovascular system. To a large extent, recent focus on the cardiovascular system function has been directed at the molecular level to the near exclusion of the tissue and organ function. While this may be useful in developing new therapeutic drugs, it does not aid the cardiologist or surgeon, who routinely deal with patient symptoms. This book integrates the micro-level and organ-level function so that new infor mation may be assimilated into the cardiovascular system as a whole. Within each section, the chapters have been arranged to progress from recent theoretical developments, to experimental research, and finally to clinical applications. This approach facilitates the timely transfer of infor mation from basic research to the clinic. The strength of the analytical approach will be evident to the reader. The theoretical analysis offers guidance to experimental design and, in some cases, offers solutions where measurements are as yet unattainable. In moving from newly attained knowledge to clinical practice, this book emphasizes the noninvasive meth in the future as technological advances ods. Such methods are desirable occur and the trend towards early preventive diagnosis is sought. What follows are highlights of new developments covered in each section of the book.
The function of the heart and the vascular system is vital to modern biomedical research. This book integrates research at the level of cells with that at the level of tissues and organs. It focuses on methods of assessing the function of the cardiovascular system at different anatomical levels using a combination of analytical, experimental, and clinical measurements.