Offers a state-of-the-art review by international experts on all aspects of tachykinin receptors, including neuropeptide/peptide and G-protein-linked receptors in general. It covers the physiology, pharmacology, biochemistry, and molecular biology of these receptors from both clinical and basic research points of view.
Topics treated by the distinguished contributors include the characterization of tachykinin receptors, the mechanisms of tachykinin receptor action, a reflection on future prospects, and a historical consideration of tachykinin research.
Section 1: Historical Perspectives of Tachykinins: History of Tachykinin Peptides. History of Tachykinin Receptors. Section 2: Characterization of Tachykinin Receptors: Biochemical Methods and Assays for Receptors. Agonist and Antagonist Binding to Receptors. Comparative Distribution of Receptor Types in Mammalian Brain. Autoradiographic Localization of Receptors in Peripheral Tissues. Molecular Biology of Receptors: Structures, Expression, and Regulatory Mechanisms. Characterization of the NK1 Receptor Using Photoaffinity Probes. Modeling of G-Protein-Coupled Receptors: Application to the Tachykinin NK1 Receptor. Section 3: Mechanisms of Tachykinin Receptor Action: Tachykinin Receptors and the Inositol Phosphate Calcium Signaling System. Signal Transduction Mechanisms of Tachykinin Effects on Ion Channels. Section 4: Tachykinin Receptor Function: Structure-Activity Relationships of Agonist and Antagonist Ligands. Pharmacological Characterization of Receptor Types. Evidence for Receptor Subtypes/Species Variants of Receptors. Role of Receptors in Nociception. Pharmacological Characterization of Receptors in the Spinal Cord of the Newborn Rat. Receptor Function in the Periphery. Receptor Involvement in Pathology and Disease. Section 5: Summary and Future Perspectives: Summary, Thoughts, and Future Perspectives. Index.
...the major advances in this exciting area of neuropeptide biology are expertly reviewed by many of the leading investigators in this field...a useful volume to both the expert and the uninitiated...the contributors have succeeded in providing the most current information in this field...a well-written and organized text that is a pleasure to read. - Endocrine
I. Historical Perspectives of Tachykinins.- 1 History of Tachykinin Peptides 1.- 2 History of Tachykinin Receptors 23.- II. Characterization of Tachykinin Receptors.- 3 Biochemical Methods and Assays 39.- 4 Agonist and Antagonist Receptor Binding.- 5 Comparative Distribution of Receptor Types in the Mammalian Brain 101.- 6 Autoradiographic Localization of Receptors in Peripheral Tissues 125.- 7 Molecular Biology of Receptors: Structures, Expression,and Regulatory Mechanisms 165.- 8 Characterization of the NKl Receptor Using Photoaffinity Probes 219.- 9 Modeling of G-Protein-Coupled Receptors: Application to the NK1Tachykinin Receptor 237.- III. Mechanisms of Tachykinin Receptor Action.- 10 Receptors and the Inositol Phosphate-Calcium Signaling System 257.- 11 Signal Transduction Mechanisms of Tachykinin Effects on Ion Channels 285.- IV. Tachykinin Receptor Function.- 12 Structure-Activity Relationships of Agonist and Antagonist Ligands 329.- 13 Pharmacological Characterization of Receptor Types 367.- 14 Evidence for Receptor Subtypes/Species Variants of Receptors. 395.- 15 Role of Receptors in Nociception 471.- 16 Pharmacological Characterization of Receptors in the Spinal Cord of the Newborn Rat 499.- 17-Receptor Function in the Periphery 515.- 18 Receptor Involvement in Pathology and Disease 581.- V. Summary and Future Perspectives.- 19 Summary, Thoughts, and Future Perspectives 611.
Inhaltsverzeichnis
Section 1: Historical Perspectives of Tachykinins: History of Tachykinin Peptides. History of Tachykinin Receptors. Section 2: Characterization of Tachykinin Receptors: Biochemical Methods and Assays for Receptors. Agonist and Antagonist Binding to Receptors. Comparative Distribution of Receptor Types in Mammalian Brain. Autoradiographic Localization of Receptors in Peripheral Tissues. Molecular Biology of Receptors: Structures, Expression, and Regulatory Mechanisms. Characterization of the NK1 Receptor Using Photoaffinity Probes. Modeling of G-Protein-Coupled Receptors: Application to the Tachykinin NK1 Receptor. Section 3: Mechanisms of Tachykinin Receptor Action: Tachykinin Receptors and the Inositol Phosphate Calcium Signaling System. Signal Transduction Mechanisms of Tachykinin Effects on Ion Channels. Section 4: Tachykinin Receptor Function: Structure-Activity Relationships of Agonist and Antagonist Ligands. Pharmacological Characterization of Receptor Types. Evidence for Receptor Subtypes/Species Variants of Receptors. Role of Receptors in Nociception. Pharmacological Characterization of Receptors in the Spinal Cord of the Newborn Rat. Receptor Function in the Periphery. Receptor Involvement in Pathology and Disease. Section 5: Summary and Future Perspectives: Summary, Thoughts, and Future Perspectives. Index.
Klappentext
Offers a state-of-the-art review by international experts on all aspects of tachykinin receptors, including neuropeptide/peptide and G-protein-linked receptors in general. It covers the physiology, pharmacology, biochemistry, and molecular biology of these receptors from both clinical and basic research points of view.nnnnTopics treated by the distinguished contributors include the characterization of tachykinin receptors, the mechanisms of tachykinin receptor action, a reflection on future prospects, and a historical consideration of tachykinin research.
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