SECTION 1: General aspects of vaccination
1 A short history of vaccination 1
2 Vaccine immunology 14
3 The vaccine industry 33
4 Vaccine manufacturing 44
5 Evolution of adjuvants across the centuries 58
6 Vaccine additives and manufacturing residuals in the United States:
licensed vaccines 71
7 Passive immunization 80
8 General immunization practices 88
SECTION 2: Licensed vaccines
9 Adenovirus vaccines 113
10 Anthrax vaccines 127
11 Cholera vaccines 141
12 Diphtheria toxoid 153
13 Haemophilus influenzae vaccines 167
14 Hepatitis A vaccines 183
15 Hepatitis B vaccines 205
16 Human papillomavirus vaccines 235
17 Inactivated influenza vaccines 257
18 Influenza vaccine-live 294
19 Japanese encephalitis vaccines 312
20 Measles vaccines 352
21 Meningococcal vaccines 388
22 Mumps vaccine 419
23 Pertussis vaccines . 447
24 Plague vaccines 493
25 Pneumococcal conjugate vaccine and pneumococcal common protein vaccines 504
26 Pneumococcal polysaccharide vaccines 542
27 Poliovirus vaccine-inactivated . 573
28 Poliovirus vaccine-live 598
29 Rabies vaccines .646
30 Rotavirus vaccines . 669
31 Rubella vaccine 688
32 Smallpox and vaccinia 718
33 Tetanus toxoid 746
34 Tick-borne encephalitis virus vaccines 773
35 Tuberculosis vaccines 789
36 Typhoid fever vaccines 812
37 Varicella vaccine 837
38 Yellow fever vaccine 870
39 Zoster vaccine 969
40 Combination vaccines 981
SECTION 3: Vaccines in development and new vaccine strategies
41 Biodefense and special pathogen vaccines 1008
42 Therapeutic cancer vaccines 1018
43 Cytomegalovirus vaccines 1032
44 Dengue vaccines 1042
45 Diarrhea caused by bacteria 1052
46 Ebola vaccine 1060
47 Epstein-Barr virus vaccines 1068
48 Hepatitis C vaccines 1074
49 Hepatitis E vaccines 1085
50 Herpes simplex virus vaccines 1090
51 Human immunodeficiency virus vaccines 1097
52 Lyme disease vaccines 1122
53 Malaria vaccines 1133
54 Noninfectious disease vaccines 1138
55 Respiratory syncytial virus and parainfluenza virus vaccines 1146
56 Parasitic disease vaccines 1154
57 Staphylococcus aureus vaccines 1161
58 Streptococcus group A vaccines 1169
59 Streptococcus group B vaccines 1176
60 Technologies for making new vaccines 1182
61 Alternative vaccine delivery methods 1200
62 The development of gene-based vectors for immunization 1232
SECTION 4: Vaccination of special groups
63 Vaccination of immunocompromised hosts 1243
64 Vaccination of human immunodeficiency virus-infected persons 1257
65 Vaccines for international travel 1270
66 Vaccines for health care personnel 1290
SECTION 5: Public health and regulatory issues
67 Immunization in the United States 1310
68 Immunization in Europe . 1334
69 Immunization in the Asia-Pacific region 1353
70 Immunization in developing countries 1369
71 Community immunity 1395
72 Economic analyses of vaccine policies 1413
73 Regulation and testing of vaccines 1427
74 Regulation of vaccines in Europe 1447
75 Regulation of vaccines in developing countries 1454
76 Vaccine safety 1464
77 Legal issues . 1481
78 Ethics 1508
Inhaltsverzeichnis
Contents Foreword ix Preface to the first edition x Preface to the sixth edition x Preface by Editor in Chief xi List of Contributors xii Dedication xix Acknowledgements xix SECTION 1: General aspects of vaccination 1 A short history of vaccination 1 Susan L. Plotkin, Stanley A. Plotkin 2 Vaccine immunology 14 Claire-Anne Siegrist 3 The vaccine industry 33 R. Gordon Douglas, Vijay B. Samant 4 Vaccine manufacturing 44 Phillip L. Gomez, James M. Robinson, Joseph A. Rogalewicz 5 Evolution of adjuvants across the centuries 58 Nathalie Garcon, Stanley Hem, Martin Friede 6 Vaccine additives and manufacturing residuals in the United States: licensed vaccines 71 Theresa M. Finn, William Egan 7 Passive immunization 80 E. Richard Stiehm, Margaret A. Keller 8 General immunization practices 88 Andrew T. Kroger, William L. Atkinson, Larry K. Pickering SECTION 2: Licensed vaccines 9 Adenovirus vaccines 113 Gregory C. Gray 10 Anthrax vaccines 127 Arthur M. Friedlander, John D. Grabenstein, Phillip S. Brachman 11 Cholera vaccines 141 John D. Clemens, Sunheang Shin, Binod K. Sah, David A. Sack 12 Diphtheria toxoid 153 Tejpratap S. P. Tiwari, Melinda Wharton 13 Haemophilus influenzae vaccines 167 Aruna Chandran, James P. Watt, Mathuram Santosham 14 Hepatitis A vaccines 183 Trudy V. Murphy, Stephen M. Feinstone, Beth P. Bell 15 Hepatitis B vaccines 205 Pierre Van Damme, John Ward, Daniel Shouval, Steven Wiersma, Alessandro Zanetti 16 Human papillomavirus vaccines 235 John T. Schiller, Douglas R. Lowy, Lauri E. Markowitz 17 Inactivated influenza vaccines 257 Anthony E. Fiore, Carolyn B. Bridges, Jacqueline M. Katz, Nancy J. Cox 18 Influenza vaccine-live 294 Catherine J. Luke, Seema S. Lakdawala, Kanta Subbarao 19 Japanese encephalitis vaccines 312 Scott B. Halstead, Julie Jacobson, Katrin Dubischar-Kastner 20 Measles vaccines 352 Peter M. Strebel, Mark J. Papania, Amy Parker Fiebelkorn, Neal A. Halsey 21 Meningococcal vaccines 388 Dan M. Granoff, Stephen Pelton, Lee H. Harrison 22 Mumps vaccine 419 Steven A. Rubin, Stanley A. Plotkin 23 Pertussis vaccines . 447 Kathryn M. Edwards, Michael D. Decker 24 Plague vaccines 493 E. Diane Williamson, Petra C. F. Oyston 25 Pneumococcal conjugate vaccine and pneumococcal common protein vaccines 504 Keith P. Klugman, Steven Black, Ron Dagan, Richard Malley, Cynthia G. Whitney 26 Pneumococcal polysaccharide vaccines 542 Lisa A. Jackson 27 Poliovirus vaccine-inactivated . 573 Emmanuel Vidor, Stanley A. Plotkin 28 Poliovirus vaccine-live 598 Roland W. Sutter, Olen M. Kew, Stephen L. Cochi, R. Bruce Aylward 29 Rabies vaccines .646 Charles E. Rupprecht, Stanley A. Plotkin 30 Rotavirus vaccines . 669 H. Fred Clark, Paul A. Offit, Umesh D. Parashar 31 Rubella vaccine 688 Susan E. Reef, Stanley A. Plotkin 32 Smallpox and vaccinia 718 Richard B. Kennedy, J. Michael Lane, Donald A. Henderson, Gregory A. Poland 33 Tetanus toxoid 746 Martha H. Roper, Steven G. F. Wassilak, Tejpratap S. P. Tiwari, Walter A. Orenstein 34 Tick-borne encephalitis virus vaccines 773 P. Noel Barrett, Daniel Portsmouth, Hartmut J. Ehrlich 35 Tuberculosis vaccines 789 Kim Connelly Smith, Ian M. Orme, Jeffrey R. Starke 36 Typhoid fever vaccines 812 Myron M. Levine 37 Varicella vaccine 837 Anne A. Gershon, Michiaki Takahashi, Jane F. Seward 38 Yellow fever vaccine 870 Thomas P. Monath, Mark Gershman, J. Erin Staples, Alan D. T. Barrett 39 Zoster vaccine 969 Myron J. Levin 40 Combination vaccines 981 Michael D. Decker, Kathryn M. Edwards, Hugues H. Bogaerts SECTION 3: Vaccines in development and new vaccine strategies 41 Biodefense and special pathogen vaccines 1008 Phillip R. Pittman, Stanley A. Plotkin 42 Therapeutic cancer vaccines 1018 Neil L. Berinstein, Jeffrey A. Berinstein 43 Cytomegalovirus vaccines 1032 Mark R. Schleiss, Stanley A. Plotkin 44 Dengue vaccines 1042 Scott B. Halstead, Stephen J. Thomas 45 Diarrhea caused by bacteria 1052 James P. Nataro, Eileen M. Barry 46 Ebola vaccine 1060 Nancy J. Sullivan, Hugues F. Fausther-Bovendo, Gary J. Nabel 47 Epstein-Barr virus vaccines 1068 Viviana P. Lutzky, Denis J. Moss 48 Hepatitis C vaccines 1074 Sergio Abrignani, Eva Reali, Michael Houghton, Raffaele De Francesco 49 Hepatitis E vaccines 1085 Robert H. Purcell, Suzanne U. Emerson 50 Herpes simplex virus vaccines 1090 Lawrence R. Stanberry, Robert B. Belshe 51 Human immunodeficiency virus vaccines 1097 Marc P. Girard, Wayne C. Koff 52 Lyme disease vaccines 1122 Allen C. Steere, Ian Livey 53 Malaria vaccines 1133 W. Ripley Ballou, Joe Cohen 54 Noninfectious disease vaccines 1138 Philippe Saudan, Martin F. Bachmann 55 Respiratory syncytial virus and parainfluenza virus vaccines 1146 Ruth A. Karron 56 Parasitic disease vaccines 1154 Peter J. Hotez, Jeffrey M. Bethony 57 Staphylococcus aureus vaccines 1161 Robert S. Daum 58 Streptococcus group A vaccines 1169 Karen L. Kotloff 59 Streptococcus group B vaccines 1176 C. Mary Healy, Carol J. Baker 60 Technologies for making new vaccines 1182 Ronald W. Ellis, Rino Rappuoli, Sohail Ahmed 61 Alternative vaccine delivery methods 1200 Bruce G. Weniger, Mark J. Papania 62 The development of gene-based vectors for immunization 1232 David B. Weiner, Gary J. Nabel SECTION 4: Vaccination of special groups 63 Vaccination of immunocompromised hosts 1243 Per Ljungman 64 Vaccination of human immunodeficiency virus-infected persons 1257 William J. Moss, Catherine G. Sutcliffe, Neal A. Halsey 65 Vaccines for international travel 1270 Elizabeth D. Barnett, Phyllis E. Kozarsky, Robert Steffen 66 Vaccines for health care personnel 1290 David J. Weber, William A. Rutala SECTION 5: Public health and regulatory issues 67 Immunization in the United States 1310 Lance E. Rodewald, Walter A. Orenstein, Alan R. Hinman, Anne Schuchat 68 Immunization in Europe . 1334 David M. Salisbury, Rebecca M. Martin, Pierre Van Damme, Pier Luigi Lopalco 69 Immunization in the Asia-Pacific region 1353 Theodore F. Tsai, Hans Bock, Zhi Yi Xu 70 Immunization in developing countries 1369 Violaine Mitchell, Vance J. Dietz, Jean Marie Okwo-Bele, Felicity T. Cutts 71 Community immunity 1395 Paul E. M. Fine, Kim Mulholland 72 Economic analyses of vaccine policies 1413 Mark A. Miller, Alan R. Hinman 73 Regulation and testing of vaccines 1427 Norman W. Baylor, Valerie B. Marshall 74 Regulation of vaccines in Europe 1447 Falk Ehmann, Xavier Kurz, Marco Cavaleri, Peter R. Arlett 75 Regulation of vaccines in developing countries 1454 Lahouari Belgharbi, Nora Dellepiane, David J. Wood 76 Vaccine safety 1464 Paul A. Offit, Frank DeStefano 77 Legal issues . 1481 Geoffrey Evans, Emily Marcus Levine, Anna L. Jacobs 78 Ethics 1508 Arthur L. Caplan, Jason L. Schwartz Appendix 1514 Deborah L. Wexler, Teresa A. Anderson, Mary R. Quirk Index .1521
