This book describes core processes of replication, mutation, neutral evolution and natural selection, genome evolution in prokaryotes, eukaryotes, vertebrates and humans, genome sequencing amd more, offering worked-out examples and extensive appendices.
Evolutionary genomics is a new field that bridges molecular evolution, bioinformatics and genomics. Part 1 describes the core processes of replication, transcription and translation, followed by mutation, phylogeny, neutral evolution and natural selection. Part 2 describes genome evolution in prokaryotes, eukaryotes, vertebrates and humans. Part 3 covers genome sequencing, phenotype data collection, databases and homology searches. Part 3 then focuses on nucleotide sequence analysis, including multiple alignments, evolutionary distance computation, phylogenetic tree/network construction and gene genealogy. The relationships between genome sequences and phenotypes are then discussed, and the final chapter of Part 3 contains worked-out examples of evolutionary genomic studies. The appendices comprise Part 4, which supply historical perspectives and statistical tests in addition to some basic facts, such as genetic code tables, the geological time table, and a brief classification of all organisms.
Part I: Basic Processes of Genome Evolution
Basic Metabolism Surrounding DNAs
Mutation
Phylogeny
Neutral Evolution
Natural Selection
Part II: Evolving Genomes
Brief History of Life
Prokaryote Genomes
Eukaryote Genomes
Vertebrate Genomes
Human Genomes
Part III: Methods for Evolutionary Genomics
Genome Sequencing
Omic Data Collection
Databases
Sequence Homology Handling
Evolutionary Distances
Tree and Network Building
Population Genomics
1
Über den Autor
Dr. Naruya Saitou is a Professor in the Division of Population Genetics at the National Institute of Genetics, and a Professor in the Department of Genetics at the Graduate University for Advanced Studies, Mishima, Japan. He is also a Professor in the Department of Biological Sciences at the University of Tokyo, Japan.
Inhaltsverzeichnis
Part I: Basic Processes of Genome Evolution
Basic Metabolism Surrounding DNAs
Mutation
Phylogeny
Neutral Evolution
Natural Selection
Part II: Evolving Genomes
Brief History of Life
Prokaryote Genomes
Eukaryote Genomes
Vertebrate Genomes
Human Genomes
Part III: Methods for Evolutionary Genomics
Genome Sequencing
Omic Data Collection
Databases
Sequence Homology Handling
Evolutionary Distances
Tree and Network Building
Population Genomics
Klappentext
This book is the first of its kind to explain the fundamentals of evolutionary genomics. The comprehensive coverage includes concise descriptions of a variety of genome organizations, a thorough discussion of the methods used, and a detailed review of genome sequence processing procedures. The opening chapters also provide the necessary basics for readers unfamiliar with evolutionary studies. Features: introduces the basics of molecular biology, DNA replication, mutation, phylogeny, neutral evolution, and natural selection; presents a brief evolutionary history of life from the primordial seas to the emergence of humans; describes the genomes of prokaryotes, eukaryotes, vertebrates, and humans; reviews methods for genome sequencing, phenotype data collection, homology searches and analysis, and phylogenetic tree and network building; discusses databases of genome sequences and related information, evolutionary distances, and population genomics; provides supplementary material at an associated website.
The first textbook on the new field of evolutionary genomics
Discusses in detail a series of genome sequence processing procedures
Provides supplementary material at an associated website
