- Introductory text to bone metastases for orthopaedic surgeons - International experts have written chapters on specific aspects on diagnosis and treatment of bone metastases - Describes multidisciplinary treatments that combine surgery, radiotherapy and chemotherapy
An introductory text on bone metastases written by experts from various disciplines. It covers the basic principles of surgery in bone cancer, classification, medical treatment, radiotherapy, surgical treatment, incidence and pain relief. The steady progress in diagnosis and treatment of bone cancer in the last decade has dramatically changed the prognosis of cancer patients, improving significantly the overall survival rate and quality of life. Multidisciplinary treatments that combine surgery, radiotherapy and chemotherapy, as described in this book, show significantly improved results and an above average survival rate. Some hematologic malignancies that involve bone may be cured with systemic chemotherapy or radiotherapy, but for most patients with bone metastases, pain relief is the goal of therapy.|This book will be an introduction to bone metastases for orthopaedic surgeons. It covers the basic principles of surgery in bone cancer; radiographic imaging of skeletal metastases; classification; medical treatment; radiotherapy; surgical treatment, incidence and pain relief.
Steady progress in diagnosis and treatment of bone cancer in the last decade has dramatically changed the prognosis of cancer patients, significantly improving their overall survival rate and quality of life.
Some haematologic malignancies that involve bone may be cured with systemic chemotherapy or radiotherapy, but for most patients with bone metastases, pain relief is the goal of therapy.
Bone Metastases - Medical, Surgical and Radiological Treatment is written by a multidisciplinary team of experts to provide comprehensive coverage of metastatic bone disease.
Dominique G. Poitout is Professor of Surgery and Head of Orthopaedic Department at North Hospital, Marseille, France|This title is an introductory text to bone metastases for orthopaedic surgeons. . It covers the basic principles of surgery in bone cancer; classification; medical treatment; radiotherapy; surgical treatment, incidence and pain relief. Bone metastases are a common cause of morbidity in cancer patients. The debilitating pain that occurs in many patients with advanced malignancies is primarily produced by bone metastases. While almost every malignancy can cause bone metastases, breast cancer, lung cancer, and prostate cancer account for more than 80% of bone metastases. Some hematologic malignancies that involve bone may be cured with systemic chemotherapy or radiotherapy, but for most patients with bone metastases, pain relief is the goal of therapy.
1 Histology and Experimental Study.- 1 Pathology of Bone Metastatic Tumours.- 1.1 Techniques and Choice of Bone Sample.- 1.2 Macroscopic Study.- 1.3 Histological Study.- 1.4 Mechanisms of Development of Bone Metastasis.- 1.5 Summary.- 2 Identification.- 2 Radiographic Imaging of Skeletal Metastases.- 2.1 Mechanisms of Bone Involvement.- 2.2 Osseous Response to Metastases.- 2.3 Radiographic Imaging.- 2.4 Role of the Radiographic Examination in the Evaluation of Skeletal Metastases.- 2.5 Summary.- 3 Medical Treatment.- 3 Chemotherapy.- 3.1 Problems of Response Assessment in Skeletal Metastases.- 3.2 Breast Cancer.- 3.3 Lung Cancer.- 3.4 Prostate Cancer.- 3.5 Renal Cell Carcinoma.- 3.6 Summary.- 4 Immunotherapy.- 4.1 Active Non-specific Immunotherapy.- 4.2 Active Specific Immunotherapy.- 4.3 Passive Immunotherapy.- 4.4 Interferons.- 4.5 Interleukin-2.- 4.6 Conclusion.- 5 Biphosphonates.- 5.1 Mechanism of Action.- 5.2 Bone Pain.- 5.3 Osteolytic Process.- 5.4 Prevention of Complications of Bone Metastases in Patients with Breast Cancer.- 5.5 Prevention of Bone Metastases Development in Patients with Breast Cancer.- 5.6 Summary.- 6 Hormonal Therapy.- 6.1 Introduction.- 6.2 Breast Cancer.- 6.3 Prostate Cancer.- 6.4 Endometrial Cancer.- 7 Cement-Containing Antimitotics.- 7.1 Study of the Release of Methotrexate.- 7.2 Study of the Release of Cisplatin.- 7.3 Diffusion Mechanism of Antimitotics.- 7.4 Clinical Experience.- 7.5 Conclusion.- 4 Radiotherapy.- 8 Radiotherapy in the Treatment of Bone Metastases.- 8.1 Introduction.- 8.2 External Radiotherapy.- 8.3 Systemic Radiotherapy.- 8.4 Summary.- 9 Radiosurgical Treatment of Bone Metastasis of the Limbs.- 9.1 Introduction.- 9.2 Patients.- 9.3 Methods.- 9.4 Results.- 9.5 Discussion.- 9.6 Conclusion.- 5 Surgical Treatment.- 10 Surgery for Bone Metastasis of the Limbs.- 10.1 Introduction.- 10.2 Clinical Bases.- 10.3 Principles of Palliative Surgery for Bone Metastasis.- 10.4 Methods.- 10.5 Discussion.- 10.6 Conclusion.- 11 Surgical Treatment of Vertebral Metastases.- 11.1 Therapeutic Decision.- 11.2 Surgical Techniques.- 11.3 Results.- 11.4 Conclusion.- 12 Treatment of Secondary Spinal Tumours.- 12.1 Introduction.- 12.2 Consideration of the Primary Tumour.- 12.3 Surgery.- 12.4 Vertebroplasty.- 12.5 Conclusion.- 6 Medico-social Aspects.- 13 Caring for Cancer Patients.- 13.1 Introduction.- 13.2 Life, Birth and Death.- 13.3 Tridimensional Reality of Human Beings.- 13.4 What is Suffering?.- 13.5 Caring for Suffering People.- 13.6 Conclusion.- 7 Pain Relief.- 14 Therapeutic Approaches to Bone Cancer Pain.- 14.1 Introduction.- 14.2 Bone Metastases and Pain.- 14.3 Management of Bone Pain.- 14.4 Conclusion.- Conclusion.
1 Histology and Experimental Study.- 1 Pathology of Bone Metastatic Tumours.- 2 Identification.- 2 Radiographic Imaging of Skeletal Metastases.- 3 Medical Treatment.- 3 Chemotherapy.- 4 Immunotherapy.- 5 Biphosphonates.- 6 Hormonal Therapy.- 7 Cement-Containing Antimitotics.- 4 Radiotherapy.- 8 Radiotherapy in the Treatment of Bone Metastases.- 9 Radiosurgical Treatment of Bone Metastasis of the Limbs.- 5 Surgical Treatment.- 10 Surgery for Bone Metastasis of the Limbs.- 11 Surgical Treatment of Vertebral Metastases.- 12 Treatment of Secondary Spinal Tumours.- 6 Medico-social Aspects.- 13 Caring for Cancer Patients.- 7 Pain Relief.- 14 Therapeutic Approaches to Bone Cancer Pain.- Conclusion.
Inhaltsverzeichnis
1 Histology and Experimental Study.- 1 Pathology of Bone Metastatic Tumours.- 1.1 Techniques and Choice of Bone Sample.- 1.2 Macroscopic Study.- 1.3 Histological Study.- 1.4 Mechanisms of Development of Bone Metastasis.- 1.5 Summary.- 2 Identification.- 2 Radiographic Imaging of Skeletal Metastases.- 2.1 Mechanisms of Bone Involvement.- 2.2 Osseous Response to Metastases.- 2.3 Radiographic Imaging.- 2.4 Role of the Radiographic Examination in the Evaluation of Skeletal Metastases.- 2.5 Summary.- 3 Medical Treatment.- 3 Chemotherapy.- 3.1 Problems of Response Assessment in Skeletal Metastases.- 3.2 Breast Cancer.- 3.3 Lung Cancer.- 3.4 Prostate Cancer.- 3.5 Renal Cell Carcinoma.- 3.6 Summary.- 4 Immunotherapy.- 4.1 Active Non-specific Immunotherapy.- 4.2 Active Specific Immunotherapy.- 4.3 Passive Immunotherapy.- 4.4 Interferons.- 4.5 Interleukin-2.- 4.6 Conclusion.- 5 Biphosphonates.- 5.1 Mechanism of Action.- 5.2 Bone Pain.- 5.3 Osteolytic Process.- 5.4 Prevention of Complications of Bone Metastases in Patients with Breast Cancer.- 5.5 Prevention of Bone Metastases Development in Patients with Breast Cancer.- 5.6 Summary.- 6 Hormonal Therapy.- 6.1 Introduction.- 6.2 Breast Cancer.- 6.3 Prostate Cancer.- 6.4 Endometrial Cancer.- 7 Cement-Containing Antimitotics.- 7.1 Study of the Release of Methotrexate.- 7.2 Study of the Release of Cisplatin.- 7.3 Diffusion Mechanism of Antimitotics.- 7.4 Clinical Experience.- 7.5 Conclusion.- 4 Radiotherapy.- 8 Radiotherapy in the Treatment of Bone Metastases.- 8.1 Introduction.- 8.2 External Radiotherapy.- 8.3 Systemic Radiotherapy.- 8.4 Summary.- 9 Radiosurgical Treatment of Bone Metastasis of the Limbs.- 9.1 Introduction.- 9.2 Patients.- 9.3 Methods.- 9.4 Results.- 9.5 Discussion.- 9.6 Conclusion.- 5 Surgical Treatment.- 10 Surgery for Bone Metastasis of the Limbs.- 10.1 Introduction.- 10.2 Clinical Bases.- 10.3 Principles of Palliative Surgery for Bone Metastasis.- 10.4 Methods.- 10.5 Discussion.- 10.6 Conclusion.- 11 Surgical Treatment of Vertebral Metastases.- 11.1 Therapeutic Decision.- 11.2 Surgical Techniques.- 11.3 Results.- 11.4 Conclusion.- 12 Treatment of Secondary Spinal Tumours.- 12.1 Introduction.- 12.2 Consideration of the Primary Tumour.- 12.3 Surgery.- 12.4 Vertebroplasty.- 12.5 Conclusion.- 6 Medico-social Aspects.- 13 Caring for Cancer Patients.- 13.1 Introduction.- 13.2 Life, Birth and Death.- 13.3 Tridimensional Reality of Human Beings.- 13.4 What is Suffering?.- 13.5 Caring for Suffering People.- 13.6 Conclusion.- 7 Pain Relief.- 14 Therapeutic Approaches to Bone Cancer Pain.- 14.1 Introduction.- 14.2 Bone Metastases and Pain.- 14.3 Management of Bone Pain.- 14.4 Conclusion.- Conclusion.
Klappentext
An introductory text on bone metastases written by experts from various disciplines. It covers the basic principles of surgery in bone cancer, classification, medical treatment, radiotherapy, surgical treatment, incidence and pain relief. The steady progress in diagnosis and treatment of bone cancer in the last decade has dramatically changed the prognosis of cancer patients, improving significantly the overall survival rate and quality of life. Multidisciplinary treatments that combine surgery, radiotherapy and chemotherapy, as described in this book, show significantly improved results and an above average survival rate. Some hematologic malignancies that involve bone may be cured with systemic chemotherapy or radiotherapy, but for most patients with bone metastases, pain relief is the goal of therapy.
This title is an introductory text to bone metastases for orthopaedic surgeons. . It covers the basic principles of surgery in bone cancer; classification; medical treatment; radiotherapy; surgical treatment, incidence and pain relief. Bone metastases are a common cause of morbidity in cancer patients. The debilitating pain that occurs in many patients with advanced malignancies is primarily produced by bone metastases. While almost every malignancy can cause bone metastases, breast cancer, lung cancer, and prostate cancer account for more than 80% of bone metastases. Some hematologic malignancies that involve bone may be cured with systemic chemotherapy or radiotherapy, but for most patients with bone metastases, pain relief is the goal of therapy.
