Understanding the role of hedgehog signaling in cancer is critically important for novel cancer therapeutics. The hedgehog pathway is a major pathway regulating cell differentiation, tissue polarity, stem cell maintenance and cell proliferation. It is known by now that activation of this pathway occurs in a variety of human cancer, including basal cell carcinomas (BCCs), medulloblastomas, leukemia, gastrointestinal, lung, ovarian, breast and prostate cancers. This book provides insightful views suitable for graduate students, medical students, undergraduate students, basic and clinical scientists, cancer patients as well as the general public.
Presents up-to-date information in this exciting research area
Summarizes major advances made on hedgehog signaling mechanisms, activation of the pathway in various human cancer types
Highlights current challenges in our efforts to translate the basic biology into clinic
Provides insightful views suitable for graduate, undergraduate, and medical students, basic and clinical scientists, cancer patients as well as the general public