THE ADHESION GPCRs; GENE REPERTOI RE, PHYLOGENY AND EVOLUTION.- 7tm?CADHERINS: Developmental Roles and Future Challenges.- LATROPHILIN SIGNALLING IN TISUE POLARITY AND MORPHOGENESIS.- GPS Proteolytic Cleavage of Adhesion?GPCRs.- THE LATROPHILINS, "SPLIT?PERSONALITY" RECEPTORS.- Studies on the Very Large G Protein?Coupled Receptor: From Initial Discovery to Determining Its Role in Sensorineural Deafness in Higher Animals.- Adhesion?GPCRs in the CNS.- GPR56 Interacts withExtracellular Matrix and Regulates Cancer Progression.- Adhesion?GPCRs in Tumorigenesis.- Immunity and adhesion?GPCRs.- CD97 IN LEUKOCYTE TRAFFICKING.- THE ROLE OF CD97 IN REGULATING ADAPTIVE T?CEL RESPONSES.- F4/80: The Macrophage?Specific Adhesion?GPCR and Its Role in Immunoregulation.- Signal transduction mediated through adhesion?GPCRs.- EMERGING ROLES OF BRAIN?SPECIFIC ANGIOGENESIS INHIBITOR 1.- Appendix: Mammalian
The field of adhesion-GPCR biology has indeed become large enough to require a volume dedicated solely to this field. The contributors to this book have made a courageous effort to address the key concepts of adhesion-GPCR biology, including the evolution and biochemistry of adhesion-GPCRs; there are extensive discussions on the functional nature of these receptors during development, the immune response and tumourgenesis. Finally, there are chapters dedicated to adhesion-GPCR signalling, an area of intense investigation. This volume focuses on the recent advances in adhesion-GPCR biology.
Includes evolution of the adhesion-GPCR genes in several species
Explores how this proteolytic cleavage was identified as an intrinsic protein modification process in the majority adhesion-GPCRs
Describes the expression of adhesion-GPCRs within the male reproductive tract and reviews their potential contribution in reproductive competence