Radiation Effects on the Blood-Forming System.- The Small Intestine as a Target for Radiation.- Radiation and Humoral Immunity.- Modeling of Autoimmune Processes.- Individual-Based Approach to Radiation Risk Assessment.
Themonographisdevotedtothetheoreticalstudiesofradiationeffectsonmammals. It summarizes the results obtained by the author over the past 30 years, most of them being of high priority. In the course of these studies, a single approach to the modeling of radiation effects on mammals has been elaborated. Speci?cally, in the framework of the developed deterministic mathematical models, the effects of both acute and chronic irradiation in a wide range of doses and dose rates on vital body systems (hematopoiesis, small intestine, and humoral immunity), as well as on the development of autoimmune diseases, are investigated. The radiation effects on the mortality dynamics in homogeneous and nonhomogeneous(in radiosensitivity) mammalian populations are also studied by making use of the developed stochastic models. The most appealing feature of these mortality models consists of the fact that they account for the intrinsic properties of the exposed organism. Namely, within these models the stochastic biometrical functions are calculated proceeding from statistical characteristics and dynamics of the respective critical body system (hematopoiesis or small intestine). The performed theoretical investigations contribute to the development of the system and quantitative approaches in radiation biology and ecology. These studies elucidate the major regulatory mechanisms of the damage and recovery processes running in the vital body systems of exposed mammals and reveal the key par- eters characterizing the processes.
Wide ranging study of fundamental problems in radiation biology (namely, acute/chronic effects of irradiation from exposure such as in the space environment on vital body systems, on whole organisms, and on mammalian populations) using mathematical modeling
Wide practical use in radiation risk assessment by space agencies and aerospace companies, among others
Can be used as a basis for a lecture course on mathematical modeling in radiation biology and ecology