This book brings together reviews from experts who study mechanisms and signaling pathways that regulate development of squamous cancer in a variety of tissue sites, in both human and experimental mouse models, and to focus on how these specific signaling pathways can be utilized as targets for anti-cancer therapy.
This book brings together reviews from experts who study mechanisms and signaling pathways that regulate development of squamous cancer in a variety of tissue sites, in both human and experimental mouse models, and to focus on how these specific signaling pathways can be utilized as targets for anti-cancer therapy.
Includes supplementary material: sn.pub/extras
Squamous epithelia form the lining surface of tissues in contact with the environment: the skin, oral mucosa, esophagus and respiratory tract, the genital tract, and several other specialized tissues. These tissues are at highest risk for exposure to environmental carcinogens such as UV, tobacco smoke and infectious agents. Cancers that form in squamous epithelia are among the most common human solid tumors and have high morbidity and mortality. These cancers include squamous cell carcinoma of the skin, oral cancer, head and neck and esophageal cancer, certain lung cancers and cervical cancer.
We propose to organize the book so that the early chapters will focus on individual pathways and more specific mechanisms in both normal function and cancer, while the later chapters will be more integrative and include overviews of biomarkers and therapeutic development. This should increase interest for clinically oriented researchers. All authors will be encouraged to provide a balanced review in addition to highlighting their own work.
Signaling Pathways in Squamous CancerChapter 1. Cell Adhesion Molecules in Carcinoma Invasion and MetastasisZiober, Humtsoe and KramerChapter 2. Roles of Integrins in the Development and Progressio of Squamous Cell CarcinomaLamar and DiPersioChapter 3. Alterations in Transforming Growth Factor beta Signaling in Squamous Cell CarcinomasXie and RiessChapter 4. Aberrant Activation of HGF/c-MET Signalign and Targeted Therapy in Squamous CancerChenChapter 5. The Epidermal Growth Factor Receptor in normal and Neoplastic EpitheliaRepertinger, Madson, Bischel and HansenChapter 6. Cyclooxygenase-2 Signaling in Squamous Cell CancerRundhaug and FischerChapter 7. Interacting Signaling Pathways in Mouse Skin Tumor Initiation and ProgressionCataisson and YuspaChapter 8. Protein Kinase C and the Development of Squamous Cell CarcinomaDenningChapter 9. The Tranillegalscription factor AP-1 in Squamous Cell Carcinogenesis: Lessons From Mouse Models of Skin CarcinogenesisHess and AngelChapter 10. NF-kB and IkB Kinases in Squamous CancersCostanzo, Spallone and KarinChapter 11. Regulation of Squamous Cell Carcinoma Carcinogenesis by Peroxisome Proliferator-Activated Receptors (PPARs)Peters and GonzalezChapter 12. p63 in Squamous Differentiation and CancerRoop and KosterChapter 13. Effects of Natural and Synthetic Retinoids on the Differnetiation and Growth of Squamous CancersKadara and LotanChapter 14. Regulation of Keratinocyte Differnetiation by Vitamin D and its Relationship to Squamous Cell CarcinomaTeichert and BickleChapter 15. Epidermal Growth Factor Receptor-Targeted TherapiesAhn, Kin and GrandisChapter 16. Targeting UVB Mediated Signal Transduction Pathways for the Chemoprevention of Squamous Cell CarcinomaBowden and AlbertsChapter 17. Molecular Targeted Chemotherapy for Head and Neck Squamous Cell CarcinomaLin and RoccoChapter 18. Effects and Therapeutic Potential of Targeting Dysregulated Signaling Axes in Squamous Cell Carcinoma:AKT and MTORClark, Ekshyyan and NathanChapter 19. Head and Neck Cancer and the PI3K/AKT/mTOR Signaling Network: Novel Moleuclar Targeted TherapiesAmornphimoltham, Patel, Molinolo and GutkindChapter 20. High Throughput Molecular Profiling Approaches for the Identification of Genomic Alterations and Therapeutic TargetsZhou, Hu and Wong
Squamous epithelia form the essential lining surface of tissues in contact with the environment, including the skin, and mucosa of the oral cavity, pharynx, larynx, esophagus, respiratory and genital tracts, and several other specialized tissues. These tissues are at highest risk for exposure to environmental carcinogens such as UV light, tobacco smoke, and infectious agents. Consequently, squamous cell carcinomas that form in these tissues are among the most common human solid tumors, and have high morbidity and mortality. The signaling pathways that regulate epithelial homeostasis and the alterations in these pathways that arise during cancer development share certain features among these different tissue sites. This book brings together timely reviews from experts in the field on mechanisms and signaling pathways such as EGFR, TGF?1, NF?B, PPARs and mTOR/AKT that regulate development of squamous cancer in both human and experimental mouse models, with a focus on how these specific signaling pathways can be utilized as targets for anti-cancer therapy. This comprehensive monograph will be important for researchers wishing to enter the field, for medical students, and for established basic and clinical investigators who would gain from an overview of the field.
This book reviews studies of mechanisms and signaling pathways that regulate development of squamous cancer in a variety of tissue sites. There is focus on how these specific signaling pathways can be utilized as targets for anti-cancer therapy.
Signaling Pathways in Squamous CancerChapter 1. Cell Adhesion Molecules in Carcinoma Invasion and MetastasisZiober, Humtsoe and KramerChapter 2. Roles of Integrins in the Development and Progressio of Squamous Cell CarcinomaLamar and DiPersioChapter 3. Alterations in Transforming Growth Factor beta Signaling in Squamous Cell CarcinomasXie and RiessChapter 4. Aberrant Activation of HGF/c-MET Signalign and Targeted Therapy in Squamous CancerChenChapter 5. The Epidermal Growth Factor Receptor in normal and Neoplastic EpitheliaRepertinger, Madson, Bischel and HansenChapter 6. Cyclooxygenase-2 Signaling in Squamous Cell CancerRundhaug and FischerChapter 7. Interacting Signaling Pathways in Mouse Skin Tumor Initiation and ProgressionCataisson and YuspaChapter 8. Protein Kinase C and the Development of Squamous Cell CarcinomaDenningChapter 9. The Tranillegalscription factor AP-1 in Squamous Cell Carcinogenesis: Lessons From Mouse Models of Skin CarcinogenesisHess and AngelChapter 10. NF-kB and IkB Kinases in Squamous CancersCostanzo, Spallone and KarinChapter 11. Regulation of Squamous Cell Carcinoma Carcinogenesis by Peroxisome Proliferator-Activated Receptors (PPARs)Peters and GonzalezChapter 12. p63 in Squamous Differentiation and CancerRoop and KosterChapter 13. Effects of Natural and Synthetic Retinoids on the Differnetiation and Growth of Squamous CancersKadara and LotanChapter 14. Regulation of Keratinocyte Differnetiation by Vitamin D and its Relationship to Squamous Cell CarcinomaTeichert and BickleChapter 15. Epidermal Growth Factor Receptor-Targeted TherapiesAhn, Kin and GrandisChapter 16. Targeting UVB Mediated Signal Transduction Pathways for the Chemoprevention of Squamous Cell CarcinomaBowden and AlbertsChapter 17. Molecular Targeted Chemotherapy for Head and Neck Squamous Cell CarcinomaLin and RoccoChapter 18. Effects and Therapeutic Potential of Targeting Dysregulated Signaling Axes in Squamous Cell Carcinoma:AKT and MTORClark, Ekshyyan and NathanChapter 19. Head and Neck Cancer and the PI3K/AKT/mTOR Signaling Network: Novel Moleuclar Targeted TherapiesAmornphimoltham, Patel, Molinolo and GutkindChapter 20. High Throughput Molecular Profiling Approaches for the Identification of Genomic Alterations and Therapeutic TargetsZhou, Hu and Wong
Inhaltsverzeichnis
Signaling Pathways in Squamous Cancer
Chapter 1. Cell Adhesion Molecules in Carcinoma Invasion and Metastasis
Ziober, Humtsoe and Kramer
Chapter 2. Roles of Integrins in the Development and Progressio of Squamous Cell Carcinoma
Lamar and DiPersio
Chapter 3. Alterations in Transforming Growth Factor beta Signaling in Squamous Cell Carcinomas
Xie and Riess
Chapter 4. Aberrant Activation of HGF/c-MET Signalign and Targeted Therapy in Squamous Cancer
Chen
Chapter 5. The Epidermal Growth Factor Receptor in normal and Neoplastic Epithelia
Repertinger, Madson, Bischel and Hansen
Chapter 6. Cyclooxygenase-2 Signaling in Squamous Cell Cancer
Rundhaug and Fischer
Chapter 7. Interacting Signaling Pathways in Mouse Skin Tumor Initiation and Progression
Cataisson and Yuspa
Chapter 8. Protein Kinase C and the Development of Squamous Cell Carcinoma
Denning
Chapter 9. The Tranillegalscription factor AP-1 in Squamous Cell Carcinogenesis: Lessons From Mouse Models of Skin Carcinogenesis
Hess and Angel
Chapter 10. NF-kB and IkB Kinases in Squamous Cancers
Costanzo, Spallone and Karin
Chapter 11. Regulation of Squamous Cell Carcinoma Carcinogenesis by Peroxisome Proliferator-Activated Receptors (PPARs)
Peters and Gonzalez
Chapter 12. p63 in Squamous Differentiation and Cancer
Roop and Koster
Chapter 13. Effects of Natural and Synthetic Retinoids on the Differnetiation and Growth of Squamous Cancers
Kadara and Lotan
Chapter 14. Regulation of Keratinocyte Differnetiation by Vitamin D and its Relationship to Squamous Cell Carcinoma
Teichert and Bickle
Chapter 15. Epidermal Growth Factor Receptor-Targeted Therapies
Ahn, Kin and Grandis
Chapter 16. Targeting UVB Mediated Signal Transduction Pathways for the Chemoprevention of Squamous Cell Carcinoma
Bowden and Alberts
Chapter 17. Molecular Targeted Chemotherapy for Head and Neck Squamous Cell Carcinoma
Lin and Rocco
Chapter 18. Effects and Therapeutic Potential of Targeting Dysregulated Signaling Axes in Squamous Cell Carcinoma:AKT and MTOR
Clark, Ekshyyan and Nathan
Chapter 19. Head and Neck Cancer and the PI3K/AKT/mTOR Signaling Network: Novel Moleuclar Targeted Therapies
Amornphimoltham, Patel, Molinolo and Gutkind
Chapter 20. High Throughput Molecular Profiling Approaches for the Identification of Genomic Alterations and Therapeutic Targets
Zhou, Hu and Wong
Klappentext
Squamous epithelia form the lining surface of tissues in contact with the environment: the skin, oral mucosa, esophagus and respiratory tract, the genital tract, and several other specialized tissues. These tissues are at highest risk for exposure to environmental carcinogens such as UV, tobacco smoke and infectious agents. Cancers that form in squamous epithelia are among the most common human solid tumors and have high morbidity and mortality. These cancers include squamous cell carcinoma of the skin, oral cancer, head and neck and esophageal cancer, certain lung cancers and cervical cancer.
We propose to organize the book so that the early chapters will focus on individual pathways and more specific mechanisms in both normal function and cancer, while the later chapters will be more integrative and include overviews of biomarkers and therapeutic development. This should increase interest for clinically oriented researchers. All authors will be encouraged to provide a balanced review in addition to highlighting their own work.
This book brings together reviews from experts who study mechanisms and signaling pathways that regulate development of squamous cancer in a variety of tissue sites, in both human and experimental mouse models, and to focus on how these specific signaling pathways can be utilized as targets for anti-cancer therapy.
Includes supplementary material: sn.pub/extras
