Introduction,- Protein Folding and Molecular Chaperones.- Transport of Proteins and Vesicles to the Synapse.- Protein Synthesis, Folding and Degradation in the Synaptic Compartment.- Synaptic Protein Interactions/Reguatlion by Molecular Chaperones.- Folding/Misfolding and Synaptic Dysfunction During Chronic Neurodegeration.
Folding for the Synapse addresses the current view on how protein folding and misfolding, controlled by molecular chaperones, contribute to synapse function and dysfunction. Molecular chaperones have been studied in relation to de novo protein folding, but there is increasing awareness that chaperone function is required for the regulation of protein dynamics when functioning physiologically as an isolated moiety or part of a protein complex. This book will introduce both important concepts of folding machineries and give examples of the biological relevance of further chaperone functions.
Introduces important concepts of folding machineries.
Gives examples of the biological relevance of further chaperone functions.
Addresses the current view on how protein folding and misfolding contribute to synapse function and dysfunction.