The basic goal of this new text is to introduce students to molecular modeling and simulation and to the wide range of biomolecular problems being attacked by computational techniques. The premise of the author is that the dazzling modeling and simulation software now available often leaves practitioners unaware of the fundamental problems and the complex algorithmic approaches to them that still form the heart of ongoing research. The text provides an overview of biomolecular modeling and structure, molecular mechanics (including functional construction and evaluation techniques), molecular graphics and visualization, techniques for conformational sampling (Monte Carlo, global optimization), methods for geometry optimization, and molecular dynamics simulations. Throughout the text emphasizes that the field changes very rapidly and that it is full of exciting discoveries, and that many of these findings lead to medical and technological breakthroughs. This book stimulates this e xcitement, while still providing students many computational details. The text evolved from Molecular Modeling courses taught by the author at New York University. It contains detailed illustrations throughout and homework assignments at the end of the book. It should appeal to beginning graduate students in medical schools, and in many scientific departments such as biology, chemistry, physics, mathematics and computer science.
From the reviews:
HAROLD A. SCHERAGA, CORNELL UNIVERSITY"The interdisciplinary structural biology community has waited long for a book of this kind which provides an excellent introduction to molecular modeling."J. ANDREW McCAMMON, HOWARD HUGHES MEDICAL INSTITUTE, UNIVERSITY OF CALIFORNIA AT SAN DIEGO"A uniquely valuable introduction to the modeling of biomolecular structure and dynamics. A rigorous and up-to-date treatment of the foundations, enlivened by engaging anecdotes and historical notes."J.J. COLLINS, BOSTON UNIVERSITY"I am often asked by physicists, mathematicians and engineers to recommend a book that would be useful to get them started in computational molecular biology. I am also often approached by my colleagues in computational biology to recommend a solid textbook for a graduate course in the area. Tamar Schlick has written the book that I will be recommending to both groups. Tamar has done an amazing job in writing a book that is both suitably accessible for beginners, and suitably rigorous for experts."BIOINFORMATICS"It is a fantastic graduate textbook to get into structural biology. The 14 chapters offer keys to understand the broader context of this field and the impact it can have on our everyday life for example through medical applications...The main achievement of the book is that even the most sophisticated problems are part of a gradual approach...certainly efficient...The book will obviously be of great interest to students and teachers but it should also be very valuable for research scientists, especially newcomers to the field of molecular modeling, as a reference book and a point of entry in the more specialized literature."BIOTECH INTERNATIONAL [BTI]:" . . . The text emphasises that the field is changing very rapidly and that it is full of exciting discoveries. Many of these findings have lead to medical and technological breakthroughs. This book stimulates this excitement, while still providing students many computational details . . . It should appeal to beginning graduate students in medical schools, and in many scientific departments such as biology, chemistry, physics, mathematics, and computer science.
Review by Henry van den Bedem, University of Alabama-Birmingham"The book is unique in that it combines introductory molecular biology with advanced topics in modern simulation algorithms in no more than 600 pages. ... For those seeking more detail, the author provides 1000+ references, and additionally includes reading lists complementing the main text. This is an excellent introductory text that is a pleasure to read."ZENTRALBLATT MATH
Review by Ivan Krivy, University of Ostrava, Czech Republic"This book provides an excellent introduction to the modeling of biomolecular structures and dynamics. It is subdivided into three parts covering relatively broad topics: (1) molecular structure and modeling, inclusive of current problems and state of computation (Chapters 1-6); (2) molecular mechanics: force field origin, composition, and evaluation techniques (Chapters 7-9); and (3) simulation techniques: conformational sampling by geometry optimization, Monte Carlo, and molecular dynamics approaches (Chapter 10-13). The last chapter (Chapter 14) is devoted to discussing the similarity and diversity problems in chemical design. The book's appendices complement the material in the main text through homework assignments, reading lists, and other information useful for teaching molecular modeling.\par The book is intended for students of an interdisciplinary graduate course in molecular modeling as well as for researchers (physicists, mathematicians and engineers) to get them started in computational molecular biology.""Molecular modeling ... is now an important branch of modern biochemistry. ... Schlick has brought her unique interdisciplinary expertise to the subject. ... One of the most distinguished characteristics of the book is that it makes
Biomolecular Structure and Modeling: Historical Perspective.- Biomolecular Structure and Modeling: Problem and Application Perspective.- Protein Structure Introduction.- Protein Structure Hierarchy.- Nucleic Acids Structure Minitutorial.- Topics in Nucleic Acids Structure.- Theoretical and Computational Approaches to Biomolecular Structure.- Force Fields.- Nonbonded Computations.- Multivariate Minimization in Computational Chemistry.- Monte Carlo Techniques.- Molecular Dynamics: Basics.- Molecular Dynamics: Further Topics.- Similarity and Diversity in Chemical Design.- Epilogue.- Appendices.- Index.
Very broad overview of the field intended for an interdisciplinary audience; Lively discussion of current challenges written in a colloquial style; Author is a rising star in this discipline; Suitably accessible for beginners and suitably rigorous for experts; Features extensive four-color illustrations; Appendices featuring homework assignments and reading lists complement the material in the main text