Preface.- Section I. Introduction to A Post-Genomic View of Aging and the Aging Heart: Post-Genomic View of Aging: Definitions, Theories and Observations.- Overview of Cardiovascular Aging.- Section II. Methodologies, Cardiac Phenotypes And Adaptation: Molecular and Cellular Methodologies.- Molecular And Cellular Phenotypes of Cardiac Aging.- Section III. Aging of the Cardiovasculature and Related Systems: Aging of the Vasculature.- Aging of Cardiovascular-Related Systems.- Section IV. Cardiovascular Diseases in Aging: Cardiomyopathy and Heart Failure in Aging.- Atherosclerosis, Hypertension and Aging.- Metabolic Syndrome, Diabetes and Cardiometabolic Risks in Aging.- Gender and Cardiovascular Aging.- Cardiac Dysrhythmias and Channelopathies in Aging.- Section V. Genetics: Genetics of Life Span: Lessons from Model Organisms.- Profiling the Aging Cardiovascular System: Transcriptional, Proteomic, SNP, Gene Mapping and Epigenetics Analysis.- Section VI. Therapies: Translational Research: Pharmacogenomics, Gene and Cell-Based Therapy in the Aging Cardiovascular System.- Nutrition and Exercise in Cardiovascular Aging: Metabolic and Pharmacological Interventions.- Section VII. The Future of Aging Research: Aging and the Frontier ahead.- Glossary.- Index.
In this book, the genetic and molecular basis of cardiovascular aging is examined in detail and a comprehensive assessment given of the bioenergetics changes occurring in human and animal models of cardiac aging. Both current diagnostic and future therapeutic modalities are presented, giving this book a dual-pronged approach. Cardiac aging, like aging in general, is a complex process involving numerous cellular and molecular changes. This book sheds new light on the phenomenon.
Cardiac aging, like aging in general, is a complex process. Numerous cellular and molecular changes contribute to the expression of the multiple phenotypes of aging, "the different faces" of cardiac aging. In this book, the genetic and molecular basis of cardiovascular aging is discussed. The work has been enabled by the availability of the Human Genome Project, and an ever increasing number of animal models as well as new and exciting molecular technologies. It can now be genuinely stated that the unraveling of the underlying basic mechanisms of cardiac aging have begun. The book also includes a comprehensive assessment of the bioenergetic changes that occur in human and animal models of cardiac aging as well as current diagnostic and future therapeutic modalities are undertaken.