Introduction To Biopharmaceutics And Its Role In Drug Development.- Molecular and Physicochemical Properties Impacting Oral Absorption of Drugs.- Dissolution Testing.- Drug Absorption Principles.- Current Industrial Practices of Evaluating Permeability/Absorption and P-glycoprotein Interaction.- Excipients As Absorption Enhancers.- Intestinal Transporters In Drug Absorption.- Bioavailability And Bioequivalence.- A Biopharmaceutical Classification System Approach to Dissolution: Mechanisms and Strategies.- Food Effects On Drug Bioavailability: Implications For New And Generic Drug Development.- In Vitro-In Vivo Correlation on Parenteral Dosage Forms.- In Vitro-In Vivo Correlation in Dosage Form Development: Case Studies.- Index.
The highly experienced authors here present readers with step-wise, detail-conscious information to develop quality pharmaceuticals. The book is made up of carefully crafted sections introducing key concepts and advances in the areas of dissolution, BA/BE, BCS, IVIC, and product quality. It provides a specific focus on the integration of regulatory considerations and includes case histories highlighting the biopharmaceutics strategies adopted in development of successful drugs.
discusses state of the art knowledge in biopharmaceutics
identifies key issues and opportunities in a distinct problem-solving approach