Section I Anatomical Studies of the Monoaminergic System: The Discovery of Multiple Serotonin Receptor Subtypes: A Lesson from Molecular Cloning to Functional Expression.- Distribution of D1-like and D2 Receptors in the Monkey Brain: Implications for Cognitive function in Schizophrenia.- Anatomical Characteristics of Norepinephrine Axons in the Prefrontal Cortex: Unexpected Findings That May Indicate Low Activity State in Naïve Animals.- Section II Monoaminergic Regulation of Cortical Function: Serotonin Modulation of Cortical Activity.- Serotonerigic Regulation of NMDA Receptor Trafficking and Function in Prefrontal Cortex.- Cross-Modulation Between GABAB and 5-HT Receptors: A Link Between Anxiety and Depression?- Serotonin Involvement in Plasticity of the Visual Cortex.- Cellular Mechanisms of Working Memory and its Modulation by Dopamine in the Prefrontal Cortex of Primates and Rats.- Dopamine D1 and Glutamate N-Methyl-D-Aspartate Receptors: An Essential Interplay in Prefrontal Cortex Synaptic Plasticity.- Prefrontal Cortical Synaptic Plasticity: The Roles of Dopamine and Implication for Schizophrenia.- Acquiring the Excitatory and the Inhibitory Action of Dopamine in the Prefrontal Cortex During Postnatal Development.- Dopamine and Noradrenaline Coupling in the Cerebral Cortex.- Regulation of Cortical Functions by the Central Noradrenergic System: Emerging Properties from an Old Friend.- Neuromodulation of Cortical Synaptic Plasticity.- Section III Computational Analyses of Cortical Monoaminergic Function: Dopaminergic Modulation of Prefrontal Cortex Network Dynamics.- Stable and Unstable Activation of the Prefrontal Cortex with Dopaminergic Modulation.- Dopamine and Norepinephrine Modulation of Cortical and Sub-Cortical Dynamics During Visuomotor Learning.- Section IV Monoamines and Psychiatric Disorders: Basal Ganglia - Cortex Interactions: Regulation of Cortical Function by D1 Dopamine Receptors in the Striatum.- Interplay Between Dopamine and Acetylcholine in the Modulation of Attention.- Monoamine-Based Treatments in Schizophrenia: Time to Change the Paradigm?- Prefrontal Cortical Circuits and Schizophrenia Pathophysiology.- Index.
This book provides a comprehensive, integrated comparison of the complex modulatory action of dopamine, noradrenaline, and serotonin receptors in the cortex. The discussion assembles a range of opinions on how the monoamine systems affect cortical function. The complexity of these interactions is discussed in light of recent data showing the dramatic effect of disruption of these systems on memory formation and information processing in the cortex.
Reviews important cellular and synaptic mechanisms by which dopamine, noradrenaline and serotonin receptors regulate cortical excitability and plasticity during critical periods of postnatal development
Discusses and establishes the link between mechanisms coupling these monoamine actions on biophysical properties of cortical neurons and synapses to its potential computational role in cortical functions
Provides new insights on how disruption of these interactions will affect dramatically the memory formation and information processing in the cortex
Will be of interest to a broad audience of neuroscientists from cellular and system physiology to behavior researchers
Can be used as a supplementary text for courses in neuroanatomy, neurophysiology, cellular and molecular pharmacology, pathophysiology of psychiatric disorders, and experimental psychology