Regulation and function of the E2A proteins in B cell development.- Multiple roles for Blimp-1 in B and T lymphocytes.- Memory B cell evolution: B cell biology.- BCR-linked factors in developmental fate decisions.- Gene Regulatory Networks that Orchestrate the Development of B Lymphocyte Precursors.- Rules for the rearrangement events at the L chain gene loci of the mouse.- Regulation of AID function in vivo.- Targeting of AID to immunoglobulin genes.- Targeting AID to the Ig genes.- DNA replication to AID somatic hypermutation.- Regulation of activation-induced deaminase via phosphorylation.- Modulation of MHC class II signal transduction by CD19.- Role of NF-k B signaling in normal and malignant B cell development.- Fc receptor-like proteins (FCRL): Immunomodulators of B cell function.- Tolerance mechanisms in the late phase of the antibody response.- Role of RS/k DE in B cell receptor editing.- The regulation of receptor editing.- B cell hyporesponsiveness and autoimmunity: A new paradigm.
In recent years, major developments have increased understanding of various genetic and epigenetic regulatory processes that are critical for the generation of B cell repertoires. These include the role of chromatin regulation and nuclear organization in understating the IgH gene regulation. These proceedings highlight recent developments in lymphocyte development, Ig gene rearrangements and somatic hypermutation, chromatin structure modification, B lymphocyte signaling and fate, receptor editing, and autoimmunity.
Discusses the latest developments in the area of lymphocyte activation and immune regulation