Principles of Human Tumor Virology.- History of Papillomavirus Research.- Phylogeny and Typing of Papillomaviruses.- The differentiation-dependent life cycle of human papillomaviruses in keratinocytes.- Papillomavirus Structure and Assembly.- Viral Entry and Receptors.- Human Papillomavirus Transcription.- Papillomavirus DNA Replication.- Papillomavirus E5 Proteins.- Human Papillomavirus E6 and E7 Oncogenes.- In Vivo Models for the Study of Animal and Human Papillomaviruses.- The Humoral Immune Response to Human Papillomavirus.- Cell-Mediated Immune Response to Human Papillomavirus.- Papillomavirus Vaccines.- Clinical Assessment, Therapies, New Tests and Algorithms.- Possible Wordwide Impact of Prevention of Human Papillomavirus Infection.
This volume evaluates the carcinogenic risk to humans posed by infection with human papillomaviruses (HPVs). To date, more than 70 HPV types have been identified, of which over 15 have been reported in cervical cancer biopsies. Worldwide, cervical cancer is the second most common cancer in women. This book also considers the possible involvement of HPV infection in cancers at other sites of the human body.
Complete description of the current state of biology concerning the papillomavirus