Viral RNA Synthesis.- The Coronavirus Replicase: Insights into a Sophisticated Enzyme Machinery.- Biochemical Aspects of Coronavirus Replication.- A Previously Unrecognized Unr Stem-Loop Structure in the Coronavirus 5' Untranslated Region Plays a Functional role in Replication.- Regulation of Coronavirus Transcription: Viral and Cellular Proteins Interacting with Transcription-Regulating Sequences.- Deubiquitinating Activity of the SARS-CoV Papain-Like Protease.- Nucleocapsid Protein Expression Facilitates Coronavirus Replication.- Non Structural Proteins 8 and 9 of Human Coronavirus 229E.- Effects of Mutagenesis of Murine Hepatitis Virus NSP1 and NSP14 on Replication in Culture.- Mutational Analysis of MHV-A59 Replicase Protein-NSP10.- The NSP2 Proteins of Mouse Hepatitis Virus and Sars Coronavirus are Dispensable for Viral Replication.- Molecular Dissection of Porcine Reproductive and Respiratory Virus Putative Nonstructural Protein 2.- Differential role of N-Terminal Polyprotein Processing in Coronavirus Genome Replication and Minigenome Amplification.- Identification and Characterization of Severe Acute Respiratory Syndrome Coronavirus Subgenomic RNAs.- Identification and Characterization of a Unique Ribosomal Frameshifting Signal in SARS-CoV ORF3A.- Adp-Ribose-1"-Phosphatase Activities of the Human Coronavirus 229E and Sars Coronavirus X Domains.- Nonstructural Proteins of Human Coronavirus NL63.- MHV-A59 Orf1a Replicase Protein NSP7-NSP10 Processing in Replication.- Stem-Loop 1 in the 5' UTR of the Sars Coronavirus can Substitute for its Counterpart in Mouse Hepatitis Virus.- Transcriptional Regulation of RNA3 of Infectious Bronchitis Virus.- Protein Synthesis, Structure, and Processing.- Structure, Expression, and Intracellular Localization of the SARS-CoV Accessory Proteins 7a and 7b.- Sumoylation of the Nucleocapsid Protein of Severe Acute Respiratory Syndrome Coronavirus by Interaction with UBC9.- Importance of MHV-CoV A59 Nucleocapsid Protein Cooh-Terminal Negative Charges.- Expression and Structural Analysis of Infectious Bronchitis Virus Nucleoprotein.- Mouse Hepatitis Virus Infection Activates the IRE1/XBP1 Pathway of the Unfolded Protein Response.- The Nuclear Localization Signal of the Prrs Virus Nucleocapsid Protein Modulates Viral Replication in vitro and Antibody Response in vivo.- Sars Coronavirus Accessory ORFs Encode Luxury Functions.- Production and Characterization of Monoclonal Antibodies Against the Nucleocapsid Protein of SARS-COV.- Mouse Hepatitis Coronavirus Nucleocapsid Phosphorylation.- Viral Assembly and Release.- Genetic and Molecular Biological Analysis of Protein-Protein Interactions in Coronavirus Assembly.- New Insights on the Structure and Morphogenesis of Berne Virus.- Ultrastructure of SARS-CoV, FIPV, and MHV Revealed by Electron Cryomicroscopy.- Role of Mouse Hepatitis Coronavirus Envelope Protein Transmembrane Domain.- The Transmembrane Domain of the Infectious Bronchitis Virus E Protein is Required for Efficient Virus Release.- Viroporin Activity of SARS-CoV E Protein.- Efficient Transduction of Dendritic Cells Using Coronavirus-Based Vectors.- Viral Entry.- Insights from the Association of SARS-CoV S-Protein with its Receptor, ACE2.- Attachment Factor and Receptor Engagement of Sars Coronavirus and Human Coronavirus NL63.- Interactions Between Sars Coronavirus and its Receptor.- Proteolysis of Sars-Associated Coronavirus Spike Glycoprotein.- Fluorescence Dequenching Assays of Coronavirus Fusion.- Porcine Arterivirus Entry in Macrophages: Heparan Sulfate - Mediated Attachment, Sialoadhesin-Mediated Internalization, and a Cell-Specific Factor Mediating Virus Disassembly and Genome Release.- Enhancement of SARS-CoV Infection by Proteases.- Increased Viral Titers and Subtle Changes in Plaque Morphology Upon Passage of SARS-CoV in Cells from Different Species.- Human Coronavirus 229E can Use CD209L (L-Sign) to Enter Cells.- Intracellular Transport of the S Proteins of Coronaviruses.-
Preface.- Protein Synthesis, Structure, and Processing.- Viral Assembly and Release.- Viral Entry 1 and 2.- Pathogenesis of Non-Human Coronaviruses.- Pathogenesis of Arteriviruses and Toroviruses.- Pathogenesis of Human Coronaviruses.- Vaccines, Anti-Viral Drugs, and Diagnostics.- Index.
This volume is based on the 10th International Nidovirus Symposium: Towards Control of SARS and other Nidovirus Diseases. The volume includes articles by all of the major contributors to this burgeoning area of research which summarize the work presented at the meeting.
This represents the only comprehensive book to cover this field in the last five years.
Summarizes all of the most current research in the field
The only comprehensive book covering in the field in the last 5 years