Less than twenty years ago photolithography and medicine were total strangers to one another. They had not yet met, and not even looking each other up in the classi?eds. And then, nucleic acid chips, micro?uidics and microarrays entered the scene, and rapidly these strangers became indispensable partners in biomedicine. Asrecentlyastenyearsagothenotionofapplyingnanotechnologytothe?ghtagainstd- ease was dominantly the province of the ?ction writers. Thoughts of nanoparticle-vehicled deliveryoftherapeuticalstodiseasedsiteswereanexerciseinscienti?csolitude,andgrounds for questioning one s ability to think like an established scientist . And today we have nanoparticulate paclitaxel as the prime option against metastatic breast cancer, proteomic pro?lingdiagnostictoolsbasedontargetsurfacenanotexturing,nanoparticlecontrastagents for all radiological modalities, nanotechnologies embedded in high-distribution laboratory equipment, and no less than 152 novel nanomedical entities in the regulatory pipeline in the US alone. Thisisatransformingimpact,byanymeasure,withclearevidenceoffurtheracceleration, supported by very vigorous investments by the public and private sectors throughout the world. Even joining the dots in a most conservative, linear fashion, it is easy to envision scenarios of personalized medicine such as the following: patient-speci?c prevention supplanting gross, faceless intervention strategies; early detection protocols identifying signs of developing disease at the time when the disease is most easily subdued; personally tailored intervention strategies that are so routinely and inexpensively realized, that access to them can be secured by everyone; technologies allowing for long lives in the company of disease, as good neighbors, without impairment of the quality of life itself.
Part I Cell-based Therapeutics .- Neural regeneration.- Three dimensional hydrogel photopatterning.- Self- Assembled Peptides for tissue engineering.- Advanced bioassays for analysis of cell function.- Multicellular Biochips for Sensing.- Microelectromechanical systems and neurosurgery.- Part II Drug delivery.- Nanoporous polymer replicas for sensing drug delivery.- Nanoporous inorganic biocapsules.- Ultrasonic drug delivery.- Bioadhesive microsystems for oral drug delivery.- Targeting nanostructures.- Quantum Dot Technology.- Nanoshells for Drug Delivery.- Oncological Nanosystems.- Part III Molecular Surface Engineering for the Biological Interface .- Controlling cell-cell and cell-surface interactions.- Molecular surface engineering.- Life on a chip: Microfluidic cell culture tools for cell biology studies.- Bioresponsive surfaces.- Supported lipid bilayers as mimics for cell surfaces and as tools in biotechnology.
Über den Autor
Dr. Tejal Desai is currently an Associate Professor of Physiology and Bioengineering at the University of California, San Francisco. She is also a member of the California Institute for Quantitative Biomedical Research and the UCSF/UCB Bioengineering Graduate Group. Prior to joining UCSF, she was a professor of Biomedical Engineering at Boston University and Associate Director of the Center for Nanoscience and Nanobiotechnology at BU. She received the Sc.B. degree in Biomedical Engineering from Brown University (Providence, RI) in 1994 and the Ph.D. degree in bioengineering from the joint graduate program at University of California, Berkeley and the University of California, San Francisco, in 1998. Dr. Tejal Desai directs the Laboratory of Therapeutic Micro and Nanotechnology. In addition to authoring over 60 technical papers, she is presently an associate editor of Langmuir, Biomedical Microdevices, and Sensors Letters and is editing a book on Therapeutic Microtechnology. She has chaired and organized several conferences and symposia in the area of bioMEMS, micro and nanofabricated biomaterials, and micro/nanoscale tissue engineering.
Desai's research efforts have earned her numerous awards. In 1999, she was recognized by Crain's Chicago Business magazine with their annual "40 Under 40" award for leadership. She was also named that year by Technology Review Magazine as one of the nation's "Top 100 Young Innovators" and Popular Science's Brilliant 10. Desai's teaching efforts were recognized when she won the College of Engineering Best Advisor/Teacher Award. She also won the National Science Foundation's "New Century Scholar" award and the NSF Faculty Early Career Development Program "CAREER" award, which recognizes teacher-scholars most likely to become the academic leaders of the 21st century. Her research in therapeutic microtechnology has also earned her the Visionary Science Award from the International Society of BioMEMS and Nanotechnology in 2001, a World Technology Award Finalist in 2004, and the EURAND award for innovative advances in drug delivery.
Sangeeta N. Bhatia, M.D., Ph.D., is an Associate Professor at the Massachusetts Institute of Technology. Her work focuses on using micro- and nanotechnology tools to repair damaged tissues. Dr. Bhatia trained at Brown, MIT, and Harvard. After postdoctoral training at the Massachusetts General Hospital , she was a member of the Bioengineering Department at University of California at San Diego for 6 years. In 2005, she returned to Boston to join the MIT faculty. She has been awarded the David and Lucile Packard Fellowship given to 'the nation's most promising young professors in science and engineering,' the MIT TR100 Young Innovators Award, and been named one of San Diego 's '50 People to Watch in 2004'. Her research portfolio includes funding from NIH, NSF, DARPA, NASA, the Whitaker Foundation, the Packard Foundation, and private industry. She co-authored the first undergraduate textbook on tissue engineering and is a frequent advisor to governmental organizations on cell-based sensing, nanobiotechnology, and tissue engineering. She holds 12 issued or pending patents and has worked in industry at Pfizer, Genetics Institute, ICI Pharmaceuticals, and Organogenesis.
Professor Mauro Ferrari is a pioneer in the fields of bioMEMS and biomedical nanotechnology. As a leading academic, a dedicated entrepreneur, and a vision setter for the Nation's premier Federal programs in nanomedicine, he brings a three-fold vantage perspective to his roles as Editor-in-Chief for this work. Dr. Ferrari has authored or co-authored over 150 scientific publications, 6 books, and over 20 US and
International patents. Dr. Ferrari is also Editor-in-Chief of Biomedical Microdevices and series editor of the new Springer series on Emerging Biomedical Technologies.
Several private sector companies originated from his laboratories at the Ohio State University and the University of California at Berkeley over the years. On a Federal assignment as Special
Expert in Nanotechnology and Eminent Scholar, he has provided the scientific leadership for the development of the Alliance for Cancer Nanotechnology of the National Cancer Institute, the world-largest medical nanotechnology operation to date. Dr. Ferrari trained in mathematical physics in Italy, obtained his Master's and Ph.D. in Mechanical
Engineering at Berkeley, attended medical school at The Ohio State University, and served in faculty positions in Materials Science and Engineering, and Civil and Environmental Engineering in Berkeley, where he was first tenured. At Ohio State he currently serves as Professor of Internal Medicine, Division of Hematology and Oncology, as Edgar Hendrickson Professor of Biomedical Engineering, and as Professor of Mechanical Engineering. He is Associate Director of the Dorothy M. Davis
Heart and Lung Research Institute, and the University's Associate Vice President for Health Science, Technology and Commercialization.
Part I Cell-based Therapeutics.- Neural regeneration.- Three dimensional hydrogel photopatterning.- Self- Assembled Peptides for tissue engineering.- Advanced bioassays for analysis of cell function.- Multicellular Biochips for Sensing.- Microelectromechanical systems and neurosurgery.- Part II Drug delivery.- Nanoporous polymer replicas for sensing drug delivery.- Nanoporous inorganic biocapsules.- Ultrasonic drug delivery.- Bioadhesive microsystems for oral drug delivery.- Targeting nanostructures.- Quantum Dot Technology.- Nanoshells for Drug Delivery.- Oncological Nanosystems.- Part III Molecular Surface Engineering for the Biological Interface.- Controlling cell-cell and cell-surface interactions.- Molecular surface engineering.- Life on a chip: Microfluidic cell culture tools for cell biology studies.- Bioresponsive surfaces.- Supported lipid bilayers as mimics for cell surfaces and as tools in biotechnology.
impairment of the quality of life itself.
Comprehensive treatment of micro and nanotechnology in drug delivery, tissue engineering, and therapeutic targeting
Chapters written by leading experts in the field
Focuses on diagnostic and therapeutic applications of MEMS and nanotechnology in biomedical engineering
Heavily illustrated with line drawings, half tones and many color illustrations