Models and Mechanisms of Cytochrome P450 Action.- Computational Approaches to Cytochrome P450 Function.- Structures of Cytochrome P450 Enzymes.- Electron Transfer Partners of Cytochrome P450.- Activation of Molecular Oxygen by Cytochrome P450.- Substrate Oxidation by Cytochrome P450 Enzymes.- Inhibition of Cytochrome P450 Enzymes.- Induction of Cytochrome P450 Enzymes.- Hormonal Regulation of Liver Cytochrome P450 Enzymes.- Human Cytochrome P450 Enzymes.- Cytochrome P450 and the Metabolism and Bioactivation of Arachidonic Acid and Eicosanoids.- Cytochrome P450s in Plants.- The Diversity and Importance of Microbial Cytochromes P450.
Cytochrome P450: Structure, Mechanism, and Biochemistry, third edition is a revision of a review that summarizes the current state of research in the field of drug metabolism. The emphasis is on structure, mechanism, biochemistry, and regulation. Coverage is interdisciplinary, ranging from bioinorganic chemistry of cytochrome P450 to its relevance in human medicine. Each chapter provides an in-depth review of a given topic, but concentrates on advances of the last 10 years.