1. Theory of Organelle Biogenesis: A Historical Perspective; Barbara M. Mullock and J. Paul Luzio.- Definitions.- The History of Organelle Recognition.- Protein Synthesis and Targeting.- Organization into Complex Structures.- Organelle Inheritance.-Challenges.- 2. Protein Coats As Mediators of Intracellular Sorting and Organelle Biogenesis; Chris Mullins.- Clathrin: A Scaffold for Protein Coats.- Adaptor Protein Complexes: Adaptors for Coats of the Late-Secretory and Endocytic Pathways.- COP Complexes: Protein Coats of the Early Secretory Pathway.- Adaptor-Related Proteins Define Novel Coats of the Secretory and Endocytic Pathways.- 3. The Role of Proteins and Lipids in Organelle Biogenesis in the Secretory Pathway; Thomas F. J. Martin.- Protein Sorting Confers a Transient Nature to Secretory Pathway Organelles.- The Molecular Machinery Regulating Compartment Identity.- General Mechanisms Employed for Cargo Exit and Entry: Fission and Fusion.- Exit Mechanisms in Trafficking.- Entry Mechanisms in Trafficking: Tethering, Priming and Fusion.- 4. Endoplasmic Reticulum Biogenesis: Proliferation and Differentiation; Erik Snapp.- ER Functions.- Building Blocks of the ER.- ER Biogenesis.- ER Network Formation.- ER Subdomains.- ER Differentiation.- Putting It All Together. Appendices.- 5. The Golgi Apparatus: Structure, Function and Cellular Dynamics; Nihal Altan-Bonnet and Jennifer Lippincott-Schwartz.- Golgi Structure and Distribution.- Golgi Function and Compartmentalization.- Transport within the Golgi Complex.- Golgi Dynamics: Interphase.- Golgi Dynamics: Mitosis.- Golgi As a Scaffold for Signaling Molecules.- 6. Lysosome Biogenesis and Dynamics; Diane McVey Ward, Shelly L. Shiflett and Jerry Kaplan.- Models for Lysosome Biogenesis.- Synthesis and Delivery of Lysosomal Hydrolases.- Synthesis and Trafficking of Lysosomal Membrane Proteins.- Lysosomes and Endosomes Undergo Fusion and Fission.- Lysosomes Are Capable of Fusion with the Plasma Membrane.- Movement of Lysosomes.- 7. Nucleogenesis; Sui Huang.- The Nuclear Envelope in Mitosis.- Post-Mitotic Biogenesis of the Nucleolus.- 8. Mitochondrial Biogenesis.- Danielle Leuenberger, Sean P. Curran and Carla M. Koehler.- Mitochondrial Dynamics.- Mitochondrial Protein Import.- Mitochondrial Protein Export.- The Protein Surveillance System of the Mitochondrion.- Metal Ion Transport.- 9. The Biogenesis and Cell Biology of Peroxisomesin Human Health and Disease; Stanley R. Terlecky and Paul A. Walton.- Biogenesis of Peroxisomal Membranes.- Early Acting Peroxins.- The "Preperoxisome": A Precursor Organelle to the Peroxisome?- Molecular Mechanisms of Peroxisomal Protein Import.- Index.
The Biogenesis of Cellular Organelles represents a comprehensive summary of recent advances in the study of the biogenesis and functional dynamics of the major organelles operating in the eukaryotic cell. This book begins by placing the study of organelle biogenesis in a historical perspective by describing past scientific strategies, theories, and findings and relating these foundations to current investigations. Reviews of protein and lipid mediators important for organelle biogenesis are then presented, and are followed by summaries focused on the endoplasmic reticulum, Golgi, lysosome, nucleus, mitochondria, and peroxisome.
All chapters in The Biogenesis of Cellular Organelles are written by experts in their fields and, though concentrated on particular topics, are integrated under the general themes of organelle structure, function, dynamics, and biogenesis. An understanding of these concepts is important for all researchers and students interested in general cell biology and particularly to those with interests in organelle function.